About Rui Song, MB, DSc
I have broad and strong background in pharmacology, physiology and cardiovascular science, with specific training and expertise in animal techniques, RT-PCR, ELISA, western blot, cell and organ isolation, histology and cell culture. My current research interest focuses on the molecular mechanism underlying the adaptive/maladaptive changes of the uteroplacental circulation during pregnancy under physiological and pathophysiological conditions. Another is to demonstrate the susceptibility and mechanism of myocardial infarction and heart failure in adult and offspring with prenatal hypoxia exposure. My works lead to several peer-reviewed publications and some of them listed below.
1. Hu XQ, Song R, Dasgupta C, Romero M, Juarez R, Hanson J, Blood AB, Wilson SM, Zhang L. MicroRNA-210-mediated mtROS confer hypoxia-induced suppression of STOCs in ovine uterine arteries. Br J Pharmacol. 2022 Oct;179(19):4640-4654. PubMed Central PMCID: PMC9474621.
2. Song R, Dasgupta C, Mulder C, Zhang L. MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction. Circulation. 2022 Apr 12;145(15):1140-1153. PubMed Central PMCID: PMC9007902.
3. Song R, Hu XQ, Romero M, Holguin MA, Kagabo W, Xiao D, Wilson SM, Zhang L. Ryanodine receptor subtypes regulate Ca2+ sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy. Cardiovasc Res. 2021 Feb 22;117(3):792-804. PubMed Central PMCID: PMC7898951.
4. Huang L, Chen X, Dasgupta C, Chen W, Song R, Wang C, Zhang L. Foetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease. Cardiovasc Res. 2019 Jul 1;115(8):1306-1319. PubMed Central PMCID: PMC6587923.