Research Projects & Grants

College/University

• Evaluation of volatile markers in patients with severe sepsis or septic shock and healthy volunteers, Role: PI, University of California, San Diego, (01/2013 - 01/2014) Status: Completed
• PROTOCOLIZED CARE FOR EARLY SEPTIC SHOCK (PROCESS), Role: Principal Investigator, University of Pittsburgh, (09/2008 - 08/2009) Status: Closed
• Protocolized Care for Early Septic Shock (Process), Role: Principal Investigator, University of Pittsburgh, (09/2007 - 08/2008) Status: Closed
• Protocolized Care for Early Septic Shock, Role: Principal Investigator, University of Pittsburgh, (09/2006 - 08/2010) Status: Closed

Federal

• Non-invasive hemodynamic characterization of patients receiving early goal-directed therapy for the management of septic shock, Role: Principal Investigator, National Medical Technology Testbed, Inc., (02/2009 - 03/2011) Status: Closed
• The effect of telemedicine on pre-hospital care of nursing home patients, Role: Investigator, Department of Defense, (04/2007 - 04/2008) Status: Completed

For Profit Organization

• Clinical Protocol – AST-132 - A Sample Collection Study to Validate the NEPHROCLEAR™ CCL14 Test, Role: PI, Astute Medical, Inc, (11/2021) Status: Completed
• LJ501-CRH01: A phase 3, placebo-controlled, randomized, double-blind, multi-center study of LJPC-501 in patients with catecholamine-resistant hypotension (CRH), Role: PI, La Jolla Pharmaceutical Company, (02/2017 - 02/2018) Status: Completed
• Evaluating the use of polymyxin B hemoperfusion in a randomized controlled trial of adults treated for endotoxemia and septic shock (EUPHRATES), Role: PI, Spectral Diagnostics Inc., (07/2014 - 07/2015) Status: Completed
• A sample collection study to validate the astute medical NephroCheck test in critically ill subjects at risk for acute kidney injury, Role: PI, Astute Medical, Inc, (06/2012 - 06/2013) Status: Completed
• Efficacy and safety of drotrecogin alfa (activated) in adult patients with septic shock, Role: Investigator, Eli Lilly & Co., (09/2011 - 09/2012) Status: Completed
• Clinical utility of biomarkers in the assessment of sepsis, Role: PI, Biosite, Inc., (12/2009 - 12/2010) Status: Completed
• A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin alfa in patients with severe sepsis, protocol LF-0801, Role: Investigator, Agennix, Inc., (03/2009 - 03/2010) Status: Completed
• The educational value of a simulation curriculum on participant knowledge in hemodynamic monitoring concepts, Role: PI, Edwards Lifesciences, (02/2007) Status: Completed
• Comparison of venous oxygen saturation from pulse oximetry waveform analysis and central venous catheter, Role: PI, Edwards Lifesciences, (05/2006 - 05/2007) Status: Completed
• A point of care study investigating the variability of FENO measurements with NIOXMINO performed by different operators, Role: Investigator, Aerocrine, Inc., (03/2005 - 03/2006) Status: Completed
• (CDA) Coronavirus Disease (COVID-19) Study, Role: PD/PI, Amarex Clinical Research, LLC, Status: Awarded
• (CDA) A Randomized, Double-Blinded, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of TJ003234 in Subjects with Severe Coronavirus Disease 2019 (COVID-19), Role: PD/PI, I-MAB Biopharma US Limited, Status: Awarded

Internal

• Comparative Analysis of Answers to Patient Care Questions: An AI Chatbot (ChatGPT) vs. Physician, Role: PI, LLU Dept. of Medicine, (06/2024) Status: Approved
• Convalescent Plasma to Treat Coronavirus - Associated Severe Pulmonary Complications: A Correlation Study of Serologic Anti-SARS-CoV-2 antibody to Treatment Efficacy and Outcome, Role: Investigator, LLU Basic Science, (06/2020) Status: Approved
• Comparing Clinical Outcomes between SARS-CoV-2 PCR Positive and Negative Hospitalized Patients with Lower Respiratory Tract Infection (LRTIS), Role: Investigator, LLU Dept. of Medicine, (04/2020) Status: Approved
• The effectiveness of the vasopressor Angiotensin-II in septic shock or vasodilatory shock patients, Role: PI, LLU Dept. of Medicine, (04/2020 - 03/2021) Status: Completed
• STOP-COVID: Study of the treatment and outcomes in critically ill patients, Role: PI, LLU Dept. of Medicine, (03/2020) Status: Completed
• Precision of determining fluid responsiveness by the passive leg raise maneuver in critically ill patients using Non-invasive Cardiac Output Monitor (NiCOM)™, Role: PI, LLU Dept. of Medicine, (05/2019 - 05/2020) Status: Completed
• A multi-center evaluation of the NEMO gauge to aid in correct positioning of the endotracheal tube after intubation of critically ill patients, Role: Investigator, LLU Dept. of Medicine, (04/2017 - 04/2018) Status: Completed
• Central management of the study, "A multi-center evaluation of the NEMO gauge to aid in correct positioning of the endotracheal tube after intubation of critically ill patients" - IRB #5160137, Role: PI, LLU Dept. of Medicine, (04/2017 - 04/2018) Status: Completed
• A randomized study of Ultrasound Simulation Training by residents Immediately Prior to Central venous catheter Insertion and its effects on catheter insertion success and catheter-related outcomes (US-TIPCI), Role: Investigator, LLU School of Medicine, (07/2016 - 07/2017) Status: Completed
• Septic Shock and Early Goal Directed Therapy in Patients with End Stage Renal Disease, Role: Investigator, LLU Dept. of Medicine, (12/2015) Status: Completed
• Second vasopressor choice and its associated outcomes for patients presenting with hypotension due to severe sepsis or septic shock, Role: PI, LLU Dept. of Pharmaceutical Sciences, (01/2015 - 01/2016) Status: Completed
• Registry for patients with sepsis presenting to the Emergency Department, Role: PI, LLU Dept. of Emergency Medicine, (11/2014 - 11/2015) Status: Completed
• Evaluation of vitamin D status in patients with sepsis, Role: PI, LLU Dept. of Medicine, (06/2014 - 06/2015) Status: Completed
• Registry of Percutaneous Dilatational Tracheotomy (PDT) performed by intensivists, Role: PI, LLU Dept. of Medicine, (05/2014 - 05/2015) Status: Completed
• Comparative effectiveness of guideline definitions and clinician judgment in identifying sepsis, Role: PI, LLU Dept. of Medicine, (09/2013 - 09/2014) Status: Completed
• IMPact of a Critical care ultrasound course during fellowship Training (IMPACT), Role: Investigator, LLU Dept. of Medicine, (08/2013 - 07/2014) Status: Completed
• Retrospective validation of vascular pedicle width (VPW) as a diagnostic aid in critically ill patients with pulmonary edema, Role: PI, LLU Dept. of Medicine, (05/2013 - 05/2014) Status: Completed
• Registry for adult patients with return of spontaneous circulation after cardiac arrest, Role: PI, LLU Dept. of Emergency Medicine, (12/2011 - 12/2012) Status: Completed
• Cardiac index using standard trans-thoracic echocardiography (CaUSE) in the emergency department, Role: PI, LLU Dept. of Emergency Medicine, (10/2011 - 10/2012) Status: Completed
• Obtaining human blood for the purpose of isolating monocytes for adoptive gene therapy in animal model of inflammatory bowel disease, Role: PI, LLU Dept. of Medicine, (09/2011 - 09/2012) Status: Completed
• Static and dynamic measurements of fluid responsiveness in the medical intensive care patients, Role: PI, LLU Dept. of Medicine, (02/2010 - 02/2011) Status: Completed
• Epidemiologic characteristics of Emergency department deaths, Role: Investigator, LLU Dept. of Emergency Medicine, (07/2009) Status: Completed
• Non-Invasive Cardiovascular hermodynamic endpoint for early seven sepsis and septic shock (NiCHES), Role: Principal Investigator, LLU School of Medicine (BRSG), (02/2009 - 03/2011) Status: Closed
• Observational study of non-invasive doppler ultrasound hemodynamic monitoring in the shock patient in the emergency department, Role: PI, LLU Dept. of Emergency Medicine, (01/2007 - 01/2008) Status: Completed
• Transition from research to standard care in the management of severe sepsis: a survey of early adopters, Role: PI, LLU Dept. of Emergency Medicine, (11/2006 - 11/2007) Status: Completed
• EFFICACY AND SAFETY OF OCTAGAM 10% THERAPY IN COVID-19 PATIENTS WITH SEVERE DISEASE PROGRESSION, Role: PI, LLU Dept. of Medicine, Status: Completed
• A Double-Blind, Placebo-ControIled Phase 2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of OP-l 01 (dendrimer n-acetyl-cysteine) in Patients with Severe COVID-19, Role: PI, LLU Dept. of Medicine, Status: Completed

Non-Profit Organization

• Lowering Barriers to Access HIV Care in a Geographically and Economically Diverse Area - Tier II, Role: Consultant, Colorado Foundation for Public Health and the Environment, (04/2015 - 06/2017) Status: Closed
• Life after Sepsis: An international survey of survivors to understand the post-sepsis syndrome, Role: PI, Patient-Centered Outcomes Research Institute (PCORI), (08/2014) Status: Completed
• Preventing Missed Appointments for for HIV Patients, Role: Principal Investigator, Colorado Foundation for Public Health and the Environment, (03/2014 - 11/2014) Status: Closed
• Sepsis Survival Engagement Project (SSEP), Role: Principal Investigator, Colorado Foundation for Public Health and the Environment, (03/2014 - 03/2016) Status: Closed
• Cardiac Index Using Standard Trans-thoracic Echocardiography (CaUSE) in the Emergency Department, Role: Other Professional, Emergency Medicine Foundation, (03/2011 - 02/2012) Status: Closed
• (DTA) Clinical Features of COVID-19 Disease in Critically Ill Patients in the US: A Multicenter Study, Role: PD/PI, Brigham & Women's Hospital, Status: Closed