Publications

Scholarly Journals--Published

• Reid C, Romero M, Glasgow S, Dobyns A, Chang S, Osman N, Puglisi J, Wilson CG, Blood AB, Hessinger DA, Zhang L, Wilson SM. Long term hypoxia negatively influences Ca2+ signaling in basilar arterial myocytes of fetal and adult sheep. Front Physiol, 2022 Jan 18;12:760176. doi: 10.3389/fphys.2021.760176. eCollection 2021. PMCID: PMC8804533 (2022)
• Song R, Dasgupta C, Mulder C, Zhang L. MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction. Circulation 145: 1140-1153, 2022. PMCID: PMC9007902 (2022)
• Hu X, Zhang L. Mitochondrial dysfunction in the pathogenesis of preeclampsia. Current Hypertension Report 2022 Mar 7. doi: 10.1007/s11906-022-01184-7 (2022)
• Li Y, Zhang Y, Walayat A, Fu Y, Liu B, Zhang L, Xiao D. The regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype. Int J Mol Sci 2022 Jun 21;23(13):6885. doi: 10.3390/ijms23136885 (2022)
• Hu X, Song R, Dasgupta C, Romero M, Juarez R, Hanson J, Blood AB, Wilson SM, Zhang L. MicroRNA-210-mediated mitochondrial reactive oxygen species confers hypoxia-induced suppression of spontaneous transient outward currents in ovine uterine arteries. Brit J Pharmacol 179: 4640-4654, 2022 (2022)
• Song R, Zhang L. Response by Song and Zhang to Letters Regarding Article, "MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction.” Circulation 146: e171-e172, 2022. (2022)
• Liu T, Zhang M, Mourkus A, Schroeder H, Zhang L, Power GG, Blood AB. Chronic high-altitude hypoxia alters iron and nitric oxide homeostasis in fetal and maternal sheep blood and aorta. Antioxidants 2022 Sep 15;11(9):1821. doi: 10.3390/antiox11091821 (2022)
• Walayat A, Li Y, Zhang Y, Fu Y, Liu B, Shao XM, Zhang L, Xiao D. Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 321: R791-R801, 2021. doi: 10.1152/ajpregu.00207.2021. PMCID: PMC8616627 (2021)
• Song R, Hu XQ, Romero M, Holguin MA, Kagabo W, Xiao D, Wilson SM, Zhang L. Ryanodine receptor subtypes regulate Ca2+ sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy. Cardiovasc Res 117: 792-804, 2021. PMCID: PMC7898951 (2021)
• Ma Q, Dasgupta C, Li Y, Zhang L. MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury. J Neuroinflammation, 2021 Jan 5;18(1):6. doi: 10.1186/s12974-020-02068-w. PMCID: PMC7786974 (2021)
• Hu X, Dasgupta C, Song R, Romero M, Wilson SM, Zhang L. MicroRNA-210 mediates hypoxia-induced repression of spontaneous transient outward currents in uterine arteries during gestation. Hypertension 77:1412-1427, 2021. PMCID: PMC7946727 (2021)
• Leslie E, Lopez V, Anti N, Alvarez R, Kafeero I, Welsh DG, Romero M, Kaushal S, Brito A, La Frano MR, Johnson C, Bosviel R, Blazenovic I, Song R, Zhang L, Newman J, Feihn O, Wilson SM. Gestational long-term hypoxia induces metabolomic reprogramming and phenotypic transformations in fetal sheep pulmonary arteries. Am J Physiol Lung Cellular and Molecular Physiology, 320: L770-L784, 2021. PMCID: PMC8174832 (2021)
• Hu X, Zhang L. Hypoxia and reprogramming of mitochondrial metabolism and oxidative stress in vascular dysfunction. Antioxidants 2021 Mar 8;10(3):405. doi: 10.3390/antiox10030405. PMCID: PMC7999178 (2021)
• Hu X, Zhang L. Hypoxia and integrated stress response promote pulmonary hypertension and preeclampsia: implications in drug development. Drug Discovery Today 26:2754-2773, 2021. PMC8612951 (2021)
• Shen G, Hu S, Zhao Z, Zhang L, Ma Q. C-type natriuretic peptide ameliorates vascular injury and improves neurological outcome in neonatal hypoxic-ischemic brain injury in mice. Int J Mol Sci 2021 Aug 20;22(16):8966.  doi: 10.3390/ijms22168966. PMCID: PMC8396645 (2021)
• Tong Y, Zhang S, Riddle S, Zhang L, Song R, Yue D,. Intrauterine hypoxia and epigenetic programming in lung development and disease. Biomedicines 2021 Aug 2;9(8):944. doi: 10.3390/biomedicines9080944. PMCID: PMC8394854 (2021)
• Hu X, Zhang L. Uteroplacental circulation in normal pregnancy and preeclampsia: functional adaptation and maladaptation. Int J Mol Sci 2021 Aug 11;22(16):8622. doi: 10.3390/ijms22168622. PMCID: PMC8395300 (2021)
• Zhang Y, Yang M, Li Y, Liu B, Zhang L, Xiao D. Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life. Reproductive Toxicology 105:198-210, 2021. doi: 10.1016/j.reprotox.2021.09.007. PMCID: PMC8511209 (2021)
• Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB, Provencher S, Zhang L, Uchida S. Clinical values of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases. Am J Physiol Cell Physiol 318: C1-C28, 2020. PMCID: PMC6986837 (2020)
• Meng X, Zhang P, Zhang L. Fetal Hypoxia Impacts on Proliferation and Differentiation of Sca-1+ Cardiac Progenitor Cells and Maturation of Cardiomyocytes: A Role of MicroRNA-210. Genes (Basel). 2020 Mar 20;11(3):328. doi: 10.3390/genes11030328. PMCID: PMC7140790 (2020)
• Feng X, Li X, Yang C, Ren Q, Li N, Zhang L, Zhou X, Xu Z. Maternal high-sucrose diet accelerated vascular stiffness in aged offspring via suppressing Cav1.2 and contractile phenotype of VSMCs. Molecular Nutrition & Food Research, 2019 May 8:e1900022. doi: 10.1002/mnfr.201900022. [Epub ahead of print]. PMID: 31067604 (2020)
• Li B, Dasgupta C, Huang L, Meng X, Zhang L. MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy. Cell Mol Immunol 17: 976-991, 2020. PMCID: PMC7608107 (2020)
• Zhang P, Li Y, Fu Y, Huang L, Liu B, Qin S, Zhang, D, Zhang L, Shao XM, Xiao D. Inhibition of autophagy signaling via 3-methyladenine rescued nicotine-mediated cardiac pathological effects and heart dysfunctions. Int J Biol Sci 16: 1349-1362, 2020.  PMCID: PMC7085229 (2020)
• Hu XQ, Song R, Romero M, Dasgupta C, Hatcher D, Xiao D, Blood AB, Wilson SM, Zhang L. Gestational hypoxia inhibits pregnancy-induced upregulation of Ca2+ sparks and spontaneous transient outward currents in uterine arteries via heightened endoplasmic reticulum/oxidative stress. Hypertension 76: 930-942, 2020. PMCID: PMC7429261 (2020)
• Shen G, Hu S, Zhao Z, Zhang L, Ma Q. Antenatal hypoxia accelerates the onset of Alzheimer's disease pathology in 5xFAD mouse model. Front Aging Neurosci 2020 Aug 21;12:251. doi: 10.3389/fnagi.2020.00251. eCollection. PMCID: PMC7472639 (2020)
• Jian J, Zhang P, Li Y, Liu B, Zhang Y, Zhang L, Shao XM, Zhuang J, Xiao D. Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype late in life. Theranostics 10: 11820-11836, 2020. PMCID: PMC7546014 (2020)
• Patterson AJ, Choe D, Song MA, Xiao D, Foster G, Zhang L. Early detection of coronary artery disease by micro-RNA analysis in asymptomatic patients stratified by coronary CT angiography. Diagnostics 2020 Oct 28;10(11):E875. doi: 10.3390/ diagnostics10110875. PMCID: PMC7693112 (2020)
• Song R, Zhang L. Cardiac ECM: its epigenetic regulation and role in heart development and repair. Int J Mol Sci 2020 Nov 15;21(22):8610. doi: 10.3390/ijms21228610.  PMCID: PMC7698074 (2020)
• Li B, Meng X, Zhang L. MicroRNAs and Cardiac Stem Cells in Heart Development and Disease. Drug Discovery Today 24: 233-240, 2019.  PMCID: PMC6261710 (2019)
• Huang L, Zhang L. Neural stem cell therapies and hypoxic-ischemic brain injury. Progress in Neurobiology 173: 1-17, 2019 PMCID: PMC6249121 (2019)
• Zhang P, Ke J, Li Y, Huang L, Chen Z, Huang X, Zhang L, Xiao D. Long-term exposure to high altitude hypoxia during pregnancy increases fetal heart susceptibility to ischemia/reperfusion injury and cardiac dysfunction. International J of Cardiology 274: 7-15, 2019.  with an Editorial Comment PMCID: PMC6242757 (2019)
• Huang L, Chen X, Dasgupta C, Chen W, Song R, Wang C, Zhang L. Fetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease. Cardiovas Res 115: 1306-1319, 2019. PMCID: PMC6587923 (2019)
• Hu XQ, Song R, Romero M, Dasgupta C, Huang X, Holguin MA, Williams V, Xiao D, Wilson SM, Zhang L. Pregnancy increases Ca2+ sparks/STOCs and reduces uterine arterial myogenic tone. Hypertension 73: 691-702, 2019. PMCID: PMC6374197 (2019)
• Hu XQ, Song R, Zhang L. Effect of oxidative stress on estrogen-NOS-KCa pathway in uteroplacental dysfunction: its implication in pregnancy complications. Oxidative Medicine and Cellular Longevity 2019 Feb 10;2019: 9194269. doi: 10.1155/2019/9194269. eCollection 2019. PMCID: PMC6387699 (2019)
• Ma Q, Dasgupta C, Li Y, Huang L, Zhang L. MicroRNA-210 downregulates ISCU and induces mitochondrial dysfunction and neuronal death in neonatal hypoxic-ischemic brain injury. Mol Neurobiol 56: 5608-5625, 2019. PMCID: PMC6873808 (2019)
• Liu B, Hu X, Li Y, Ke J, Dasgupta C, Chen Z, Huang X, Zhang P, Walayat A, Zhang L, Xiao D. Epigenetic down-regulation of BKCa channel by miR-181a contributes to the perinatal nicotine-mediated exaggerated coronary vascular tone in adult life. International Journal of Cardiology 281: 82-89, 2019. PMCID: PMC6392075 (2019)
• Song R, Hu XQ, Zhang L. Glucocorticoids and programming of microenvironment in the heart development and function. Journal of Endocrinology, 242: T121-TT133, 2019. PMCID: PMC6602534 (2019)
• Lv J, Ma Q, Dasgupta C, Xu Z, Zhang L. Antenatal hypoxia and programming of glucocorticoid receptor expression in the adult rat heart. Front Physiol 02 April 2019 | https://doi.org/10.3389/fphys.2019.00323 (IF: 4.134) PMCID: PMC6454194 (2019)
• Ma Q, Zhang L, Pearce WJ. MicroRNAs in brain development and cerebrovascular pathophysiology. Am J Physiol Cell Physiol 317: C3-C19, 2019. PMCID: PMC6689752 (2019)
• Chen Z, Gong L, Zhang P, Li Y, Liu B, Zhang L, Zhuang J, Xiao D. Epigenetic down-regulation of Sirt 1 via DNA methylation and oxidative stress signing contributes to the gestational diabetes mellitus-induced fetal programming of heart ischemia-sensitive phenotype in late life. International Journal of Biological Sciences, 15: 1240-1251, 2019. PMCID: PMC6567811 (2019)
• Knox-Concepcion K, Figueroa J, Hartman R, Li Y, Zhang L. Repression of the glucocorticoid receptor increases hypoxic-ischemic brain injury in a sex-dependent manner in male neonatal rats. Int J Mol Sci 2019 Jul 16;20(14). pii: E3493. doi: 10.3390/ijms20143493. PMCID: PMC6678481 (2019)
• Li Y, Song AM, Fu Y, Walayat A, Yang M, Jian J, Liu B, Xia L, Zhang L, Xiao D. Perinatal nicotine exposure alters AKT/GSK-3β/mTOR/autophagy signaling leading to development of hypoxic-ischemia sensitive phenotype in rat neonatal brain. Am J Physiol Regul Integr Comp Physiol 317: R803-R813, 2019. PMCID: PMC6962626 (2019)
• Chen X, Zhang L, Wang C. Antenatal hypoxia-induced epigenomic reprogramming and alteration of gene transcription in the rat fetal and adult offspring heart. Sci Data 2019 Oct 29;6(1):238. doi: 10.1038/s41597-019-0253-9. PMCID: PMC6820751 (2019)
• Hu XQ, Zhang L. MicroRNAs in uteroplacental vascular dysfunction. Cells 2019 Oct 29;8(11). pii: E1344. doi: 10.3390/cells8111344. PMCID: PMC6912833 (2019)
• Rood K, Lopez V, La Frano MR, Fiehn O, Zhang L, Blood AB, Wilson SM. Gestational hypoxia and programing of lung metabolism. Front Physiol 2019, 10.3389/fphys.2019.01453. PMCID: PMC6895135 (2019)
• Moretta D, Papamatheakis DG, Morris DP, Giri PC, Blood Q, Murray S, Ramzy M, Romero M, Vemulakonda S, Lauw S, Longo LD, Zhang L, Wilson SM. Long-term high-altitude hypoxia and alpha adrenoceptor-dependent pulmonary arterial contractions in fetal and adult sheep. Front Physiol 2019 Aug 28;10:1032. doi: 10.3389/fphys.2019.01032. eCollection 2019. PMCID: PMC6723549 (2019)
• Song R, Hu XQ, Zhang L. Mitochondrial miRNA in cardiovascular function and disease. Cells 2019 Nov 21;8(12). pii: E1475. doi: 10.3390/cells8121475. PMCID: PMC6952824 (2019)
• Gao Y, Dasgupta C, Huang L, Song R, Zhang Z, Zhang L. Multi-omics integration reveals short and long-term effects of gestational hypoxia on the heart. Cells 2019 Dec 11;8(12). pii: E1608. doi: 10.3390/cells8121608. PMCID: PMC6952773 (2019)
• Huang L, Ma Q, Li Y, Li B, Zhang L. Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice. Exp Neurol 300: 41-50, 2018. PMCID: PMC6089227 (2018)
• Shin AP, Han L, Dasgupta C, Huang L, Yang S, Zhang L. SIRT1 increases cardiomyocyte binucleation in the heart development. Oncotarget 9(8): 7996-8010, 2018. PMCID: PMC5814276 (2018)
• Shen CP, Romero M, Brunelle A, Wolfe C, Blood Q, Dobyns A, Francis M, Taylor MS, Puglisi JL, Longo LD, Zhang L, Wilson CG, Wilson SM. Long-Term High Altitude Hypoxia influences Pulmonary Arterial L-type Calcium Channel mediated Ca2+ signals and Contraction in Fetal and Adult Sheep. Am J Physiol Regul Integr Comp Physiol. 314: R433-R446, 2018. PMCID: PMC5899247 (2018)
• Ducsay C, Goyal R, Pearce WJ, Wilson S, Hu X, Zhang L. Gestational hypoxia and developmental plasticity. Physiological Reviews 98: 1241-1334, 2018. PMCID: 6088145 (2018)
• Ma Q, Zhang L. C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2. Exp Neurol 304: 58-66, 2018. PMCID: PMC6089427 (2018)
• Mata-Greenwood E, Blood A, Sands L, Bragg S, Xiao D, Zhang L. A novel rodent model of pregnancy complications associated with genetically determined angiotensin converting enzyme (ACE) activity. American Journal of Physiology-Endocrinology and Metabolism 315: E52-E62, 2018. PMCID: PMC6087725 (2018)
• Blum-Johnston C, Thorpe RB, Wee C, Romero M, Brunelle A, Blood Q, Wilson R, Blood AB, Francis M, Taylor MS, Zhang L, Longo LD, Pearce WJ, Wilson SM. Long term hypoxia uncouples Ca2+ and eNOS in bradykinin-mediated pulmonary arterial relaxation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314: R870-R882, 2018. PMCID: PMC6032299 (2018)
• Zhang Y, Zhang M, Li L, Wei B, He A, Lu L, Li X, Zhang L, Xu Z, Sun M. Methylation-reprogrammed Wnt/β-catenin signaling mediated prenatal hypoxia-induced brain injury in fetal and offspring rats. J Cell Mol Med 22: 3866-3874, 2018. PMCID: PMC6050486 (2018)
• Hu XQ, Dasgupta C, Xiao J, Yang S, Zhang L. Gestational hypoxia suppresses large conductance Ca2+-activated K+ channel function in uterine arteries: A causal role of microRNA-210. J Physiol 596.23 pp 5891-5906, 2018, with an Editorial Comment from Dino. PMCID: PMC6265561 (2018)
• Li Y, Hung L, Ma Q, Concepcion KR, Song MA, Zhang P, Fu Y, Xiao D, Zhang L. Repression of glucocorticoid receptor aggravates acute ischemic brain injury in adult mice. International Journal of Molecular Sciences 2018, 19, 2428; doi:10.3390/ijms19082428. PMCID: PMC6121696 (2018)
• Li Y, Zhang W, Shi R, Sun M, Zhang L, Li N, Xu Z. Prenatal caffeine damaged leaning and memory in rat offspring mediated by ARs/PKA/CREB/BDND pathway. Physiol Res 67: 975-983, 2018. PMID: 30204465 (2018)
• Concepcion KR, Zhang L. Corticosteroids and Perinatal Hypoxic-Ischemic Brain Injury. Drug Discovery Today 23: 1718-1732, 2018. PMCID: PMC6440944 (2018)
• Li Y, Ma Q, Halavi S, Hartman RE, Xiao D, Zhang L. Inhibition of DNA methylation in the developing rat brain disrupts sexually dimorphic neurobehavioral phenotypes in adulthood. Mol Neurobiol 54: 3988-3999, 2017. PMCID: PMC5161729 (2017)
• Wang L, Ke J, Li Y, Ma Q, Dasgupta C, Huang X, Zhang L, Xiao D. Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats. Int J Biol Sci 13: 76-84, 2017. PMCID: PMC5264263 (2017)
• Harding B, Conception K, Li Y, Zhang L. Glucocorticoids protect neonatal rat brain in model of hypoxic-ischemic encephalopathy (HIE). Int J Mol Sci 2017, 18(1), 17; doi:10.3390/ijms18010017 PMCID: PMC5297652 (2017)
• Tenayuca J, Cousins K, Yang S, Zhang L. Computational modeling approach in probing effects of cytosine methylation on the transcription factor binding to DNA. Curr Top Med Chem 17: 1778-1787, 2017. PMCID: PMC5639940 (2017)
• Shin AN, Dasgupta C, Zhang G, Seal K, Zhang L. Proteomic analysis of endothelin-1 targets in the regulation of cardiomyocyte proliferation. Curr Top Med Chem 17: 1788-1802, 2017. PMCID: PMC5649443 (2017)
• Zhang L. Medicinal chemistry of molecular and epigenetic targets and drug development. Curr Top Med Chem 17: 1669, 2017. (2017)
• Hu X, Chen M, Dasgupta C, Xiao D, Huang X, Yang S, Zhang L. Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K+ channel function in uterine arteries. Biol Reprod 96: 424-434, 2017. PMCID: PMC6366546 (2017)
• Gao Q, Tang J, Li N, Zhou X, Li Y, Liu Y, Wu J, Yang Y, Shi R, He A, Li X, Zhang Y, Chen J, Zhang L, Sun M, Xu Z. A novel mechanism of angiotensin II-regulated placental vascular tone in the development of hypertension in preeclampsia. Oncotarget 8: 30734-30741, 2017. PMCID: PMC5458163 (2017)
• Hu XQ, Dasgupta C, Chen M, Xiao D, Huang X, Han L, Yang S, Xu Z, Zhang L. Pregnancy reprograms large-conductance Ca2+-activated K+ channel in uterine arteries: roles of Ten-Eleven Translocation Methylcytosine Dioxygenase 1-mediated active demethylation. Hypertension 69: 1181-1191, 2017. PMCID: PMC5426984 (2017)
• Martinez SR, Ma Q, Dasgupta C, Zhang L. miR-210 suppresses glucocorticoid receptor expression in response to hypoxia in fetal rat cardiomyocytes. Oncotarget 8(46): 80249-80264 2017. PMCID: PMC5655194 (2017)
• Hu X, Zhang L. Angiogenesis during pregnancy: All routes lead to MAPKs. J Physiol 595: 4571-4572, 2017. PMCID: PMC5509881 (2017)
• He A, Zhang Y, Li L, Feng X, Wei B, Zhu D, Liu Y, Wu L, Zhang L, Xu Z, Sun M. Long-term influence of prenatal high sucrose intake on learning and memory of aged rat offspring with oxidative stress and disruptions in NMDARs/Wnt signaling in hippocampus. Brain Res 1169: 114-121, 2017. PMCID: PMC5639946 (2017)
• Ma Q, Zhang L. MicroRNA 210 and mitochondrial pathway in neonatal hypoxic-ischemic encephalopathy. Oncotarget 8: 38078-38079, 2017. PMCID: PMC5503514 (2017)
• Ma Q, Dasgupta C, Li Y, Huang L, Zhang L. MicroRNA-210 suppresses junction proteins and disrupts blood-brain barrier integrity in neonatal rat hypoxic-ischemic brain injury. International Journal of Molecular Sciences 2017 Jun 24;18(7). pii: E1356. doi: 10.3390/ijms18071356. PMCID: PMC5535849 (2017)
• Hu XQ, Dasgupta C, Xiao D, Huang X, Yang S, Zhang L. Micro RNA-210 targets TET1 and suppresses pregnancy-mediated adaptation of BKCa channel expression and function in ovine uterine arteries. Hypertension 70: 601-612, 2017. PMCID: PMC5783798 (2017)
• Shamloo K, Chen J, Sardar J, Sherpa RT, Pala R, Atkinson KF, Pearce WJ, Zhang L, Nauli SM. Chronic hypobaric hypoxia modulates primary cilia differently in adult and fetal ovine kidneys. Frontiers in Physiology September 2017 Volume 8: Article 677, doi: 10.3389/fphys.2017.00677. PMCID: PMC5611369 (2017)
• Ke J, Dong N, Wang L, Li Y, Dasgupta C, Zhang L, Xiao D. Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring. Oncotarget 8: 76865-76880, 2017 PMCID: PMC5652749 (2017)
• Zhang P, Lv J, Li Y, Zhang L, Xiao D. Neonatal lipopolysaccharide exposure gender-dependently increases heart susceptibility to ischemia/reperfusion injury in male rats. International Journal of Medical Sciences 14: 1163-1172, 2017. PMCID: PMC5666548 (2017)
• Li B, Concepcion K, Meng X, Zhang L. Brain-immune interactions in perinatal hypoxic-ischemic brain injury. Progress in Neurobiology 159: 50-68, 2017. PMCID: PMC5831511 (2017)
• Li Y, Ma Q, Halavi S, Hartman RE, Obenaus A, Xiao D, Zhang L. Inhibition of DNA methylation in the developing brain increases brain susceptibility to hypoxic-ischemic injury in neonatal rats. Exp Neurol 275: 1-10, 2016.  PMCID: PMC4785034 (2016)
• Hu X, Huang X, Xiao D, Zhang L. Direct effect of chronic hypoxia in suppressing large conductance Ca2+-activated K+ channel activity in ovine uterine arteries via increasing oxidative stress. J Physiol 594.2: 343–356, 2016. PMCID: PMC4713733 (2016)
• Ma Q, Dasgupta C, Li Y, Mistry N, Xiong F, Hartman R, Zhang L. Inhibition of miRNA-210 provides neuroprotection and improves long-term neurological function recovery in hypoxic-ischemic brain injury in neonatal rats. Neurobiol Dis 89: 202-212, 2016. PMCID: PMC4785034 (2016)
• Xiong F, Lin T, Song M, Ma Q, Martinez S, Lv J, Matagreenwood E, Xiao D, Xu Z, Zhang L. Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart. J Mol Cell Cardiol 91: 160-171, 2016. PMCID: PMC4764467 (2016)
• Zhu Z, Tang J, Zhou X, Xiang S, Zhu X, Li N, Shi R, Zhong Y, Zhang L, Sun M, Xu Z. Roles of ion channels in regulation of acetylcholine-mediated vasoconstrictions in umbilical cords of rabbit/rats. Reprod Toxicol 65: 95-103, 2016. PMCID: PMC5638043 (2016)
• Xiao D, Wang L, Huang XH, Li Y, Dasgupta C, Zhang L. Protective effect of antenatal antioxidant on nicotine-induced heart ischemia-sensitive phenotype in rat offspring. PLoS One 11: e0150557, 2016. PMCID: PMC4769226 (2016)
• Gao Q, Zhu X, Chen J, Mao C, Zhang L, Xu Z. Upregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia. J Hypertens 34: 1380-1388, 2016. PMCID: PMC5649442 (2016)
• Gay MS, Dasgupta C, Li Y, Zhang L. Epigenetic repression of cyclin D2 mediates dexamethasone-induced cardiomyocyte terminal differentiation. J Pharmacol Exp Ther 358: 190-198, 2016. PMCID: PMC4959091 (2016)
• Ma Q, Zhang L. Nutritional stress and fetal epigenetics in the brain. The Handbook of Nutrition, Diet and Epigenetics submitted 10/10/16. (2016)
• Xia S, Lv J, Gao Q, Li L, Chen N, Wei X, Xiao J, Chen J, Tao J, Sun M, Mao C, Zhang L, Xu Z. Prenatal exposure to hypoxia induced Beclin 1 signaling-mediated renal autophagy and altered renal development in rat fetuses. Reprod Sci 22: 156-164, 2015.   PMCID: PMC4287595 (2015)
• Ma Q, Zhang L. Epigenetic Programming of Hypoxic-Ischemic Encephalopathy in Response to Fetal Hypoxia. Progress in Neurobiology 124: 28-48, 2015. PMCID: PMC4272655 (2015)
• Song M, Paradis AN, Gay MS, Shin J, Zhang L. Differential expression of microRNAs in ischemic heart disease. Drug Discovery Today 20: 223-235, 2015.   PMCID: PMC4336590 (2015)
• Shi L, Zhang H, Chen Y, Liu Y, Lu N, Zhao T, Zhang L. Chronic exercise normalizes changes of Cav 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats. Br J Pharmacol 172: 1846-1858, 2015. PMCID: PMC4376461 (2015)
• Martinez SR, Gay MS, Zhang L. Epigenetic mechanisms in the heart development and disease. Drug Discovery Today 20: 799-811, 2015. PMID: 25572405 (2015)
• Paradis AN, Gay M, Wilson CG, Zhang L. Newborn hypoxia/anoxia decreases cardiomyocyte proliferation and endowment in the developing heart: role of endothelin-1. PLoS One 10: e0116600, 2015.   PMCID: PMC4414482 (2015)
• Gay MS, Li Y, Xiong F, Lin T, Zhang L. Dexamethasone treatment of newborn rats decreases cardiomyocyte endowment in the developing heart through epigenetic modifications. PLoS One 10:e0125033, 2015.  PMCID: PMC4414482 (2015)
• Chen M, Xiao D, Hu XQ, Dasgupta C, Yang S, Zhang L. Hypoxia represses ERα expression and inhibits estrogen-induced regulation of BKca channel activity and myogenic tone in ovine uterine arteries: the causal role of DNA methylation. Hypertension 66: 44-51, 2015.  PMCID: PMC4465851 (2015)
• Shi L, Liao J, Liu B, Zeng F, Zhang L. Mechanisms and therapeutic potential of microRNAs in hypertension. Drug Discovery Today 20: 1188-1204, 2015. PMCID: PMC4609581 (2015)
• Xue Q, Patterson AJ, Xiao D, Zhang L. Estrogen regulates angiotensin II receptor expression patterns and protects the heart from ischemic injury in female rats. Biol Reprod 93(1):6, 1-9, 2015. PMCID: PMC4706310 (2015)
• Song M, Dasgupta C, Zhang L. Chronic losartan treatment up-regulates AT1R and increases the heart vulnerability to acute onset of ischemia and reperfusion injury in male rats. PLoS One 10(7):e0132712, 2015. PMCID: PMC4500443 (2015)
• Mata-Greenwood E, Jackson PN, Pearce WJ, Zhang L. Endothelial GR transcriptional regulation according to dexamethasone sensitivity. J Mol Endocrinol 55: 133-146, 2015. PMCID: PMC5113289 (2015)
• Xiao D, Huang X, Li Y, Dasgupta C, Wang L, Zhang L. Antenatal antioxidant prevents nicotine-mediated hypertensive response in rat adult offspring. Biol Reprod 93(3):66, 1-8, 2015. PMCID: PMC4710188 (2015)
• González P, Xiong F, Li Y, Zhang L. Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of glucocorticoid receptors. Neurobiol Dis 65: 172-179, 2014.   PMCID: PMC3990589 (2014)
• Paradis AN, Gay MS, Zhang L. Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state. Drug Discovery Today, 19: 602-609, 2014. PMCID: PMC4007385 (2014)
• Xiao D, Dasgupta C, Chen M, Zhang K, Buchholz J, Xu Z, Zhang L. Inhibition of DNA Methylation Reverses Norepinephrine-Induced Cardiac Hypertrophy in Rats. Cardiovasc Res 101: 373-382, 2014. PMCID: PMC3927999 (2014)
• Goyal R, Zhang L, Blood A, Baylink DJ, Longo LD, Oshiro B, Mata-Greenwood E. Characterization of an animal model of pregnancy-1 induced vitamin D deficiency due to metabolic gene dysregulation. Am J Physiol Endo 306: E256-E266, 2014. PMID: 24326417 (2014)
• Paradis AN, Xiao D, Zhou J, Zhang L. Endothelin-1 promotes cardiomyocyte terminal differentiation in the developing heart via heightened DNA methylation. Int J Med Sci 11: 373-380, 2014. PMCID: PMC3936032 (2014)
• Xiao D, Huang X, Xue Q, Zhang L. Antenatal hypoxia induces programming of reduced arterial blood pressure response in female rat offspring: role of ovarian function. PLoS One 9: e98743, 2014. PMCID: PMC4048263 (2014)
• Zhu R, Huang X, Hu X, Xiao D, Zhang L. Gestational hypoxia increases ROS and inhibits steroid hormone-mediated upregulation of Ca2+-activated K+ channel function in uterine arteries. Hypertension 64: 415-422, 2014.   PMCID: PMC4378563 (2014)
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• González P, Li Y, Martinez F., Zhang L. Dexamethasone Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats via Activation of L­PGDS-dependent PGD2-DP1-pERK Signaling Pathway. PLoS One 9: e114470, 2014. PMCID: PMC4256424 (2014)
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• Paradis A, Zhang L. Role of endothelin in uteroplacental circulation and fetal vascular function. Curr Vascu Pharmacol 11: 594-605, 2013. PMCID: PMC3914771 (2013)
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• Xiong F, Zhang L. Role of hypothalamic-pituitary-adrenal axis in developmental programming of health and disease. Frontiers in Neuroendocrinology 34: 27-46, 2013. PMCID: PMC3594480 (2013)
• Chen M, Xiong F, Zhang L. Promoter methylation of Egr-1 site contributes to fetal hypoxia-mediated PKCε gene repression in the developing heart. Am J Physiol Regul Integr Comp Physiol 304: R683-R689, 2013.  PMCID: PMC3652077 (2013)
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• Zhu R, Hu XQ, Xiao D, Yang S, Wilson SM, Longo LD, Zhang L. Chronic hypoxia inhibits pregnancy-induced upregulation of SKCa channel expression and function in uterine arteries. Hypertension 62: 367-374, 2013.  PMCID: PMC3806070 (2013)
• Mao C, Liu R, Li S, Bo L, Chen N, Xia S, Chen J, Li D, Zhang L, Xu Z. High salt diets during pregnancy affected fetal and offspring renal renin-angiotensin system. J Endocrinol 218: 61-73, 2013. PMCID: PMC4406098 (2013)
• Zhou J, Xiao D, Hu Y, Wang J, Paradis A, MataGreenwood E, Zhang L. Gestational hypoxia induces preeclampsia-like symptoms via heightened endothelin-1 signaling in pregnant rats. Hypertension 62: 599-607, 2013.  PMCID: PMC3826959 (2013)
• Li Y, Xiao D, Yang S, Zhang L. Promoter methylation suppresses AT2R gene and increases brain hypoxic-ischemic injury in neonatal rats. Neurobiol Dis 60: 32-38, 2013. PMCID: PMC3813604 (2013)
• Xiao D, Hu XQ, Huang X, Wilson S, Yang S, Zhang L. Chronic hypoxia during gestation enhances uterine arterial myogenic tone via heightened oxidative stress. PLoS One 8: e73731, 2013. PMCID: PMC3774750 (2013)
• Hu X, Xiao D, Zhu R, Huang X, Yang S, Wilson S, Zhang L. Chronic hypoxia suppresses pregnancy-induced upregulation of large conductance Ca2+-activated K+ channel activity in uterine arteries. Hypertension 60: 214-222, 2012. PMCID: PMC3562497 (10/2012)
• Li Y, Xiao D, Dasgupta C, Xiong F, Tong W, Yang S, Zhang L. Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. Stroke 43: 2483-2490, 2012. PMCID: PMC3429721 (2012)
• Dasgupta C, Chen M, Zhang H, Yang S, Zhang L. Chronic hypoxia during gestation causes epigenetic repression of ERa gene in ovine uterine arteries via heightened promoter methylation. Hypertension, 60: 697-704, 2012. PMC: PMC3421058 (2012)
• Xiao D, Huang X, Zhang L. Chronic hypoxia differentially up-regulates PKC-mediated ovine uterine arterial contraction via actin polymerization signaling in pregnancy. Biol Reproduc 87(6):142, 1–9, 2012. PMCID: PMC4435429 (2012)
• Tong W, Zhang L. Fetal Hypoxia and Programming of Matrix Metalloproteinases Drug Discovery Today 17: 124-134, 2012. PMCID: PMC3248990 (2012)
• Shi L, Mao C, Zeng F, Zhang L, Xu Z. Central angiotensin I increases fetal swallowing activity and oxytocin release in near-term ovine fetus. Neuroendocrinology 95: 248-256, 2012. PMCID: PMC3701448 (2012)
• Patterson AJ, Xiao D, Xiong F, Dixon B, Zhang L. Hypoxia-derived oxidative stress mediates epigenetic repression of PKCε gene in foetal rat hearts. Cardiovas Res 93: 302-310, 2012. PMCID: PMC3258654 (2012)
• Xiong F, Xiao D, Zhang L. Norepinephrine causes epigenetic repression of PKCε gene in rodent hearts by activating Nox1-dependent reactive oxygen species production. FASEB J 26: 2753-2763, 2012. PMCID: PMC3382091 (2012)
• Hu X, Zhang L. Function and regulation of large conductance Ca2+-activated K+ channel in vascular smooth muscle Cells. Drug Discovery Today 17: 974-987, 2012. PMCID: PMC3414640 (2012)
• Li Y, Gonzale P, Zhang L. Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions. Progress in Neurobiology 98: 145-165, 2012. PMCID: PMC3404248 (2012)
• Dasgupta C, Xiao D, Xu Z, Yang S, Zhang L. Developmental nicotine exposure results in programming of alveolar simplification and interstitial pulmonary fibrosis in adult male rats. Reproduc Toxicol 34: 370– 377, 2012. PMCID: PMC3432662 (2012)
• Lawrence J, Chen M, Xiong F, Xiao D, Zhang H, Buchholz JN, Zhang L. Fetal nicotine exposure causes PKCe gene repression by promoter methylation in the heart. Cardiovas Res 89: 89-97, 2011.  PMCID: PMC3002869 (2011)
• Xue Q, Dasgupta C, Chen M, Zhang L. Foetal hypoxia increases cardiac AT(2)R expression and subsequent vulnerability to adult ischaemic injury. Cardiovas Res 89: 300-308, 2011. PMCID: PMC3020132 (2011)
• Dasgupta C, Zhang L. Angiotensin II receptors and drug discovery in cardiovascular disease. Drug Discovery Today 16: 22-34, 2011. PMCID: PMC3022115 (2011)
• Wu L, Mao C, Liu Y, Shi A, Xu F, Zhang L, Xu Z. Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose. Peptides 32: 104-111, 2011.   PMCID: PMC3010528 (2011)
• Zhang H, Fan Y, Xia F, Geng C, Mao C, Jiang S, He R, Zhang L, Xu Z. Prenatal water deprivation alters brain angiotensin system and dipsogenic changes in the offspring. Brain Res 1382: 128-36, 2011. PMCID: PMC3272700 (2011)
• Xiao D, Huang, X, Yang S, Zhang L. Antenatal nicotine induces heightened oxidative stress and vascular dysfunction in rat offspring. Br J Pharmacol 164: 1400-1409, 2011. Selected for Press Release, and with an editorial comment. PMCID: PMC3221095 (2011)
• Hu X, Xiao D, Zhu R, Huang X, Yang S, Wilson S, Zhang L. Pregnancy upregulates large-conductance Ca2+-activated K+ channel activity and attenuates myogenic tone in uterine arteries. Hypertension 58: 1132-1139, 2011. PMCID: PMC3223357 (2011)
• Tong W, Xue Q, Li Y, Zhang L. Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats. Am J Physiol Heart Circ Physiol 301: H2113-2121, 2011.  PMCID: PMC3213965 (2011)
• Chen M, Zhang L. Epigenetic mechanisms in fetal programming of adult disease. Drug Discovery Today 16: 1007-1018, 2011. PMCID: PMC3226870 (2011)
• Mao C, Ding Y, Zhou, Zhang H, Xu Z, Zhang L. Changes of renal AT1/AT2 receptors and structures in ovine fetuses following exposure to long-term hypoxia. Am J Nephrol, 31: 141-150, 2010.  PMCID: PMC2853592 (2010)
• Geng C, Mao C, Wu L, Cheng Y, Liu R, Chen B, Chen L, Zhang L, Xu Z. Cholinergic signal activated renin angiotensin system associated with cardiovascular changes in the ovine fetus. J Perinat Med 38: 71-76, 2010. PMCID: PMC3009554 (2010)
• Shi L, Mao C, Xu Z, Zhang L. Angiotensin converting enzymes and drug discovery in cardiovascular diseases.  Drug Discovery Today 15: 332-341, 2010. PMCID: PMC3005694 (2010)
• Tong W, Chen W, Ostrowski RP, Ma Q, Souvenir R, Zhang L, Zhang JH, Tang J. Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats. Dev Neurobiol 70: 182-94, 2010. PMCID: PMC2819408 (2010)
• Goyal R, Mittal A, Chu N, Zhang L, Longo LD. Alpha1-adrenergic receptor subtype function in fetal and adult cerebral arteries. Am J Physiol Heart Circ Physiol 298: H1797-H1806, 2010. PMCID: PMC2886655 (2010)
• Xiao D, Huang X, Longo LD, Zhang L. PKC regulates a1-adrenoceptor-mediated contractions and baseline Ca2+ sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia. High Altitude Med Biol 11: 153-162, 2010. PMCID: PMC3114155 (2010)
• Patterson A, Zhang L. Hypoxia and fetal heart development. Current Molecular Medicine, Invited Review, 10: 653-666, 2010. PMCID: PMC3075953 (2010)
• Patterson AJ, Chen M, Xue Q, Xiao D, Zhang L. Chronic hypoxia induces epigenetic programming of PKCe gene repression in fetal rat heart. Circ Res 107: 365-373, 2010. PMCID: PMC2919213 (2010)
• Chang K, Xiao D, Huang X, Xu Z, Yang S, Longo LD, Zhang L. Chronic hypoxia inhibits sex steroid hormone-mediated attenuation of ovine uterine arterial myogenic tone in pregnancy. Hypertension 56: 750-757, 2010. PMCID: PMC2940959 (2010)
• Monau TR, Vargas VE, Zhang L, Myers DA, Ducsay CA. Nitric oxide inhibits ACTH-induced cortisol production in near term, long-term hypoxic ovine fetal adrenocortical cells. Reprod Sci 17: 955-962, 2010.  PMCID: PMC2943550 (2010)
• Charles SM, Zhang L, Cipolla MJ, Buchholz JN, Pearce WJ. Roles of cytosolic Ca2+ concentration and myofilament Ca2+ sensitization in age-dependent cerebrovascular myogenic tone. Am J Physiol Heart Circ Physiol 299: H1034-H1044, 2010. PMCID: PMC2957359 (2010)
• Goyal R, Mittal A, Chu N, Arthur RA, Zhang L, Longo LD.  Maturation and long term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility.  Am J Physiol Regul Integr Comp Physiol 299: R1377-R1386, 2010. PMCID: PMC2980463 (2010)
• Xiao D, Longo LD, Zhang L. Role of KATP and L-type Ca2+ Channel Activities in Regulation of Ovine Uterine Vascular Contractility: Effect of Pregnancy and Chronic Hypoxia. Am J Obstet Gynecol 203: 596.e6-596.e12, 2010.  PMCID: PMC2993850 (2010)
• Xu F, Mao C, Ding Y, Rui C, Wu L, Shi A, Zhang L, Xu Z. Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Current Medicinal Chemistry 17: 4052-4071, 2010. PMCID: PMC3003592 (2010)
• Xiao D, Huang X, Yang S, Longo LD, Zhang L. Pregnancy downregulates actin polymerization and pressure-dependent myogenic tone in ovine uterine arteries. Hypertension 56: 1009-1015, 2010. PMCID: PMC3001123 (2010)
• Meyer K, Zhang L. Short and long-term adverse effects of cocaine abuse during pregnancy on the heart development. Ther Adv Cardiovasc Dis, 3: 7-16, 2009. PMCID: PMC2710813 (2009)
• Zhang H, Meyer K, Zhang L. Fetal cocaine exposure causes programming of Prkce gene repression in the left ventricle of adult offspring. Biol Reprod 80: 440-448, 2009. PMCID: PMC2710387 (2009)
• Mao C, Shi L, Xu F, Zhang L, Xu Z. Development of fetal brain renin-angiotensin system and its influence on programmed hypertension in fetal origins. Prog Neurobiol 87: 252-263, 2009. PMCID: PMC2819272 (2009)
• Mao C, Xiao D, Zhu L, Ding Y, Xu Z, Zhang L. The effect of fetal and neonatal nicotine exposure on renal development of AT1 and AT2 receptors. Reproductive Toxicology 27: 149-154, 2009. PMCID: PMC2692029 (2009)
• Meyer K, Zhang H, Zhang L. Prenatal cocaine exposure abolished ischemic preconditioning-induced protection in adult male rat hearts: Role of PKCe. Am J Physiol Heart Circ Physiol 296: H1566-H1576, 2009. PMCID: PMC2685332 (2009)
• Xiao D, Huang X, Xu Z, Yang S, Zhang L. Prenatal cocaine exposure differentially causes vascular dysfunction in adult offspring. Hypertension 53: 937-943, 2009. PMCID: PMC2698595 (2009)
• Xiao D, Huang X, Yang S, Zhang L. Direct chronic effect of steroid hormones in attenuating uterine arterial myogenic tone: role of PKC/ERK1/2. Hypertension 54: 352-358, 2009. PMCID: PMC2747640 (2009)
• Chang K, Xiao D, Huang X, Longo LD, Zhang L. Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway. Am J Physiol Heart Circ Physiol. 296: H1840-H1849, 2009. PMCID: PMC2716099 (2009)
• Xue Q, Zhang L. Fetal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: Role of PKCe. J Pharmacol Exp Ther 330: 624-632, 2009. PMCID: PMC2713094 (2009)
• Guan J, Mao C, Xu F, Zhu L, Liu Y, Geng C, Zhang L, Xu Z. Low doses of nicotine-induced fetal cardiovascular responses, hypoxia, and brain cellular activation in ovine fetuses. Neurotoxicology 30: 290-297, 2009. PMCID: PMC2831463 (2009)
• Meyer K, Zhang H, Zhang L. Direct effect of cocaine on epigenetic regulation of PKCε gene repression in the fetal rat heart. J Mol Cell Cardiol 47: 504-511, 2009. PMCID: PMC2739252 (2009)
• Xu F, Mao C, Liu Y, Wu L, Xu Z, Zhang L. Losartan chemistry and its effects via AT1 mechanisms in the kidney. Current Medicinal Chemistry 16: 3701-3715, 2009. PMCID: PMC2819278 (2009)
• Xu F, Mao C, Hu Y, Rui C, Xu Z, Zhang L. Cardiovascular effects of losartan and its relevant clinical application. Current Medicinal Chemistry 16: 3841-3857, 2009. PMCID: PMC2819278 (2009)
• Xiao D, Yang S, Zhang L. Prenatal cocaine exposure causes sex-dependent impairment in the myogenic reactivity of coronary arteries in adult offspring. Hypertension 54: 1123-1128, 2009. PMCID: PMC2768326 (2009)
• Goyal R, Mittal A, Chu N, Shi L, Zhang L, Longo LD. Maturation and the role of PKC-mediated contractility in ovine cerebral arteries. Am J Physiol Heart Circ Physiol. 297: H2242-H2252, 2009. PMCID: PMC2853592 (2009)
• Zhang H, Zhang L. Role of PKC isozymes in the regulation of α1-adrenoceptor-mediated contractions in the uterine arteries. Biol Reprod, 78: 35-42, 2008.  PMCID: PMC2391137 (2008)
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• Xiao D, Xu Z, Huang X, Longo LD, Yang S, Zhang L. Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin II in adult offspring. Hypertension 51: 1239-1247, 2008.   PMCID: PMC2424109 (2008)
• Xue Q, Ducsay CA, Longo LD, Zhang L. Effect of long-term high altitude hypoxia on fetal pulmonary vascular contractility. J Appl Physiol 104: 1786-1792, 2008. PMID: 18388246 (2008)
• Mao C, Yuan X, Zhang H, Lv J, Guan J, Miao L, Chen L, Zhang Y, Zhang L, Xu Z. The effect of prenatal nicotine on mRNA of central cholinergic markers and hematological parameters in rat fetuses. Int J Dev Neurosci 26: 467-475, 2008. PMCID: PMC2632976 (2008)
• Chang K, Zhang L. Steroid hormones and uterine vascular adaptation to pregnancy. Reproductive Sciences, 15: 336-348, 2008.  PMCID: PMC2408771 (2008)
• Lv J, Mao C, Zhu L, Zhang H, Pengpeng H, Xu F, Liu Y, Zhang L, Xu Z. Effects of prenatal nicotine on expression of nicotine receptor subunits in the fetal brain. Neurotoxicology, 29: 722-726, 2008. PMCID: PMC2605842 (2008)
• Zhang L, Xiao D, Hu X. Effect of cGMP on pharmacomechanical coupling in the uterine artery. J Pharmacol Exp Ther 327: 425-431, 2008. PMCID: PMC2574952 (2008)
• Mao C, Zhang H, Xiao D, Zhu L, Ding Y, Zhang Y, Wu L, Xu Z, Zhang L. Perinatal nicotine exposure alters AT1 and AT2 receptor expression pattern in the brain of fetal and offspring rats. Brain Res 1243: 47-52, 2008. PMCID: PMC2664080 (2008)
• Xiao D, Zhang L. Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain. Int J Med Sci 5: 295-302, 2008. PMCID: PMC2574017 (2008)
• Xiao DL, Zhang L. High altitude and pregnancy: adaptation of the uterine artery. In “Life on the Qinghai-Tibetan Plateau: Proceedings of the 6th World Congress on Mountain Medicine and High-Altitude Physiology” Chapter 4, pp238-245, Peking University Medical Press, 2007. (2007)
• Zhang H, Zhang L. Regulation of a1-adrenoceptor-mediated contractions of the uterine artery by PKC: role of the thick and thin filament regulatory pathways. J Pharmacol Exp Ther, 322: 1253-1260, 2007. PMID: 17562849 (2007)
• Jonker SS, Zhang L, Louey S, Giraud GD, Thornburg KL, Faber JJ. Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart. J Appl Physiol 102: 1130-1142, 2007. PMID: 17122375 (2007)
• Xiao D, Huang X, Lawrence J, Yang S, Zhang L. Fetal and neonatal nicotine exposure differentially regulates vascular contractility in adult male and female offspring. J Pharmacol Exp Ther 320: 654-661, 2007. PMID: 17068201 (2007)
• Zhang H, Darwanto A, Linkhart T, Sowers LC, Zhang L. Maternal cocaine administration causes an epigenetic modification of PKCe gene expression in fetal rat heart. Mol Pharmacol 71: 1319-1328, 2007.  PMID: 17202284 (2007)
• Xiao D, Huang XH, Yang S, Zhang L. Direct effects of nicotine on the contractility of the uterine artery in pregnancy. J Pharmacol Exp Ther 322: 180-185, 2007. PMID: 17403992 (2007)
• Charles SM, Zhang L, Longo LD, Buchholz JN, Pearce WJ. Postnatal Maturation Attenuates Pressure-Evoked Myogenic Tone and Stretch-Induced Increases in Ca2+ in Rat Cerebral Arteries. Am J Physiol Regul Integr Comp Physiol 293: R737-R744, 2007.  PMID: 17553845 (2007)
• Meyer K, Zhang L. Fetal programming of cardiac function and disease. Reproductive Sciences, 14: 209-216, 2007. PMID: 17636233 (2007)
• Xiao D, Buchholz JN, Zhang L. Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway. Am J Physiol Heart Circ Physiol 290: H2337-H2343, 2006. PMID: 16399857 (2006)
• Xiao D, Huang X, Longo LD, Pearce WJ, Zhang L. Regulation of baseline Ca2+ sensitivity in permeabilized uterine arteries: effect of pregnancy. Am J Physiol Heart Circ Physiol 291: H413-H420, 2006. PMID: 16501025 (2006)
• Williams JM, White CR, Chang MM, Injeti ER, Zhang L, Pearce WJ. Chronic hypoxic decreases in soluble guanylate cyclase protein and enzyme activity are age-dependent in fetal and adult ovine carotid arteries. J Appl Physiol 100: 1857-1866, 2006. PMID: 16469937 (2006)
• Wise A, Yang S, Zhang L. Fetal Origins of Cardiovascular Disease. Current Cardiology Reviews 2: 227-236, 2006. (2006)
• Zhang H, Xiao DL, Longo L, Zhang L. Regulation of a1-adrenoceptor-mediated contractions of the uterine artery by PKC: effect of pregnancy. Am J Physiol Heart Circ Physiol 291: H2282-H2289, 2006. PMID: 17562849 (2006)
• Bae S, Zhang L. Prenatal cocaine exposure increases apoptosis of neonatal rat heart and heart susceptibility to ischemia/reperfusion injury in one-month-old rat. Br J Pharmacol 144: 900-907, 2005. With Editorial Comment.  PMCID: PMC1576080 (2005)
• Zhang L. Prenatal hypoxia and cardiac programming.  J Soc Gynecol Invest 12: 2-13, 2005. PMID: 15629664 (2005)
• Li G, Xiao YH, Zhang L. Cocaine induces apoptosis in fetal rat myocardial cells through the p38 MAPK and mitochondrial/cytochrome c pathways. J Pharmacol Exp Ther 312: 112-119, 2005. PMID: 15365088 (2005)
• Xiao D, Zhang L. Adaptation of uterine artery thick and thin filament regulatory pathways to pregnancy. Am J Physiol Heart Circ Physiol 288: H142-148, 2005. PMID: 15358611 (2005)
• Xiao D, Longo LD, Zhang L. a1-Adrenoceptor-mediated phosphorylation of MYPT1 and CPI-17 in the uterine artery: role of ERK/PKC. Am J Physiol Heart Circ Physiol 288: H2828-H2835, 2005. PMID: 15665049 (2005)
• Zhao Y, Zhang L, Longo L. PKC-induced ERK1/2 interactions and downstream effectors in ovine cerebral arteries. Am J Physiol Regul Integr Comp Physiol 289: R164-R171, 2005. PMID: 15956760 (2005)
• Rejali M, Rejali AR, Zhang L, Yang S. Effects of Nicotine on the Cardiovascular System. Vascular Disease Prevention 2: 135-144, 2005. (2005)
• Bae S, Gilbert RD, Ducsay CA, Zhang L. Prenatal cocaine exposure increases heart susceptibility to ischemia/reperfusion injury in adult male but not female rats. J Physiol 565.1: 149-158, 2005. PMCID: PMC1464496 (2005)
• He J, Yang S, Zhang L. Effects of cocaine on nitric oxide production in bovine coronary artery endothelial cells.  J Pharmacol Exp Ther 314: 980-986, 2005. PMID: 15919765 (2005)
• Bae S, Zhang L. Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts. J Pharmacol Exp Ther 315:1125-1135, 2005.  PMID: 16099927 (2005)
• Xiao DL, Huang XH, Bae S, Ducsay DA, Longo LD, Zhang L. Cortisol-mediated regulation of uterine artery contractility: effect of chronic hypoxia. Am J Physiol Heart Circ Physiol 286: H716-H722, 2004.  PMID: 14551042 (2004)
• Yang S, Zhang L. Glucocorticoids and vascular reactivity. Current Vascular Pharmacology, 2: 1-12, 2004. PMID: 15320828 (2004)
• Xiao D-L, Pearce WJ, Longo LD, Zhang L. ERK-mediated regulation of uterine artery contraction: role of thick and thin filament regulatory pathways. Am J Physiol Heart Circ Physiol 286: H1615-H1622, 2004. PMID: 15072969 (2004)
• Li G, Bae S, Zhang L. Effect of prenatal hypoxia on heat stress-mediated cardioprotection in adult rat heart. Am J Physiol Heart Circ Physiol 286: H1712-H1719, 2004.  PMID: 14715507 (2004)
• Xiao DL, Zhang L. Calcium homeostasis and contractions of the uterine artery: Effect of pregnancy and chronic hypoxia. Biol Reprod 70: 1171-1177, 2004. PMID: 14681203 (2004)
• Arakawa TK, Mlynarczyk M, Kaushal KM, Zhang L, Ducsay CA. Long-term hypoxia alters myometrial calcium regulation in ovine myometrium. Biol Reprod 71: 156-162, 2004. PMID: 14985251 (2004)
• White M, Zhang L. Effects of Chronic Hypoxia on Maternal Vasodilation and Vascular Reactivity in Guinea Pig and Ovine Pregnancy. High Alt Med Biol 4: 157-169, 2003. PMID: 12855049 (2003)
• Bae S, Xiao YH, Li G, Casiano C, Zhang L. Effect of Maternal Chronic Hypoxic Exposure during Gestation on Apoptosis in Fetal Rat Heart. Am J Physiol Heart Circ Physiol 285: H983-H990, 2003. PMID: 12750058 (2003)
• Mlynarczyk M, Imamura T, Umezaki H, Kaushal KM, Zhang L, Ducsay CA. Long-term hypoxia changes myometrial responsiveness and oxytocin receptors in the pregnant ewe: differential effects on longitudinal vs. circular smooth muscle. Biol Reprod 69: 1500-1505, 2003.  PMID: 12855597 (2003)
• Zhao Y, Long W, Zhang L, Longo LD. Extracellular signal-regulated kinases and contractile responses in ovine adult and fetal cerebral arteries. J Physiol 551: 691-703. 2003. PMCID: PMC2343231 (2003)
• Zhang L. Fetal origins of adult disease. Proc West Pharmacol Soc 46: 9-10, 2003. PMID: 14699875 (2003)
• Bird IM, Zhang L, Magness RR. Possible mechanisms underlying pregnancy induced increases in uterine artery endothelial function. Am J Physiol 284: R245-R258, 2003. PMID: 12529278 (2003)
• Mbaku EM, Zhang L, Pearce WJ, Duckles SP, Buchholz J. High Altitude Chronic Hypoxia Alters the Function of NOS Neurons in Cerebral Arteries of Near-Term Fetal and Adult Sheep. J Appl Physiol 94: 724-732, 2003. PMID: 12433849 (2003)
• Li G, Xiao YH, Estrella JL, Ducsay CA, Gilbert RD, Zhang L. Effect of prenatally chronic hypoxia on heart susceptibility to ischemia/reperfusion injury in adult rat. J Soc Gynecol Invest 10: 265-274. 2003. with Editorial Comment. PMID: 12853087 (2003)
• Xiao D-L, Huang XH, Pearce WJ, Longo LD, Zhang L. Effects of cortisol on norepinephrine-mediated contractions in ovine uterine artery. Am J Physiol 284: H1142-H1151, 2003. PMID: 12531736 (2003)
• Blood AB, Zhao Y, Long W, Zhang L, Longo LD. L-type Ca2+ channels in adult and fetal cerebral arteries. Am J Physiol 282: R131-R138, 2002. PMID: 11742831 (2002)
• Xiao D-L, Huang XH, Bae S, Ducsay CA, Zhang L. Cortisol-Mediated Potentiation of Uterine Artery Contractility: Effect of Pregnancy. Am J Physiol 283: H238-H246, 2002. PMID: 12063296 (2002)
• Xiao D-L, Zhang L. ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy. Am J Physiol 282: H292-300, 2002.  PMID: 11748074 (2002)
• Long W, Zhang L, Longo LD. Fetal and adult cerebral artery KATP- and KCa-channel responses to long-term hypoxia. J Appl Physiol 92: 1692-1701, 2002. PMID: 11896039 (2002)
• Bishai JM, Meulenaar R, Penninga L, Nijland R, Gheorghe CP, Zhao Y, Buchholz JN, Zhang L, Longo LD. Pre- and post-junctional a2-adrenergic receptors in fetal and adult ovine cerebral arteries. Am J Physiol 282: R1654-R1662, 2002. PMID: 12010747 (2002)
• Nauli SM, Zhang L, Pearce WJ. Maturation depresses cGMP-mediated decreases in [Ca2+]i and Ca2+ sensitivity in ovine cranial arteries. Am J Physiol 280: H1019-H1028, 2001. PMID: 11179043 (2001)
• Angeles DM, Williams J, Purdy RE, Zhang L, Pearce WJ. Effects of maturation and acute hypoxia on receptor-IP3 coupling in ovine common carotid arteries. Am J Physiol 280: R410-R417, 2001. PMID: 11208569 (2001)
• Xiao D-L, Bird IM, Magness RR, Longo LD, Zhang L. Upregulation of eNOS in pregnant ovine uterine arteries by chronic hypoxia. Am J Physiol 280: H812-H820, 2001. PMID: 11158981 (2001)
• Xiao Y-H, Xiao D-L, He J, Zhang L. Maternal cocaine administration during pregnancy induces apoptosis in fetal rat heart. J Cardiovas Pharmacol 37: 639-648, 2001. PMID: 11392460 (2001)
• Xiao D-L, Pearce WJ, Zhang L. Pregnancy increases endothelium-dependent relaxation of ovine uterine artery: role of nitric oxide and intracellular calcium. Am J Physiol 281: H183-H190, 2001. PMID: 11406484 (2001)
• He J, Xiao Y, Zhang L. Cocaine-induced apoptosis in bovine coronary artery endothelial cells: role of nitric oxide.  J Pharmacol Exp Ther 298: 180-187, 2001. PMID: 11408540 (2001)
• Di T, Sullivan JA, Magness RR, Zhang L, Bird IM. Pregnancy-specific enhancement of agonist-stimulated ERK-1/2 signaling in uterine artery endothelial cells increases Ca2+ sensitivity of endothelial nitric oxide synthase as well as cytosolic phospholipase A2. Endocrinology 142: 3014-3026, 2001. PMID: 11416023 (2001)
• Nauli SM, Zhang L, Gerthoffer WT, Pearce WJ. Maturation attenuates the effects of cGMP on contraction, [Ca2+]i and Ca2+ sensitivity in ovine basilar arteries. Gen Pharmacol: The Vascular System 35: 1-12,2001. PMID: 11707317 (2001)
• Nauli SM, Akopov SE, Zhang L, Pearce WJ. Developmental changes in ryanodine- and IP3-sensitive Ca2+ pools in the ovine basilar artery. Am J Physiol 281: C1785-C1796, 2001. PMID: 11698236 (2001)
• Xiao Y-H, He J, Gilbert RD, Zhang L. Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway. J Pharmacol Exp Ther 292: 8-14, 2000. PMID: 10604926 (2000)
• Bird IM, Sullivan JA, Di T, Cale JM, Zhang L, Zheng J, Magness RR. Pregnancy-dependent changes in cell signaling underlie changes in differential control of vasodilator production in UAEC.  Endocrinology 141: 1107-1117, 2000. PMID: 10698187 (2000)
• He J, Xiao Y-H, Zhang L. Cocaine induces apoptosis in human coronary artery endothelial cells through a calcium-dependent pathway. J Cardiovas Pharmacol 35: 572-580, 2000. PMID: 10774788 (2000)
• Mbaku EN, Zhang L, Duckles SP, Buchholz J. Nitric oxide synthase-containing nerves facilitate adrenergic transmitter release in sheep middle cerebral arteries. J Pharmacol Exp Ther 293: 397-402, 2000. PMID: 10773008 (2000)
• Garcia F, Stiffel V, Pearce WJ, Zhang L, Gilbert R. Ca2+ sensitivity of fetal coronary arteries exposed to long-term, high altitude hypoxia. J Soc Gynecol Invest 7: 161-166, 2000. PMID: 10865183 (2000)
• Long W, Zhang L, Longo LD. Cerebral artery sarcoplasmic reticulum Ca2+ stores and contractility: changes with development. Am J Physiol 279: R860-R873, 2000. PMID: 10956243 (2000)
• Longo LD, Zhao Y, Long W, Miguel C, Windemuth RS, Cantwell AM, Nanyonga AT, Saito T, Zhang L. Dual role of protein kinase C in modulating NE-mediated pharmacomechanical coupling in fetal and adult cerebral arteries. Am J Physiol 279: R1419-R1429, 2000. PMID: 11004012 (2000)
• Angeles D, Williams J, Zhang L, Pearce WJ. Acute hypoxia modulates 5HT receptor density and agonist affinity in fetal and adult ovine carotid arteries. Am J Physiol 279: H502-H510, 2000. PMID: 10924047 (2000)
• Yang S, Bae L, Zhang L. Estrogen increases eNOS and NOx release in human coronary artery endothelium. J Cardiovas Pharmacol 36: 242-247, 2000. PMID: 10942167 (2000)
• He J, Xiao Y, Casiano C, Zhang L. Role of mitochondrial cytochrome c in cocaine-induced apoptosis in coronary artery endothelial cells. J Pharmacol Exp Ther 295: 896-903, 2000. PMID: 11082422 (2000)
• Xiao D-L, Ducsay CA, Zhang L. Chronic hypoxia and developmental regulation of cytochrome c expression in rats. J Soc Gynecol Invest 7: 279-283, 2000. PMID: 11035279 (2000)
• Long W, Zhang L, Longo LD. Cerebral artery KATP- and KCa-channel activity and contractility: changes with development. Am J Physiol 279: R2004-R2014, 2000. PMID: 11080063 (2000)
• Hu X-Q, Yang S, Pearce WJ, Longo LD, Zhang L. Effect of chronic hypoxia on a1-adrenoceptor-mediated inositol 1,4,5-trisphosphate signaling in ovine uterine artery. J Pharmacol Exp Ther 288: 977-983, 1999. PMID: 10027834 (1999)
• Xiao D-L, Liu Y, Pearce WJ, Zhang L. Endothelial Nitric Oxide Release in Isolated Perfused Ovine Uterine Arteries: Effect of Pregnancy.  Eur J Pharmacol 367: 223-230, 1999. PMID: 10078996 (1999)
• Long W, Zhao J, Zhang L, Longo LD. Role of Ca2+ channels in NE-induced increase in [Ca2+]i and tension in fetal and adult cerebral arteries.  Am J Physiol 277: R286-R294, 1999. PMID: 10409284 (1999)
• Zhang L, Xiao Y, He J. Cocaine and apoptosis in myocardial cells. Anat Rec 257: 208-216, 1999. PMID: 10620750 (1999)
• Zhang L. Adaptation of pharmacomechanical coupling of vascular smooth muscle to chronic hypoxia.  Comp Biochem Physiol 119A: 661-667, 1998. PMID: 9683404 (1998)
• Zhang L, Buxton ILO. Measurement of phosphoinositols and phosphoinositides using radio-high-performance liquid chromatography.  In “Methods in Molecular Biology: Phospholipid Signaling Protocols”, Chapter 4, pp47-63, Humana Press, 1998. PMID: 10427550 (1998)
• Zhang L. Inositol 1,4,5-trisphosphate mass assay.  In “Methods in Molecular Biology: Phospholipid Signaling Protocols”, Chapter 6, pp77-87, Humana Press, 1998. PMID: 10427552 (1998)
• Akopov SE, Zhang L, Pearce WJ. Developmental changes in myofilament calcium sensitivity in rabbit cranial arteries. Biol Neonate 74: 60-71, 1998. PMID: 9657670 (1998)
• Zhang L, Xiao D-L. Effects of chronic hypoxia on Ca++ mobilization and Ca++ sensitivity of myofilaments in the uterine artery. Am J Physiol 274: H132-H138, 1998. PMID: 9458861 (1998)
• Zhang L, Hu X-Q. Endothelium-dependent potentiation by cocaine of serotonin-induced contractions in sheep fetal umbilical artery. J Soc Gynecol Invest 5: 72-74, 1998. PMID: 9509384 (1998)
• Teng GQ, Williams J, Zhang L, Purdy R, Pearce WJ. Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.  Am J Physiol 275: R742-R753, 1998. PMID: 9728071 (1998)
• Akopov SE, Zhang L, Pearce WJ. Maturation alters the contractile role of calcium in ovine basilar arteries.  Pediatr Res 44: 154-160, 1998. PMID: 9702907 (1998)
• Akopov SE, Zhang L, Pearce WJ. Regulation of Ca2+ sensitization by protein kinase C and Rho proteins in ovine cerebral arteries: effects of artery size and age. Am J Physiol 275: H930-H939, 1998. PMID: 9724297 (1998)
• Zhang L, Hu X-Q, Longo LD. Effect of Chronic Hypoxia on Adrenoceptor Responses of Ovine Foetal Umbilical Vessels. Br J Pharmacol 125: 136-142, 1998. PMCID: PMC1565586 (1998)
• Rhee JW, Zhang L, Duscay CA: Functional determination of oxytocin affinity in near-term pregnant rat myometrium: effect of chronic hypoxia.  Eur J Pharmacol 356: 9-14, 1998. PMID: 9761418 (1998)
• Zhang L, Xiao D-L, Bouslough DB. Long-term high-altitude hypoxia increases plasma nitrate levels in pregnant ewes and their fetuses.  Am J Obstet Gynecol 179: 1594-1598, 1998. PMID: 9855603 (1998)
• Ueno N, Zhao Y, Zhang L, Longo LD. High altitude, hypoxic-induced changes in a1-adrenergic receptors and Ins(1,4,5)P3 responses in fetal and adult cerebral arteries. Am J Physiol 272: R669-R674, 1997. PMID: 9124493 (1997)
• Hu X-Q, Zhang L. Chronic hypoxia suppresses pharmacomechanical coupling of the uterine artery in near-term pregnant sheep.  J Physiol (Lond.) 499: 551-559, 1997.  PMCID: PMC1159326 (1997)
• Akopov SE, Zhang L, Pearce WJ. Physiological variations of ovine cerebrovascular calcium sensitivity: role of G-proteins.  Am J Physiol 272: H2271-H2281, 1997.  PMID: 9176295 (1997)
• Akopov SE, Zhang L, Pearce WJ. Mechanisms of platelet-induced angiospastic disorders: potentiation of calcium sensitivity. Can J Physiol Pharmacol 75: 849-852, 1997. PMID: 9315353 (1997)
• Zhou L, Zhao Y, Nijland R, Zhang L, Longo LD. Ins(1,4,5)P3 Receptors in Cerebral Arteries: Changes With Development and High-Altitude Hypoxia. Am J Physiol 272: R1954-R1959, 1997. PMID: 9227613 (1997)
• Rhee JW, Zhang L, Duscay CA. Suppression of myometrial contractile responses to oxytocin following different durations of chronic hypoxia in the near-term pregnant rat. Am J Obstet Gynocol 177: 639-644, 1997. PMID: 9322636 (1997)
• Longo LD, Ueno N, Zhao Y, Zhang L, Pearce WJ. Correlation of norepinephrine-induced contraction, α1-adrenergic receptors, and inositol 1,4,5-trisphosphate responses in ovine cerebral arteries. Am J Physiol 270: H915-H923, 1996. PMID: 8780186 (1996)
• Hu X-Q, Longo LD, Gilbert RD, Zhang L. Effects of long-term high altitude hypoxemia on α1-adrenergic receptors in the ovine uterine artery: functional and binding studies. Am J Physiol 270: H1001-H1007, 1996. PMID: 8780196 (1996)
• Zhang L. Muscarinic receptors in developing rat colon.  Eur J Pharmacol 304: 211-219, 1996. PMID: 8813604 (1996)
• Longo LD, Ueno N, Zhao Y, Pearce WJ, Zhang L. Developmental changes in a1-adrenergic receptors, IP3 responses, and NE-induced contraction in cerebral arteries. Am J Physiol 271: H2313-H2319, 1996. PMID: 8997288 (1996)
• Akopov SE, Zhang L, Pearce WJ. Intracranial-extracranial differences in the Ca2+ sensitivity of rabbit arteries. Soc Exp Biol Med 214: 76-82, 1996. PMID: 9012364 (1996)
• Zhang L, Pearce WJ, Longo LD. Noradrenaline-mediated contractions of ovine uterine artery: Role of inositol 1,4,5-trisphosphate. Eur J Pharmacol (Mol Pharmacol Section) 289: 375-382, 1995. PMID: 7621912 (1995)
• Zhang L, Chang JHS. Development-related changes in colon muscarinic receptors. Proc West Pharmacol So. 38: 107-110, 1995. PMID: 7480000 (1995)
• Zhang L, Dyer DC, Fiscus RR, Grujic Z, Wang X. 5-Hydroxytryptamine induces endothelium-independent relaxation of ovine pulmonary vein: Role of cAMP. Eur J Pharmacol 280: 335-337, 1995. PMID: 8566103 (1995)
• Zhang L, Hu X-Q. Serotonin stimulates rapid formation of inositol 1,4,5-trisphosphate in ovine uterine artery: Correlation with contractile state.  J Pharmacol Exp Ther 275: 576-583, 1995. PMID: 7473141 (1995)
• Zhang L, Bradley ME, Buxton ILO. Inositol polyphosphate binding sites and their likely role in calcium regulation in smooth muscle. Int J Biochem Cell Biol 27: 1231-1248, 1995. PMID: 8581820 (1995)
• Zhang L, Buxton ILO. Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle. Br J Pharmacol 108: 613-621, 1993. PMCID: PMC1908018 (1993)
• Zhang L, Dyer DC. Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in the ovine uterine artery of late pregnancy. Eur J Pharmacol 230: 115-117, 1993. PMID: 8428600 (1993)
• Smith TK, Ward SW, Zhang L, Buxton ILO, Gerthoffer WT, Sanders KM, Keef KD. ß-Adrenergic inhibition of electrical and mechanical action in canine colon: Role of cyclic AMP.  Am J Physiol 264: G708-G717, 1993. PMID: 8386465 (1993)
• Zhang L, Bradley ME, Khoyi M, Westfall DP, Buxton ILO. Characterization of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate binding sites in canine colonic circular smooth muscle. Br J Pharmacol 109: 905-912, 1993.  PMCID: PMC2175757 (1993)
• Khoyi MA, Dalziel HH, Bjur RA, Gerthoffer WT, Zhang L, Buxton ILO, Westfall DP. [Ca2+]i-sensitive, IP3-independent Ca2+ Influx in Smooth Muscle of Rat Vas Deferens Revealed by Procaine . Br J Pharmacol 110: 1353-1358, 1993. PMCID: PMC2175887 (1993)
• Zhang L, Keef KD, Bradley ME, Buxton ILO. The action of α2A-adrenergic receptors in the circular smooth muscle of canine proximal colon.  Am J Physiol 262: G517-G524, 1992. PMID: 1312795 (1992)
• Ozaki H, Zhang L, Buxton ILO, Sanders KM, Publicover NG. Phosphatydyl inositol-turnover: a negative feed-back mechanism for excitation-contraction coupling in gastric smooth muscle. Am J Physiol 263: C1160-C1171, 1992. PMID: 1476162 (1992)
• Zhang L, Dyer DC. Characterization of α-adrenoceptor mediating contraction in isolated ovine umbilical vein.  Eur J Pharmacol 197: 63-67, 1991. PMID: 1680054 (1991)
• Zhang L, Dyer DC, Hembrough FB, Isla M. Effects of R(-)2,5-dimethoxy-4-methyl-amphetamine (DOM) on uterine and umbilical blood flow in conscious pregnant sheep. Eur J Pharmacol 199: 179-184, 1991. PMID: 1954976 (1991)
• Zhang L, Dyer DC. 5-HT2 Receptor stimulated calcium influx in ovine uterine artery in late pregnancy. Arch Int Pharmacodyn Ther 310: 46-55, 1991. PMID: 1772330 (1991)
• Zhang L, Horowitz B, Buxton ILO. Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes. Mol Pharmacol 40: 943-951, 1991. PMID: 1758444 (1991)
• Zhang L, Buxton ILO. Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways coupled to the muscarinic receptors.  Mol Pharmacol 40: 952-959, 1991. PMID: 1661840 (1991)
• Zhang L, Dyer DC. Characterization of 5-hydroxytryptamine receptors on isolated ovine uterine artery in late pregnancy. J Pharmacol Exp Ther 253: 1236-1244, 1990. PMID: 2359025 (1990)
• Zhang L, Dyer DC. Characterization of serotonergic receptors mediating contraction of ovine umbilical artery. J Pharmacol Exp Ther 255: 233-239, 1990.  PMID: 2213559 (1990)
• Zhang L, Dyer DC. 5-HT receptor mediated vasoconstriction in the ovine fetal umbilical vein. Eur J Pharmacol 184: 281-293, 1990. PMID: 2213559 (1990)
• Dyer DC, Zhang L, Hembrough FB, Isla M.  Hemodynamic responses to cocaine in the pregnant ewe and fetus: Effects of prazosin. Eur J Pharmacol 183: 819-820, 1990. (1990)