Scholarly Journals--Published

  •  Haug S,  St. Peter S, Ramlogan S, Goff  D, Thorpe D,  Hopper A,  Baerg J. The impact of breast milk, respiratory insufficiency and GERD on enteral feeding in infants with omphalocele. JPGN Publish Ahead of Print. 2016 Nov 5.     Objectives: The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success.Methods: After Institutional Review Board approval (5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. Mortalities were excluded. All survivors had complete follow-up. Variables suspected to impact enteral feeding in infants with non-giant versus giant omphalocele were compared. Independent t-test, Mann-Whitney and chi-square test were utilized. Regression evaluated for variable independence. Results: Of 123 infants with omphalocele, 97 (79%) survived, 62/97 (64%) had non-giant and 35/97 (36%) giant omphalocele. For survivors, the mean gestational age was 37+/-4 weeks with median follow-up of 4.4 years (range: 1.4 to 7.4 years). The median time to full feeds was 4 days (range: 0 to 85 days) for non-giant versus 8 days (range: 1 to 96 days) for giant, a significant difference (p<0.01). Breast milk significantly decreased time to full feeds independent of omphalocele size. Giant omphalocele infants had a significantly higher incidence of respiratory insufficiency at birth (p<0.01) and sac rupture (p=0.02), but fewer chromosomal anomalies (p=0.04). Respiratory insufficiency at birth (p<0.01) and gastroesophageal reflux disease (GERD) (p <0.01) independently delayed feeding in omphalocele infants. Conclusions: Infants with non-giant omphalocele can achieve full enteral feeds within the first week of life, but giant omphalocele infants require significantly more time. Breast milk independently promotes feeding success while GERD and respiratory insufficiency at birth independently delay feeding in infants with omphalocele. (11/2016)
  • Lousuebsakul-Matthews V, Thorpe DL, Knutsen R, Beeson WL, Fraser GE, Knutsen SK.  Legumes and meat analogues consumption are associated with hip fracture risk independently of meat intake among Caucasian men and women: the Adventist Health Study-2. Pub Health Nut 2013; (12/2013)
  • Rendon AA, Lohman EB, Thorpe D, Johnson EG, Medina E, Bradley B. The effect of virtual reality gaming on dynamic balance in older adults. Age and Ageing. 2012;41(4):549-552. (Present - 10/2012)
  • Martin BD, Thorpe DL, Merenda V, Finch B, Anderson-Smith W, Consiglio-Lahti Z.  Contrast in usage of FCAT-approved anatomical terminology between members of two anatomy associations in North America.  Anat. Sci. Educ. 2010;3:25-32. (Present - 07/2010)
  • Martin B, Thorpe D, Barnes R, DeLeon M, Hill D.  Frequency in usage of FCAT approved anatomical terms by American Association of Anatomists.  Anat. Sci. Educ. 2009; 2(3):94-106.  (Present - 07/2009)
  • Lohman EB III, Thorpe DL, Prior M, George J, Kim JP. Can APB 2000 be used to discern sincerity of effort in unimpaired subjects from maximal performance in subjects with shoulder pain?  J Forensic Sci.  2008;53(2):392-6. The automated pegboard (APB 2000), which has been found to objectively quantify motor performance, was used to differentiate maximal motor performane among subjects with shoulder pain, healthy unimpaired subjects performing normally and also while feigning shoulder pain.  Six participants with shoulder pain and 15 healthy unimpaired individuals particdipated.  Individuals with shoulder pain were tested on the APB 2000 using their affected upper extremity.  Unimpaired participants were instructed to perform normally on the test with randomly selected upper extremity and to feign shoulder pain with the other upper extremity.  The two tests for the unimpaired participants were conducted 1 week apart.  There were significant differences in mean performance time for normal, patient, and feigned performance, with 80, 111 and 149 sec for the three groups respectively (p<0.0005).  There was also considerable overlap in the three distributions of performance times.  These preliminhary findings suggest that the APB 2000 is able to distinguish performance time between theses three groups.  Whether it can be used to distinguish between maximal performance and submaximal performance in individuals suspected of submaximal performance requires further study. (Present - 09/2008)
  • Lohman III EB, Petrofsky JS, Malloney-Hinds C, Betts-Schwab H, Thorpe D. "The effect of whole body vibration on lower extremity." Medical Science Monitor 13.2 (2007): 71-76. Background: Circulation plays a vital role in tissue healing. Increases in muscle fl exibility and strength, secretion of hormones important in the regeneration and repair process, blood fl ow, and strength of bone tissues has been attributed to whole body vibration (WBV) combined with exercise. The purpose of the study was to determine the effects of short-duration, high-intensity, isometric weight bearing exercise (vibration exercise [VE]) and vibration only on skin blood fl ow (SBF). Material/Methods: Forty-fi ve subjects 18?43 years of age were randomly divided into three groups: Group 1 ? VE, Group 2 ? exercise only, and Group 3 ? vibration only. SBF was measured using a laser Doppler imager at three time intervals: 1) initial base line, 2) immediately following intervention, and 3) 10-minutes following intervention. Results: There was no signifi cant difference between the three groups? SBF prior to intervention. Immediately following the intervention a difference among groups was found. Post hoc testing revealed that Group 3 subjects? mean SBF was signifi cantly increased at both post-intervention time intervals. Conclusions: The study fi ndings suggest that short duration vibration alone signifi cantly increases SBF; doubling mean SBF for a minimum of 10 minutes following intervention. The emerging therapeutic modality of WBV as a passive intervention appears to increase SBF in individuals with healthy microcirculation (Present - 01/2007)
  • Thorpe DL, Knutsen SK, Beeson WL, Rajaram S. "Effects of meat consumption and vegetarian diet on risk of wrist fracture over 25 years in a cohort of peri- and postmenopausal women." Public Health Nutrition 2008;11(6): 564-572. Background. Evidence that suggests a diet high in fruits and vegetables may be beneficial to bone health has sparked interest in the potential benefit of a vegetarian diet in this regard. However, other studies have raised a question regarding the adequacy of protein in such a diet Objective. The aim of this study was to take a whole foods approach in examining the effects of foods high in protein on the risk of a wrist fracture (WF) in a cohort with a significant proportion consuming a meat free diet. Design. A cohort of 1865 peri and postmenopausal women completed two lifestyle questionnaires 25 years apart. The first questionnaire contained 65 food frequency items. The second captured occurrence of low trauma fractures during the intervening 25 years. Results. Higher cheese consumption more than 3x/week was associated with a decreased risk of WF (hazard ratio (HR)=.43 (95% CI 0.18-.98) in multivariable adjusted analysis. There was also a significant interaction between meat consumption and foods high in vegetable protein. For subjects consuming a meat free diet, increasing levels of plant based high protein foods decreased risk of WF. For those consuming meat, the effect of increasing meat consumption was variable, depending on vegetable protein foods consumption. Conclusions. Among vegetarians increased intake of foods high in vegetable protein (beans, nuts, and vegetarian meat analogs) suggests the importance of adequate levels of high protein foods in the diet. The mechanism for the interaction between meat and vegetable protein foods is unknown and requires further research. (Present - 06/2008)
  • DL Thorpe, SF Knutsen, WLBeeson, GE Fraser. "The Effect of Vigorous Physical Activity and Risk of Wrist Fracture over 25-Year in a Low Risk Survivor Cohort.." Journal of Bone and Mineral Metabolism 4.6 (2006): 476-483. Abstract: Recent studies have suggested that a high level of recent physical activity increases the risk of a wrist fracture in postmenopausal women. The relationship of more distant past physical activity to wrist fracture is less clear, and most studies have relied on recall of physical activity much earlier in life. The aim of this study was to assess the risk of wrist fracture in a subset of women who had completed a recent questionnaire and also had participated in a cohort study 25 years earlier. 1865 women who were peri and postmenopausal women in 1976, completed the 1976 and 2002 Adventist Health Study lifestyle questionnaires. Data on risk factors including physical activity were collected from the 1976 survey. Subjects reported wrist fractures occurring since baseline, and the approximate time of fracture, in the 2002 questionnaire. Incidence of wrist fracture was 3.7/1000 person years of follow up. There was a dose response inverse relationship between level of physical activity and wrist fracture with a 37% reduction of risk for the highest level of physical activity with respect to the lowest level (HR 0.63, 95% CI 0.45, 0.89). The effect of physical activity changed little in the final multivariable model (HR 0.61, 95% CI 0.43, 0.87). In this cohort of women with relatively low incidence of wrist fracture, higher levels of physical activity at baseline was protective against risk of fracture over 25 years of follow-up. (Present - 11/2006) (link)
  • Godges JJ, Mattson-Bell M, Thorpe D, Shah D. "The immediate effects of soft tissue mobilization with proprioceptive neuromuscular facilitation on glenohumeral external rotation and overhead reach.." Journal of Orthopedic and Sports Physical Therapy 33.12 (2003): 713-718. Objectives: THe purpose of this study was to evaluate the immediate effect of soft tissue mobilization (STM) with proprioceptive neuromuscular facilitation (PNF) to increase glenohumeral external rotation at least 45 degrees of shoulder abduction and overhead reach. Methods and Measures: Twenty patients (10 males, 10 females; age range, 21-83 years) with limited glenohumeral external rotation and overhead reach of 1 year duration or less served as subjects. THe subjects were randomly assigned to a treatment group, which consisted of soft tissue mobilization to the subscapularis and proprioceptive neuromuscular facilitation to the shoulder rotators, or a control group. Goniometric measurements of glenohumeral external rotation at 45 degrees abduction and overhead reach were taken preintervention and immediately postintervention for the treatment group or at prerest and postrest periods for the control group. Results: The treatment group improved by a mean of 16.4 degrees (95% CI 12.5-203 degrees) of glenohumeral external rotation, as compared to less than a 1 degree gain (95% CI -.02-2.0 degrees) in the control group (p (Present - 01/2003)


  • (NON-PEER REVIEWED) Does physical therapy in the NICU affect developmental outcomes? (06/2011 - 09/2011)