Research Projects & Grants

College/University

  • Cytogenetic damage as a biomarker of radiation sensitivity in prostate cancer, Role: Co-Investigator, Columbia University, (08/2014 - 07/2015) Status: Closed

Federal

  • Cytokines, genetic background and response to low dose and simulated flare protons, Role: Investigator, National Aeronautics & Space Administration, (07/2016 - 07/2017) Status: Completed
  • A multi-center pilot study of high-dose immunoablative therapy using total body irradiation, anti-thymocyte globulin and cyclophosphamide followed by autologous transplantation with CD34 selected peripheral blood stem cells for patients with systemic sclerosis, Role: Investigator, National Institutes of Health/DHHS, (05/2005 - 05/2006) Status: Completed
  • RTOG 96-12. Phase II study of chemoradiation in patients with locally advanced epidermoid carcinoma of the vulva, Role: Investigator, National Cancer Institute/NIH/DHHS, (02/1998 - 02/1999) Status: Completed

For Profit Organization

  • GOG-263: Randomized phase III clinical trial of adjuvant radiation versus chemoradiation in intermediate risk, stage I/IIA cervical cancer treated with initial radical hysterectomy and pelvic lymphadenectomy, Role: Investigator, Southwest Oncology Group, (09/2024 - 09/2025) Status: Approved
  • SWOG 88-92. A Phase III Study of Radiotherapy With or Without Concurrent Cisplatin in Patients with Nasopharyngeal Cancer, Role: Investigator, Southwest Oncology Group, (08/2004 - 08/2005) Status: Completed
  • PROG 92-14. A phase I/II study employing proton therapy for the treatment of squamous cell carcinoma of the oropharynx, Role: PI, Proton Radiation Oncology Group, (12/1998 - 12/1999) Status: Completed

Internal

  • Phase I-II trial of stereotactic body proton therapy for patients with liver metastases, Role: Investigator, LLU Dept. of Radiation Medicine, (08/2024 - 08/2025) Status: Approved
  • A phase II trial of proton chemotherapy (PCT) for resectable esophageal or esophagogastric junction cancer, Role: Investigator, LLU Dept. of Radiation Medicine, (08/2024 - 08/2025) Status: Approved
  • Phase II trial of partial breast proton therapy for early stage breast cancer with low and intermediate risk factors, Role: Investigator, LLU Dept. of Radiation Medicine, (08/2024 - 07/2025) Status: Approved
  • Phase II trial of lumpectomy and partial breast proton therapy for early stage breast cancer, Role: Investigator, LLU Dept. of Radiation Medicine, (06/2024 - 06/2025) Status: Approved
  • Phase I-II trial of hypofractionated conformal proton beam radiation therapy for favorable-risk prostate cancer, Role: PI, LLU Dept. of Radiation Medicine, (01/2025 - 01/2026) Status: Approved
  • Radiation medicine research registry, Role: PI, LLU Dept. of Radiation Medicine, (10/2024 - 09/2025) Status: Approved
  • A phase II study of preoperative proton therapy in soft tissue sarcomas of the extremities and body wall, Role: Investigator, LLU Dept. of Radiation Medicine, (05/2022 - 05/2023) Status: Completed
  • Proton radiotherapy for isolated lymph node recurrence in gynecological cancers, Role: PI, LLU Dept. of Radiation Medicine, (02/2021) Status: Approved
  • Randomized controlled trial of transarterial chemoembolization versus proton beam radiotherapy for the treatment of hepatocellular carcinoma, Role: Investigator, LLU Dept. of Surgery, (07/2020 - 07/2021) Status: Completed
  • Cancer cell aggressiveness caused by conventional vs. proton radiation, Role: PD/PI, LLU School of Medicine, (01/2020 - 12/2023) Status: Closed
  • Retrospective study to evaluate the correlation of prostate biopsy findings with extent of disease on MRI examination in patients with prostate cancer, Role: Investigator, LLU Dept. of Radiation Medicine, (11/2017 - 11/2018) Status: Completed
  • Comparing long term overall health and well-being outcomes for breast cancer patients treated with proton or conventional radiotherapy, Role: Investigator, LLU Dept. of Radiation Medicine, (10/2015) Status: Completed
  • Proton vs. IMRT planning study for radiosurgery of brain metastasis, Role: Investigator, LLU Dept. of Radiation Medicine, (05/2015) Status: Completed
  • Adult - pediatric - CY-VP-TBI - Cyclophosphamide etoposide and total body irradiation followed by allogeneic marrow or blood stem cell transplant for the treatment of leukemia, lymphoma, or myelodysplasia, Role: Investigator, LLU Transplantation Institute, (10/2014 - 10/2015) Status: Completed
  • Correlation of radiation-induced late toxicity and T Lymphocyte apoptosis, Role: Investigator, LLU Dept. of Radiation Medicine, (12/2013 - 12/2014) Status: Completed
  • Phase I/II study of combined chemotherapy and high dose, accelerated proton radiation for the treatment of locally advanced non-small cell lung carcinoma, Role: Investigator, LLU Dept. of Radiation Medicine, (03/2013 - 03/2014) Status: Completed
  • Phase I/II study of proton beam therapy for hepatocellular carcinoma, Role: Investigator, LLU Dept. of Radiation Medicine, (10/2011 - 10/2012) Status: Completed
  • The relationship between psychological factors and support group participation in prostate cancer patients, Role: Investigator, LLU School of Public Health, (12/2009) Status: Completed

Non-Profit Organization

  • A prospective comparative study of outcomes with proton and photon radiation in prostate cancer (COMPPARE), Role: PI, Patient-Centered Outcomes Research Institute (PCORI), (08/2024 - 08/2025) Status: Approved
  • Proton Therapy to Test Intractable Pain, Role: PD/PI, Del E. Webb Foundation, (07/2016 - 06/2022) Status: Closed
  • RTOG 94-05. A phase III intergroup randomized comparison of combined modality therapy for carcinoma of the esophagus -- high dose vs. conventional dose radiation therapy, Role: PI, Radiation Therapy Oncology Group, (04/2008 - 04/2009) Status: Completed
  • RTOG 95-01. A phase III intergroup trial of surgery followed by radiotherapy vs. radiochemotherapy for resectable high risk squamous cell carcinoma of the head and neck, Role: PI, Radiation Therapy Oncology Group, (07/2007 - 07/2008) Status: Completed
  • RTOG 89-02. Phase I/II study of sphincter sparing local excision combined with post operative radiation therapy and concurrent 5-FU in the treatment of limited adenocarcinoma of the rectum, Role: PI, Radiation Therapy Oncology Group, (04/2004 - 04/2005) Status: Completed
  • Breast Cancer Protocol Development Project, Role: Principal Investigator, Hearst Foundations, (07/2002 - 06/2010) Status: Closed
  • Pediatric Epilepsy Research: Proton Radiotherapy, Role: PD/PI, Henry L. Guenther Foundation, (03/2002 - 06/2026) Status: Awarded
  • RTOG 90-06. A phase III comparison of hyperfractionated radiation therapy with BCNU and conventional RT with BCNU for supratentorial malignant glioma, Role: PI, Radiation Therapy Oncology Group, Status: Completed