Research Projects & Grants

College/University

• MVAC Based in Organ - Confirmed Bladder Cancer Based on P53 Status, Role: Principal Investigator, University of California, (03/1999 - 03/2008) Status: Closed
• Phase II trial of serum Micro RNA-371 in detecting active germ cell tumors in patients with suspected regional disease –(MAGESTIC Trial: MiRNA in detecting Active Germ cell tumors in Early Suspected and metastaTIC disease Trial), Role: Investigator, University of Southern California, (10/2024 - 10/2025) Status: Approved

For Profit Organization

• UroGen Pharma Ltd.-TC-UT-03-P: A Phase 3 multicenter trial evaluating the efficacy and safety of MitoGel™ (UGN-101) on ablation of upper urinary tract urothelial carcinoma, Role: Investigator, UroGen Ltd., (04/2020 - 04/2021) Status: Completed
• UroGen TC-BC-12: A phase 2b, Single-arm, multicenter trial to evaluate the efficacy and safety of UGN-102 as primary Chemoablative Therapy in Patients with Low Grade (LG) Non-Muscle-Invasive Bladder Cancer (NMIBC) at intermediate risk of recurrence, Role: Investigator, UroGen Ltd., (04/2020 - 04/2021) Status: Completed
• NADiA® ProsVue™ field experience trial, Role: PI, NADiA ProsVue, (09/2013 - 09/2014) Status: Completed
• A multicenter study of the efficacy and safety of interstitial laser coagulation (ILC) versus alpha-blockade in subjects with symptomatic benign prostatic hyperplasia, Role: PI, Ethicon Endo Surgery, (02/2006 - 02/2007) Status: Completed
• A multiple dose, tolerance and safety, and pharmacodynamic study of E-7869 (R-Flurbiprofen) in prostate cancer patients who have failed definitive prostate cancer treatment (but do not require hormonal treatment) or who have hormone refactory prostate cancer, Role: Investigator, Encore Pharmaceuticals, Inc., (10/2000 - 10/2001) Status: Completed
• EPR-7869-0004, Follow-on to protocol EPR-7869-003, A multiple dose, tolerance and safety, and pharmacodynamic study of E-7869 (R-Flurbiprofen) in prostate cancer patients who failed definitive treatment (but do not require hormonal treatment) or who have hormone refractory prostate cancer, Role: Investigator, Encore Pharmaceuticals, Inc., (06/2000 - 06/2001) Status: Completed
• SWOG 9407 Evaluation of oral estramustine and oral etoposide in patients with hormone refractory adenocarcinoma of the prostate, Phase II., Role: PI, Southwest Oncology Group, (04/1996 - 04/1997) Status: Completed
• A multicenter phase III randomized trial comparing docetaxel administered either weekly or every three weeks in combination with prednisone versus mitoxantrone in combination with prednisone for metastatic hormone refractory prostate cancer, Role: Investigator, Aventis Pharmaceuticals, Status: Completed
• QuadrametTM study 303521 double-blind placebo-controlled study of Samarium Sm-153 lexidronam (QuadrametTM) for the treatment of asymptomatic skeletal metastases in patients with hormone-refractory prostate carcinoma, Role: Investigator, Berlex Laboratories Inc., Status: Completed

Internal

• EVALUATING THE RELATIONSHIP BETWEEN THE MICROBIOME AND PROSTATIC DISEASE, Role: Investigator, LLU Dept. of Urology, (05/2024) Status: Approved
• Clinical Outcomes of Ureteral Stenting For Non-Urologic Procedures, Role: Investigator, LLU Dept. of Urology, (04/2024) Status: Approved
• THE EFFECT OF ILEAL MICRO BI OT A PROFILES ON POSTOPERATIVE OUTCOMES IN RADICAL CYSTECTOMY PATIENTS, Role: Investigator, LLU Dept. of Urology, (03/2024) Status: Approved
• 4T-14-1: Surgery in early metastatic seminoma (SEMS): Phase II trials of retroperitoneal lymph node dissection as first-line treatment for testicular seminoma with isolated retroperitoneal disease (1-3cm), Role: Investigator, LLU Dept. of Urology, (10/2024 - 10/2025) Status: Approved
• Radical Cystectomies: Surgical Experience Review at Loma Linda University Health from 2018 to 2021, Role: Investigator, LLU Dept. of Anesthesiology, (08/2022) Status: Approved
• Perioperative outcomes in prostatectomy patients using a novel post-operative multimodal pain control pathway utilizing buprenorphine compared to conventional opioid management, Role: Investigator, LLU Dept. of Urology, (03/2022) Status: Approved
• Efficacy of the liposomal bupivacaine for pain control following urologic procedures, Role: Investigator, LLU Dept. of Urology, (06/2021 - 06/2022) Status: Completed
• Predicting acute kidney injury in critically III patients using urinary metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP-7), Role: Investigator, LLU Dept. of Anesthesiology, (03/2021 - 03/2022) Status: Completed
• The effects of caffeine on overactive bladder symptoms and mental health in postmenopausal women, Role: Investigator, LLU Dept. of Urology, (01/2021 - 01/2022) Status: Completed
• Retrospective review of perioperative outcomes in patients after robotic prostatectomy based on the usage of the analgesic buprenorphine, Role: PI, LLU Dept. of Urology, (08/2020) Status: Approved
• PSA levels and prostate cancer detection rates in patients with end-stage renal disease, Role: Investigator, LLU Dept. of Urology, (09/2013 - 09/2014) Status: Completed
• A randomized placebo controlled study of oral anxiolytic with periprostatic block to control pain during transrectal ultrasounded guided biopsy of the prostate, Role: PI, LLU Dept. of Urology, (06/2012 - 06/2013) Status: Completed
• Massage therapy and the relationship to post-operative pain management, Role: Investigator, Loma Linda University Medical Center, (02/2012 - 02/2013) Status: Completed
• Treatment of angiomyolipomas in tuberous sclerosis patients, Role: PI, LLU Dept. of Urology, (04/2005 - 04/2006) Status: Completed
• Urothelial carcinoma and other coexisting pelvic malignancies, Role: PI, LLU Dept. of Urology, (04/2005 - 04/2006) Status: Completed
• Open label study of ambrotose in relapsed or refractory prostate cancer, Role: Investigator, LLU Dept. of Medicine, (07/2004 - 07/2005) Status: Completed
• Efficacy of flurbiprofen in the treatment of prostate cancer, Role: PI, LLU Dept. of Urology, (10/2000 - 10/2001) Status: Completed
• Prospective evaluation of interinsic sphincter function in patients after radical prostatectomy with various bladder neck reconstructive techniques, Role: PI, LLU Dept. of Urology, (08/1999 - 08/2000) Status: Completed
• Autoantibody repertoires in prostate cancer, Role: PI, LLU Dept. of Urology, Status: Completed
• LLU Cancer Center biospecimen laboratory - specimens collection protocol, Role: Investigator, LLU Cancer Institute, (09/2024 - 09/2025) Status: Approved
• Randomized Single-Blinded Trial of Patient Reported Experiences with Sparing ExteRnal Oblique Fascia Vs Standard Inguinal OrchiEctomy (PRESERVE Trial), Role: Investigator, LLU Dept. of Urology, (03/2025) Status: Approved
• Investigation on the Social and Psychological Impact of Germ Cell Testicular Cancer Among Survivors, Role: Investigator, LLU Dept. of Urology, (04/2025) Status: Approved

Non-Profit Organization

• CALGB - 70807: The men's eating and living (MEAL) study: A randomized trial of diet to alter disease progression in prostate cancer patients on active surveillance, Role: PI, The Cancer and Leukemia Group B, (07/2018 - 07/2019) Status: Completed
• Lilly Protocol B9E-MC-JHGA9c. A randomized phase 3 study of gemcitabine plus cisplatin versus MVAC chemotherpy in advanced or metastatic transitional cell carcinoma of the urothelium., Role: Investigator, Lilly Endowment, Inc., (08/1998 - 08/1999) Status: Completed