Research Projects & Grants

College/University

  • Penn State - Prospective observational database of patients with colon cancer at risk of peritoneal recurrence, Role: PI, Pennsylvania State University, (12/2024 - 12/2025) Status: Approved
  • Epigenetic Regulation in High-Risk Leukemia, Role: Co-Sponsor, Pennsylvania State University, (08/2017 - 07/2021) Status: Closed
  • ACOSOG Statistics and Data Coordinating Center, Role: Principal Investigator, Duke University, (04/2004 - 06/2018) Status: Closed

Federal

  • TSLP and pediatric leukemia mechanisms and treatment, Role: PI, National Cancer Institute/NIH/DHHS, (06/2024 - 06/2025) Status: Approved
  • Epigenetic Regulation in High-Risk Leukemia, Role: Mentor, National Cancer Institute/NIH/DHHS, (08/2020 - 07/2021) Status: Closed
  • LLU-NIH Initiative for Maximizing Student Development, Role: Other Significant Contributor, National Institute of General Medical Sciences/NIH/DHHS, (01/2018 - 12/2023) Status: Closed
  • NASBP B-27.1 A trial to evaluate the worth of serum ErbB-2 extracellular domain and serum ErbB-2 antibodies in predicting response to preoperative chemotherapy and long-term outcome in patients with operable breast cancer who are participating in NSABP Protocol B-27, Role: Investigator, National Cancer Institute/NIH/DHHS, (07/2009 - 07/2010) Status: Completed
  • NSABP C-06. A clinical trial comparing oral Uracil/Ftorafur plus leucovorin with 5-fluorouraceil (5-FU) plus leucovorin in the treatment of patients stages II and III carcinoma of the colon, Role: PI, National Cancer Institute/NIH/DHHS, (08/2008 - 08/2009) Status: Completed
  • Antibiotic Irrigation for Prophylaxis of Post-Operative Abdominal Wound Infection in Major Clean-Contaminated Colorectal Surgery., Role: Principal Investigator, Veterans Administration, (08/2004 - 06/2008) Status: Closed

For Profit Organization

  • SWOG S1316: Prospective comparative effectiveness trial for malignant bowel obstruction, Role: PI, Southwest Oncology Group, (11/2024 - 11/2025) Status: Approved
  • Caris Life Sciences® and Precision Oncology Alliance™ Retrospective Outcomes-Associated Database, Role: Investigator, Caris MPI, Inc., (02/2023) Status: Approved
  • E5202 Phase III SWOG endorsed CTSU study: a randomized phase III study comparing 5-FU, leucovorin and oxaliplatin versus 5-FU, leucovorin, oxaliptatin and bevacizumab in patients with stage II colon cancer at high risk for recurrence to determine prospectively and prognostic value of molecular markers, Role: Investigator, Southwest Oncology Group, (01/2020 - 01/2021) Status: Completed
  • SWOG - S0941: Phase II study of sorafenib (NSC-724772) and erlotinib (NSC-718781) in patients with advanced gallbladder carcinoma or cholangiocarcinoma, Role: Investigator, Southwest Oncology Group, (03/2013 - 03/2014) Status: Completed
  • NewLink Genetics Corporation - NLG-0405: A phase III study of chemotherapy and chemoradiotherapy with or without HyperAcute - pancreatic (Algenpantucel-L) immunotherapy in subjects with surgically resected pancreatic cancer, Role: Investigator, NewLink Genetics Corporation, (07/2011 - 07/2012) Status: Completed

Internal

  • Phase I-II trial of stereotactic body proton therapy for patients with liver metastases, Role: Investigator, LLU Dept. of Radiation Medicine, (08/2024 - 08/2025) Status: Approved
  • Investigator Initiated: A phase II trial of preoperative chemotherapy (with gemcitabine and nab-paclitaxel) and stereotactic body radiotherapy followed by surgery and chemotherapy in patients with resectable pancreatic adenocarcinoma, Role: Investigator, LLU Dept. of Surgery, (09/2024 - 09/2025) Status: Approved
  • A phase II study of preoperative proton therapy in soft tissue sarcomas of the extremities and body wall, Role: Investigator, LLU Dept. of Radiation Medicine, (05/2022 - 05/2023) Status: Completed
  • Incidence and Outcomes of Cervical Cancer Cases at a Rural Hospital in Malawi, Role: Investigator, LLU Dept. of Gynecology & Obstetrics, (01/2022) Status: Approved
  • Cancer care and surgical training in Africa: A needs assessment across the Pan-African Academy of Christian Surgeons (PAACS) and College of Surgeons of East, Central, and Southern Africa (COSECSA) general surgery residencies, Role: Investigator, LLU Dept. of Surgery, (10/2021 - 10/2023) Status: Approved
  • Presentation Treatment patterns and Outcomes in patients Receiving care for Esophageal Squamous Cell Cancer in a Low Resource setting; a Feasibility Study at Queen Elizabeth Central Hospital and Malamulo Adventist Hospital in Southern Malawi, Role: PD/PI, LLU - GRASP, (03/2021 - 02/2023) Status: Awarded
  • Does preoperative biopsy of retroperitoneal and extremity sarcoma change treatment strategy?, Role: Investigator, LLU Dept. of Surgery, (09/2020) Status: Approved
  • A novel combinatorial approach for treating HPV-associated malignancies, Role: PD/PI, LLU School of Medicine, (01/2015 - 09/2017) Status: Closed
  • Virtual reality laparoscopic simulator, Role: Investigator, LLU Dept. of Surgery, (09/2011) Status: Completed
  • Biomarkers associated with cellular survival in pancreatic cancer, Role: PI, LLU Dept. of Medicine, (07/2008 - 07/2009) Status: Completed
  • "CAAPPD" protocol for surgery resident sign-out, Role: PI, LLU Dept. of Surgery, (06/2008 - 06/2009) Status: Completed
  • LLU Cancer Center biospecimen laboratory - specimens collection protocol, Role: PI, LLU Cancer Institute, (09/2024 - 09/2025) Status: Approved
  • GRASP:Oral SlgA immunoglobulin treatment to prevent gastrointestinal mucositis caused by chemotherapy, Role: Consultant, LLU - GRASP, (01/2025 - 12/2026) Status: Awarded

Non-Profit Organization

  • NSABP-B31 - A randomized trial comparing the safety and efficacy of adriamycin and cyclophosphamide followed by taxol (AC-T) to that of adriamycin and cyclophosphmide followed by taxol plus herceptin (AC-T+HC) in node-positive breast cancer patients who have tumors that overexpress HER2., Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (12/2019 - 12/2020) Status: Completed
  • NSABP-B-38 - A Phase III, adjuvant trial comparing three chemotherapy regiments in women with node-positive breast cancer: docetaxel/doxorubicin/cyclophosphamide (TAC); dose-dense (DD) doxorubicin/cyclophosphamide followed by DD paclitaxel (DD AC P); DD AC followed by DD paclitaxel plus gemcitabine (DD AC PG), Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (11/2015 - 11/2016) Status: Completed
  • NSABP-B-36 - A clinical trial of adjuvant therapy comparing six cycles of 5-fluorouracil, epirubicin and cyclophosphamide (FEC) to four cycles of adriamycin and cyclophosphamide (AC) in patients with node-negative breast cancer, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (08/2015 - 08/2016) Status: Completed
  • American College of Surgeons Oncology Group (ACOSOG) Protocol #Z0011 - A randomized trial of axillary node dissection in women with clinical T1 or T2 N0 M0 breast cancer who have a positive sentinel mode, Role: Investigator, American College of Surgeons Oncology Group, (06/2015 - 06/2016) Status: Completed
  • National Surgical adjuvant breast and bowel project (NSABP) R-04 a clinical trial comparing preoperative radiation therapy and capecitabine with or with out oxaliplatin with preoperative radiation therapy and continuous intravenous infusion of 5-fluorouracil with or without oxaliplatin in the treatment of patients with operable carcinoma of the rectum, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (05/2014 - 05/2015) Status: Completed
  • NSABP - B32 - A randomized, phase III clinical trial to compare sentinel node resection to conventional axillary dissection in clinically node-negative breast cancer patients, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (09/2013 - 09/2014) Status: Completed
  • NSABP P-2 - Study of tamoxifen and raloxifene (STAR) for the prevention of breast cancer, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (06/2012 - 06/2013) Status: Completed
  • NSABP-B30. A three-armed randomized trial to compare adjuvant adriamycin and cyclophosphamide followed by toxotere (AC-T); adriamycin and toxotere (AT); and adriamycin, taxotere, and cyclophosphamide (ATC) in breast cancer patients with positive axillary lymph nodes, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (03/2012 - 03/2013) Status: Completed
  • NSABP-B34 - A clinical trial comparing adjuvant clondronate therapy vs placebo in early-stage breast cancer patients receiving systemic chemotherapy and/or hormonal or no therapy, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (02/2012 - 02/2013) Status: Completed
  • NSABP B-27: A randomized trial comparing preoperative doxorubicin cyclophosphamide to preoperative AC followed by preoperative docetaxel and to preoperative AC followed by postoperative docetaxel in patients with operable carcinoma of the breast, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (03/2010 - 03/2011) Status: Completed
  • NSABP B-28. A Randomized Trial Evaluating the Worth of Paclitaxol (Taxol) Following Doxorubicin (Adriamycin)/Cyclophosphamide in Breast Cancer Patients with Positive Axillary Nodes, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (11/2008 - 11/2009) Status: Completed
  • NSABP PROTOCOL C-09: A phase II clinical trial comparing oxaliplatin, capecitabine and hepatic arterial infusion of floxuridine to oxaliplatin and capecitabine in patients with resected or ablated liver metastases from colorectal cancer, Role: PI, National Surgical Adjuvant Breast & Bowel Project, (11/2008 - 11/2009) Status: Completed
  • NSABP CI-66 (NCCTG N9945) - A Phase II trial evaluating multiple metastasectomy combined with hepatic artery infusion of floxuridine (FUDR) and dexamethasone (DXM), alternating with systemic oxaliplatin (OXAL) and capecitabine (CAPCIT) for colorectal carcinoma metastatic to the liver, Role: Investigator, National Surgical Adjuvant Breast & Bowel Project, (03/2004 - 03/2005) Status: Completed