Scholarly Journals--Published

  • Clerc MM, Detzen L, Vi-Fane B, Kerner AS, Garrec P, Rignon-Bret C, Jakubowicz B, Carra MC, De La Dure-Molla M, Fournier BPJ, Kerner SP. Replacement of missing lateral incisors for patients with cleft lip and palate: A decision-making tree based on a systematic review of the literature. J Prosthet Dent. 2023 Sep 5:S0022-3913(23)00489-4. doi: 10.1016/j.prosdent.2023.07.023. Epub ahead of print. PMID: 37679238. Statement of problem: Cleft lip and palate are the most frequent congenital anomalies of the face and are often linked with lateral incisor agenesis. The therapeutic decision on whether and how to replace the lateral incisors is not straightforward, and a decision-making tree is needed. Purpose: The purpose of this systematic review was to evaluate the available literature reporting on treatments for the replacement of missing lateral incisors in cleft areas. By analyzing the success and survival rates of these treatments, a decision-making tree was developed. Material and methods: The literature search was performed on the PubMed (MEDLINE), Web of Science, Cochrane, EMBASE, Dentistry of Oral and Science Source, and Google Scholar databases and was based on the question: Which treatment for patients with lateral incisor agenesis and cleft lip and palate has a good success rate? Results: Twenty-six articles were included in this systematic review. A meta-analysis was performed on 14 articles (20 case series, 6 case controls). The estimated overall 5-year survival rates were 96.4% for implant-supported prostheses. Conclusions: Different treatment options are available, depending on the clinical situation. If the patient meets the conditions for implant placement, this treatment remains a preferred solution. If the prosthetic space is reduced, orthodontic space closure and composite resin restorations are possible. When these options are not possible, a resin-bonded fixed partial denture is the preferred option. If the teeth adjacent to the edentulous area require extensive restorations, a fixed partial denture may be a suitable alternative. (08/2023) (link)
  • Dupré N, Fournier BPJ, Gondel O, Riou MC, Isaac J, Garrec P, Vi-Fane B, Kribel S, De La Dure-Molla M, Carra MC, Felizardo R, Kerner SP. Reduced bone dimension in patients affected by oligodontia: A retrospective study on maxillary and mandibular CBCT. J Clin Periodontol. 2023 Aug 31. doi: 10.1111/jcpe.13866. Epub ahead of print. PMID: 37653705. Aim: Oligodontia (OD) is a rare developmental condition characterized by the absence of six or more teeth. Dental implant placement may be challenging due to anatomical factors. This study aims to evaluate the alveolar bone dimensions in OD patients compared with controls. Materials and methods: On maxillary and mandibular cone-beam computed tomography (CBCT), bone height and width were measured at every tooth and edentulous site. The distance to the inferior alveolar nerve was also measured. Fifty-three OD patients (40 maxillary and 32 mandibular CBCT) and 82 controls (51 maxillary and 31 mandibular CBCT) were compared using mixed models. Results: Compared with those in OD patients, maxillary permanent teeth and edentulous sites showed significantly higher mean height in control patients (incisive-canine site height: +2.12 mm; edentulous incisive-canine site height: +4.46 mm [p > .001]). For the mandibular permanent teeth, mean height was higher in controls than in OD patients at the incisive-canine (+3.82 mm [p > .001]) and premolar areas (+2.06 mm [p > .001]). Only edentulous incisive-canine sites were significantly different between controls and OD patients (mean: +0.52 mm [p > .001]). Changes in alveolar nerve position were observed in case of molar agenesis. Conclusion: Maxillary and mandibular bone dimensions are reduced in OD patients compared with controls both in sites with permanent teeth and in edentulous areas. (08/2023) (link)
  • Duong LT, Petit S, Kerner S, Clerc MM, Arnoult C, Nowwarote N, Osathanon T, Fournier BPJ, Isaac J, Ferré FC. Role of periosteum during healing of alveolar critical size bone defects in the mandible: a pilot study. Clin Oral Investig. 2023 Aug;27(8):4541-4552. doi: 10.1007/s00784-023-05079-y. Epub 2023 Jun 1. PMID: 37261496. Objectives: Minipigs present advantages for studying oral bone regeneration; however, standardized critical size defects (CSD) for alveolar bone have not been validated yet. The objectives of this study are to develop a CSD in the mandibular alveolar bone in Aachen minipigs and to further investigate the specific role of periosteum. Materials and methods: Three female Aachen minipigs aged 17, 24, and 84 months were used. For each minipig, a split-mouth design was performed: an osteotomy (2 cm height × 2.5 cm length) was performed; the periosteum was preserved on the left side and removed on the right side. Macroscopic, cone beam computed tomography (CBCT), microcomputed tomography (µCT), and histological analyses were performed to evaluate the bone defects and bone healing. Results: In both groups, spontaneous healing was insufficient to restore initial bone volume. The macroscopic pictures and the CBCT results showed a larger bone defect without periosteum. µCT results revealed that BMD, BV/TV, and Tb.Th were significantly lower without periosteum. The histological analyses showed (i) an increased osteoid apposition in the crestal area when periosteum was removed and (ii) an ossification process in the mandibular canal area in response to the surgical that seemed to increase when periosteum was removed. Conclusions: A robust model of CSD model was developed in the alveolar bone of minipigs that mimics human mandibular bone defects. This model allows to further investigate the bone healing process and potential factors impacting healing such as periosteum. Clinical relevance: This model may be relevant for testing different bone reconstruction strategies for preclinical investigations. (06/2023) (link)
  • Saade Y, de la Dure Molla M, Fournier BPJ, Kerner S, Colon P, Carra MC, Bouchard P. The dental triage method at Rothschild Hospital during the first lockdown due to the COVID-19 pandemic. PLoS One. 2023 Feb 8;18(2):e0281390. doi: 10.1371/journal.pone.0281390. PMID: 36753528; PMCID: PMC9907804. Objective: This study aims to (1) assess the efficacy of a face-to-face emergency protocol in children and adults and (2) measure the efficacies of prediagnosis at the triage level and clinical diagnosis at the emergency department level during the COVID-19 pandemic. Methods: A triage protocol was applied for patients at the entry of the Rothschild Hospital (AP-HP) between March 18th and May 11th, 2020. First, patients underwent a triage based on self-reported symptoms. If their condition was deemed urgent, they were oriented toward dental professionals, who performed an intraoral examination leading to a clinical diagnosis. Triage and diagnoses were categorized into four emergency groups: infectious, prosthetic, traumatic, and others. The agreement between triage and clinical diagnosis was tested (χ2 test). Positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity for each diagnostic category were assessed to evaluate the performance and efficacy of the triage. Results: Out of 1562 dental visits, 1064 were included in this analysis. The most frequently reported symptoms by children at triage were pain (31.5%) and trauma (22%). Adults mainly complained of abscesses (45.1%) and pulpitis (20.5%). The most frequent clinical diagnoses were abscesses (29.2%) and pulpitis (20.5%) among children and adults, respectively. Tooth extraction was the most frequent treatment modality. Systemic antibiotics were prescribed for 49.2% of patients. Regardless of the age class, the PPV was high for groups 1 to 3, ranging from 78.9% to 100%. The NPV was high in all groups, ranging from 68.8% to 99.1%. Conclusion: This study demonstrates that the triage implanted during the first COVID-19 lockdown was effective and is an appropriate tool for the referral of adults and children before clinical examination.   (02/2023) (link)
  • Riou MC, de La Dure-Molla M, Kerner S, Rondeau S, Legendre A, Cormier-Daire V, Fournier BPJ. Oral phenotype of Singleton-Merten syndrome : a systematic review illustrated with a case report. Front Genet . 2022 Jun 9;13:875490. doi: 10.3389/fgene.2022.875490. eCollection 2022. Background: Singleton-Merten syndrome type 1 (SGMRT1) is a rare autosomal dominant disorder caused by IFIH1 variations with blood vessel calcifications, teeth anomalies, and bone defects. Aim: We aimed to summarize the oral findings in SGMRT1 through a systematic review of the literature and to describe the phenotype of a 10-year-old patient with SGMRT1 diagnosis. Results: A total of 20 patients were described in the literature, in nine articles. Eight IFIH1 mutations were described in 11 families. Delayed eruption, short roots, and premature loss of permanent teeth were the most described features (100%). Impacted teeth (89%) and carious lesions (67%) were also described. Our patient, a 10-year-old male with Singleton-Merten syndrome, presented numerous carious lesions, severe teeth malposition, especially in the anterior arch, and an oral hygiene deficiency with a 100% plaque index. The panoramic X-ray did not show any dental agenesis but revealed very short roots and a decrease in the jaw alveolar bone height. The whole-genome sequencing analysis revealed a heterozygous de novo variant in IFIH1 (NM_022168.4) c.2465G > A (p.Arg822Gln). Conclusion: Confused descriptions of oral features occurred in the literature between congenital findings and "acquired" pathology, especially carious lesions. The dental phenotype of these patients encompasses eruption anomalies (delayed eruption and impacted teeth) and lack of root edification, leading to premature loss of permanent teeth, and it may contribute to the diagnosis. An early diagnosis is essential to prevent teeth loss and to improve the quality of life of these patients. (07/2022) (link)
  • Kerner S, Garabetyan J, Le Roch S, Damman D, Bouchard P. Image distortion of intra-oral photographs: The root coverage model. J Clin Periodontol. 2020;47(7):875-882. (07/2020) (link)
  • Quandalle C, Boillot A, Fournier BP, Garrec P, De La Dure Molla M, Kerner S.  Gingival inflammation, enamel defects, and tooth sensitivity in children with amelogenesis imperfecta: a case-control study. J. Appl. Oral Sci. vol.28  Bauru  2020  Epub Sep 28, 2020. doi: 10.1590/1678-7757-2020-0170. eCollection 2020.  (07/2020) (link)
  • Garabetyan J, Malet J, Kerner S, Detzen L, Carra Mc, Bouchard P. The relationship between dental implant papilla and dental implant mucosa around single-tooth implant in the esthetic area: A retrospective study. Clin Oral Implants Res. 2019 30(12):1229-1237.         (12/2019) (link)
  • Fournier BP, Bruneau MH, Toupenay S, Kerner S, Berdal A, Cormier-Daire V, Hadj-Rabia S, Coudert AE, De La Dure-Molla M. Patterns of Dental Agenesis Highlight the Nature of the Causative Mutated Genes. J Dent Res. 2018 Nov;97(12):1306-1316. (11/2019) (link)
  • Le Roch S, Rouche F, Valet F, Bouchard P; ESCAPE group (including Kerner S). European survey on criteria of aesthetics for periodontal evaluation: The ESCAPE study. J Clin Periodontol. 2019 ;46(11):1116-1123. (11/2019) (link)
  • de La Dure-Molla M, Fournier BP, Manzanares MC, Acevedo AC, Hennekam RC, Friedlander L, Boy-Lefèvre ML, Kerner S, Toupenay S, Garrec P, Vi-Fane B, Felizardo R, Berteretche MV, Jordan L, Ferré F, Clauss F, Jung S, de Chalendar M, Troester S, Kawczynski M, Chaloyard J; International Group of Dental Nomenclature, Manière MC, Berdal A, Bloch-Zupan A. Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders. Am J Med Genet A. 2019 Oct;179(10):1913-1981. doi: 10.1002/ajmg.a.61316. Epub 2019 Aug 29. (10/2019) (link)
  • Jordan L, Beydon N, Razanamihaja N, et al. (including KERNER S)  Translation and cross-cultural validation of the French version of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire. Sleep Med. 2019;58:123-129. (03/2019) (link)
  • Kerner S, Bronnec F. Conservative treatment of a large mid-root perforation. Case Rep Dent. 2015; 2015: 326302. Epub 2015 Mar 9. (03/2015) (link)
  • Davido N, Rigolet A, Kerner S, Gruffaz F, Boucher Y. Case of Ewing's Sarcoma Misdiagnosed as a Periapical Lesion of Maxillary Incisor. J Endod. 2011 ; 37(2):259-64. (02/2011) (link)
  • Kerner S, Migonney V, Pavon-Djavid G, Helary G, Sedel L, Anagnostou F.  Bone tissue response to titanium implant surfaces modified with carboxylate and sulfonate groups. J Mater Sci Mater Med. 2010;21(2):707-15. (02/2010)
  • Kerner S, Katsahian S, Sarfati A, Korngold S, Jakmakjian S, Tavernier B, Valet F, Bouchard P. A comparison of methods of aesthetic assessment in root coverage procedures.J Clin Periodontol. 2009 ;36(1) : 80-87. Aim: To evaluate the reliability of professional qualitative scoring methods used in evaluating aesthetic results after root coverage therapy and to evaluate the relationship between subjective and objective measurements. Material and methods: A review panel of seven professional and non-professional, trained and untrained observers used photographic records to assess the overall cosmetic results of 162 root coverage surgical procedures in 133 patients (mean follow-up 17.51+/-17.37 months). Two different methods were used. In the before-after panel scoring system, observers evaluated the difference between preoperative and postoperative views, whereas in the random panel scoring system, observers rated each photograph independently. Results: For both methods, intrarater agreement ranged from substantial to almost perfect for the periodontists. The best interrater agreement was found for trained periodontists using the five-point ordinal scale of the before-after panel scoring system (kappa=0.68). Neither root coverage percentage nor gingival augmentation was correlated to cosmetic assessment. Conclusions: The before-after scoring system is an acceptable and reliable method for professional cosmetic assessment of root coverage therapy. The overall cosmetic evaluation does not appear to be related to the percentage of root coverage. (01/2009) (link)
  • Kerner S, Sarfati A, Katsahian S, Jaumet V, Micheau C, Mora F, Monnet-Corti V, Bouchard P. Qualitative cosmetic evaluation after root-coverage procedures. J Periodontol. 2009 ; 80(1) : 41-47. (01/2009) (link)
  • Kerner S, Borghetti A, Katsahian S, Etienne D, Malet J, Mora F, Monnet-Corti V, Glise Jm, Bouchard P. A retrospective study of root coverage procedures using an image analysis system. J Clin Periodontol. 2008 ;35(4):346-55. (04/2008) (link)
  • Kerner S, Etienne D, Malet J, Mora F, Monnet-Corti V, Bouchard P.  Root coverage assessment: validity and reproducibility of an image analysis system.  J Clin Periodontol. 2007 ;34(11):969-76. (11/2007) (link)

Online Publications

  • Nham K, Toupenay S, Vuong DA, Samee N, Fournier B, Kerner S. Orthodontia-implantology-prosthodontics in rare diseases: the oligodontia example. J Dentofacial Anom Orthod, 17 2 (2014) 204. DOI: (02/2014) (link)