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Xiang-Qun Hu, PhD
Publications
Xiang-Qun Hu, PhD
Research Professor,
Basic Sciences, Pharmacology Division
School of Medicine
Navigation
Publications
Scholarly Journals--Published
Hu XQ, Song R, Dasgupta C, Liu T, Zhang M, Twum-Barimah S, Blood AB, Zhang L.
Rad-mediated inhibition of Ca(V)1.2 channel activity contributes to uterine artery haemodynamic adaptation to pregnancy.
J Physiol. 2024 Dec;602(24):6729-6744. doi: 10.1113/JP287334. Epub 2024 Nov 29. PubMed PMID: 39612361; NIHMSID:NIHMS2037087. (12/2024)
Nelapudi N, Boskind M, Hu XQ, Mallari D, Chan M, Wilson D, Romero M, Albert-Minckler E, Zhang L, Blood AB, Wilson CG, Puglisi JL, Wilson SM.
Long-term hypoxia modulates depolarization activation of BK(Ca) currents in fetal sheep middle cerebral arterial myocytes.
Front Physiol. 2024;15:1479882. doi: 10.3389/fphys.2024.1479882. eCollection 2024. PubMed PMID: 39563935; PubMed Central PMCID: PMC11573761. (11/2024)
Hu XQ, Zhang L.
Role of transient receptor potential channels in the regulation of vascular tone.
Drug Discov Today. 2024 Jun 3;29(7):104051. doi: 10.1016/j.drudis.2024.104051. [Epub ahead of print] Review. PubMed PMID: 38838960. (06/2024)
cct Hu XQ, Song R, Dasgupta C, Blood AB, Zhang L.
TET2 confers a mechanistic link of microRNA-210 and mtROS in hypoxia-suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep.
J Physiol. 2023 Apr;601(8):1501-1514. doi: 10.1113/JP284336. Epub 2023 Mar 15. PubMed PMID: 36856073; PubMed Central PMCID: PMC10106393. (03/2023)
Hu XQ, Zhang L.
Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders.
Antioxidants (Basel). 2022 Dec 9;11(12). doi: 10.3390/antiox11122432. Review. PubMed PMID: 36552639; PubMed Central PMCID: PMC9774363. (01/2023)
Hu XQ, Zhang L.
Ca2+-Activated K+ Channels and the Regulation of the Uteroplacental Circulation.
Int J Mol Sci. 2023 Jan 10;24(2). doi: 10.3390/ijms24021349. Review. PubMed PMID: 36674858. (01/2023)
Hu XQ, Song R, Dasgupta C, Romero M, Juarez R, Hanson J, Blood AB, Wilson SM, Zhang L.
MicroRNA-210-mediated mtROS confer hypoxia-induced suppression of STOCs in ovine uterine arteries.
Br J Pharmacol. 2022 Oct;179(19):4640-4654. doi: 10.1111/bph.15914. Epub 2022 Jul 17. PMID: 35776536 PMCID:
PMC9474621
(07/2022)
Hu XQ, Zhang L.
Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia.
Curr Hypertens Rep. 2022 Jun;24(6):157-172. doi: 10.1007/s11906-022-01184-7. Epub 2022 Mar 7. Review. PubMed PMID: 35254588. (07/2022)
Hu XQ, Zhang L.
Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development.
Drug Discov Today. 2021 Nov;26(11):2754-2773. doi: 10.1016/j.drudis.2021.07.011. Epub 2021 Jul 22. Review. PubMed PMID: 34302972; PubMed Central PMCID: PMC8612951. (07/2022)
Hu X, Zhang L.
Uteroplacental Circulation in Normal Pregnancy and Preeclampsia: Functional Adaptation and Maladaptation.
Int J Mol Sci. 2021 Aug 11;22(16). doi: 10.3390/ijms22168622. Review. PubMed PMID: 34445328; PubMed Central PMCID: PMC8395300. (07/2022)
Hu XQ, Dasgupta C, Song R, Romero M, Wilson SM, Zhang L.
MicroRNA-210 Mediates Hypoxia-Induced Repression of Spontaneous Transient Outward Currents in Sheep Uterine Arteries During Gestation.
Hypertension. 2021 Apr;77(4):1412-1427. doi: 10.1161/HYPERTENSIONAHA.120.16831. Epub 2021 Mar 1. PubMed PMID: 33641365; PubMed Central PMCID: PMC7946727. (07/2022)
Hu XQ, Zhang L.
MicroRNAs in Uteroplacental Vascular Dysfunction.
Cells. 2019 Oct 29;8(11). doi: 10.3390/cells8111344. (05/2021)
Song R, Hu XQ, Zhang L.
Mitochondrial MiRNA in Cardiovascular Function and Disease.
Cells. 2019 Nov 21;8(12). doi: 10.3390/cells8121475. (05/2021)
Hu XQ, Song R, Romero M, Dasgupta C, Min J, Hatcher D, Xiao D, Blood A, Wilson SM, Zhang L.
Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca2+ Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress.
Hypertension. 2020 Sep;76(3):930-942. (05/2021)
Song R, Hu XQ, Romero M, Holguin MA, Kagabo W, Xiao D, Wilson SM, Zhang L.
Ryanodine receptor subtypes regulate Ca2+ sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy.
Cardiovasc Res. 2021 Feb 22;117(3):792-804. (05/2021)
Hu XQ, Dasgupta C, Song R, Romero M, Wilson SM, Zhang L.
MicroRNA-210 Mediates Hypoxia-Induced Repression of Spontaneous Transient Outward Currents in Sheep Uterine Arteries During Gestation.
Hypertension. 2021 Apr;77(4):1412-1427. (05/2021)
Hu XQ, Zhang L.
Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications.
Antioxidants (Basel). 2021 Mar 8;10(3). doi: 10.3390/antiox10030405. (05/2021)