Publications

Scholarly Journals--Published

• Hu XQ, Song R, Dasgupta C, Liu T, Zhang M, MataGreenwood E, Goulopoulou S, Blood AB, Zhang L. MicroRNA-210-mediated mitochondrial reactive oxygen species contribute to Ca(V)1.2 channel hyperactivity in uterine arteries of pregnant sheep acclimatized to high-altitude hypoxia. J Physiol. 2026 Apr 11;. doi: 10.1113/JP290989. [Epub ahead of print] PubMed PMID: 41965320. (04/2026)
• Hu XQ, Song R, Dasgupta C, Twum-Barimah S, Wang C, Kremsky I, Blood AB, Zhang L. Chronic hypoxia during gestation impairs Rad-mediated inhibition of Ca(V)1.2 channel and increases uterine vascular resistance in pregnant sheep. J Physiol. 2026 Mar;604(5):2212-2228. doi: 10.1113/JP290638. Epub 2026 Jan 31. PubMed PMID: 41620385. (03/2026)
• Hu XQ, Song R, Dasgupta C, Blood AB, Zhang L. Fetal Hypoxia Suppresses TRPC6 and Impairs Cerebral Autoregulation in Neonatal Rats. Stroke. 2025 Sep 17;. doi: 10.1161/STROKEAHA.125.052524. [Epub ahead of print] PubMed PMID: 40959868. (09/2025)
• Hu XQ, Dasgupta C, Gao Y, Kremsky I, Mata-Greenwood E, Zhang L. The uteroplacental circulation at high altitude: adaptation and maladaptation. Philos Trans R Soc Lond B Biol Sci. 2025 Aug 21;380(1933):20240179. doi: 10.1098/rstb.2024.0179. Epub 2025 Aug 21. Review. PubMed PMID: 40836808; PubMed Central PMCID: PMC12368551. (08/2025)
• Hu XQ, Song R, Dasgupta C, Twum-Barimah S, Liu T, Ahmed A, Hanson SF, Zhang L, Blood AB. MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb. Hypertension. 2025 Jun;82(6):1151-1163. doi: 10.1161/HYPERTENSIONAHA.124.23061. Epub 2025 Apr 23. PubMed PMID: 40265266; PubMed Central PMCID: PMC12077996. (05/2025)
• Hu XQ, Song R, Dasgupta C, Liu T, Zhang M, Twum-Barimah S, Blood AB, Zhang L. Rad-mediated inhibition of Ca(V)1.2 channel activity contributes to uterine artery haemodynamic adaptation to pregnancy. J Physiol. 2024 Dec;602(24):6729-6744. doi: 10.1113/JP287334. Epub 2024 Nov 29. PubMed PMID: 39612361; NIHMSID:NIHMS2037087. (12/2024)
• Nelapudi N, Boskind M, Hu XQ, Mallari D, Chan M, Wilson D, Romero M, Albert-Minckler E, Zhang L, Blood AB, Wilson CG, Puglisi JL, Wilson SM. Long-term hypoxia modulates depolarization activation of BK(Ca) currents in fetal sheep middle cerebral arterial myocytes. Front Physiol. 2024;15:1479882. doi: 10.3389/fphys.2024.1479882. eCollection 2024. PubMed PMID: 39563935; PubMed Central PMCID: PMC11573761. (11/2024)
• Hu XQ, Zhang L. Role of transient receptor potential channels in the regulation of vascular tone. Drug Discov Today. 2024 Jun 3;29(7):104051. doi: 10.1016/j.drudis.2024.104051. [Epub ahead of print] Review. PubMed PMID: 38838960. (06/2024)
• cct Hu XQ, Song R, Dasgupta C, Blood AB, Zhang L. TET2 confers a mechanistic link of microRNA-210 and mtROS in hypoxia-suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep. J Physiol. 2023 Apr;601(8):1501-1514. doi: 10.1113/JP284336. Epub 2023 Mar 15. PubMed PMID: 36856073; PubMed Central PMCID: PMC10106393. (03/2023)
• Hu XQ, Zhang L. Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders. Antioxidants (Basel). 2022 Dec 9;11(12). doi: 10.3390/antiox11122432. Review. PubMed PMID: 36552639; PubMed Central PMCID: PMC9774363. (01/2023)
• Hu XQ, Zhang L. Ca2+-Activated K+ Channels and the Regulation of the Uteroplacental Circulation. Int J Mol Sci. 2023 Jan 10;24(2). doi: 10.3390/ijms24021349. Review. PubMed PMID: 36674858. (01/2023)
• Hu XQ, Song R, Dasgupta C, Romero M, Juarez R, Hanson J, Blood AB, Wilson SM, Zhang L. MicroRNA-210-mediated mtROS confer hypoxia-induced suppression of STOCs in ovine uterine arteries. Br J Pharmacol. 2022 Oct;179(19):4640-4654. doi: 10.1111/bph.15914. Epub 2022 Jul 17. PMID: 35776536 PMCID: PMC9474621  (07/2022)
• Hu XQ, Zhang L. Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia. Curr Hypertens Rep. 2022 Jun;24(6):157-172. doi: 10.1007/s11906-022-01184-7. Epub 2022 Mar 7. Review. PubMed PMID: 35254588. (07/2022)
• Hu XQ, Zhang L. Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development. Drug Discov Today. 2021 Nov;26(11):2754-2773. doi: 10.1016/j.drudis.2021.07.011. Epub 2021 Jul 22. Review. PubMed PMID: 34302972; PubMed Central PMCID: PMC8612951. (07/2022)
• Hu X, Zhang L. Uteroplacental Circulation in Normal Pregnancy and Preeclampsia: Functional Adaptation and Maladaptation. Int J Mol Sci. 2021 Aug 11;22(16). doi: 10.3390/ijms22168622. Review. PubMed PMID: 34445328; PubMed Central PMCID: PMC8395300. (07/2022)
• Hu XQ, Dasgupta C, Song R, Romero M, Wilson SM, Zhang L. MicroRNA-210 Mediates Hypoxia-Induced Repression of Spontaneous Transient Outward Currents in Sheep Uterine Arteries During Gestation. Hypertension. 2021 Apr;77(4):1412-1427. doi: 10.1161/HYPERTENSIONAHA.120.16831. Epub 2021 Mar 1. PubMed PMID: 33641365; PubMed Central PMCID: PMC7946727. (07/2022)
• Hu XQ, Zhang L. MicroRNAs in Uteroplacental Vascular Dysfunction. Cells. 2019 Oct 29;8(11). doi: 10.3390/cells8111344. (05/2021)
• Song R, Hu XQ, Zhang L. Mitochondrial MiRNA in Cardiovascular Function and Disease. Cells. 2019 Nov 21;8(12). doi: 10.3390/cells8121475. (05/2021)
• Hu XQ, Song R, Romero M, Dasgupta C, Min J, Hatcher D, Xiao D, Blood A, Wilson SM, Zhang L. Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca2+ Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress. Hypertension. 2020 Sep;76(3):930-942. (05/2021)
• Song R, Hu XQ, Romero M, Holguin MA, Kagabo W, Xiao D, Wilson SM, Zhang L. Ryanodine receptor subtypes regulate Ca2+ sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy. Cardiovasc Res. 2021 Feb 22;117(3):792-804. (05/2021)
• Hu XQ, Dasgupta C, Song R, Romero M, Wilson SM, Zhang L. MicroRNA-210 Mediates Hypoxia-Induced Repression of Spontaneous Transient Outward Currents in Sheep Uterine Arteries During Gestation. Hypertension. 2021 Apr;77(4):1412-1427. (05/2021)
• Hu XQ, Zhang L. Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications. Antioxidants (Basel). 2021 Mar 8;10(3). doi: 10.3390/antiox10030405. (05/2021)