• 1. Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats. Yu S, Doycheva DM, Gamdzyk M, Yang Y, Lenahan C, Li G, Li D, Lian L, Tang J, Lu J, Zhang JH.J Neuroinflammation. 2021 Jan 19;18(1):26. doi: 10.1186/s12974-021-02078-2. 2. Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE. Hu X, Li S, Doycheva DM, Huang L, Lenahan C, Liu R, Huang J, Gao L, Tang J, Zuo G, Zhang JH.Oxid Med Cell Longev. 2020 Oct 7;2020:6801587. doi: 10.1155/2020/6801587. eCollection 2020. 3. GW0742 activates miR-17-5p and inhibits TXNIP/NLRP3-mediated inflammation after hypoxic-ischaemic injury in rats and in PC12 cells. Gamdzyk M, Doycheva DM, Kang R, Tang H, Travis ZD, Tang J, Zhang JH. 4. Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE. Hu X, Li S, Doycheva DM, Huang L, Lenahan C, Liu R, Huang J, Xie S, Tang J, Zuo G, Zhang JH.J Neuroinflammation. 2020 Jun 10;17(1):182. doi: 10.1186/s12974-020-01862-w. 5. IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model. Huang J, Lu W, Doycheva DM, Gamdzyk M, Hu X, Liu R, Zhang JH, Tang J. 6. cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1. Gamdzyk M, Doycheva DM, Araujo C, Ocak U, Luo Y, Tang J, Zhang JH. 7. Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model. Doycheva D, Xu N, Kaur H, Malaguit J, McBride DW, Tang J, Zhang JH.Dis Model Mech. 2019 Nov 22;12(11):dmm040352. doi: 10.1242/dmm.040352. 8. Viral-mediated gene delivery of TMBIM6 protects the neonatal brain via disruption of NPR-CYP complex coupled with upregulation of Nrf-2 post-HI. Doycheva D, Xu N, Tang J, Zhang J.J Neuroinflammation. 2019 Aug 31;16(1):174. doi: 10.1186/s12974-019-1559-4. 9. Recombinant Slit2 attenuates neuronal apoptosis via the Robo1-srGAP1 pathway in a rat model of neonatal HIE. Kaur H, Xu N, Doycheva DM, Malaguit J, Tang J, Zhang JH.Neuropharmacology. 2019 Nov 1;158:107727. doi: 10.1016/j.neuropharm.2019.107727. Epub 2019 Jul 26. 10. Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE. Huang J, Liu W, Doycheva DM, Gamdzyk M, Lu W, Tang J, Zhang JH.Free Radic Biol Med. 2019 Sep;141:322-337. doi: 10.1016/j.freeradbiomed.2019.07.001. Epub 2019 Jul 3. 11. RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats. Liu W, Huang J, Doycheva D, Gamdzyk M, Tang J, Zhang JH.Exp Neurol. 2019 Oct;320:112982. doi: 10.1016/j.expneurol.2019.112982. Epub 2019 Jun 24. 12. The characteristics of the ancient cell death suppressor, TMBIM6, and its related signaling pathways after endoplasmic reticulum stress. Doycheva D, Kaur H, Tang J, Zhang JH.J Neurosci Res. 2020 Jan;98(1):77-86. doi: 10.1002/jnr.24434. Epub 2019 May 1. 13. The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage. Desislava Doycheva Page 5/7Chen S, Zuo Y, Huang L, Sherchan P, Zhang J, Yu Z, Peng J, Zhang J, Zhao L, Doycheva D, Liu F, Zhang JH, Xia Y, Tang J.Br J Pharmacol. 2019 May;176(9):1341-1356. doi: 10.1111/bph.14639. Epub 2019 Apr 9. 14. Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy. Zhang Y, Xu N, Ding Y, Doycheva DM, Zhang Y, Li Q, Flores J, Haghighiabyaneh M, Tang J, Zhang JH.Cell Death Dis. 2019 Feb 4;10(2):97. doi: 10.1038/s41419-019-1374-y. 15. Long noncoding RNA AC003092.1 promotes temozolomide chemosensitivity through miR-195/TFPI-2 signaling modulation in glioblastoma. Xu N, Liu B, Lian C, Doycheva DM, Fu Z, Liu Y, Zhou J, He Z, Yang Z, Huang Q, Zeng H, Guo H.Cell Death Dis. 2018 Nov 15;9(12):1139. doi: 10.1038/s41419-018-1183-8. 16. Neurogenesis changes and the fate of progenitor cells after subarachnoid hemorrhage in rats. Zuo Y, Wang J, Enkhjargal B, Doycheva D, Yan X, Zhang JH, Liu F.Exp Neurol. 2019 Jan;311:274-284. doi: 10.1016/j.expneurol.2018.10.011. Epub 2018 Oct 23. 17. Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats. Gamdzyk M, Doycheva DM, Malaguit J, Enkhjargal B, Tang J, Zhang JH.Neuropharmacology. 2018 Sep 15;140:150-161. doi: 10.1016/j.neuropharm.2018.08.003. Epub 2018 Aug 4. 18. Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats. Zhang Y, Xu N, Ding Y, Zhang Y, Li Q, Flores J, Haghighiabyaneh M, Doycheva D, Tang J, Zhang JH. Brain Behav Immun. 2018 May;70:179-193. doi: 10.1016/j.bbi.2018.02.015. Epub 2018 Mar 1. 19. Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats. Xu N, Zhang Y, Doycheva DM, Ding Y, Zhang Y, Tang J, Guo H, Zhang JH. Neuropharmacology. 2018 May 1;133:415-428. doi: 10.1016/j.neuropharm.2018.02.024. Epub 2018 Feb 24. 20. IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. Chen D, Dixon BJ, Doycheva DM, Li B, Zhang Y, Hu Q, He Y, Guo Z, Nowrangi D, Flores J, Filippov V, Zhang JH, Tang J. J Neuroinflammation. 2018 Feb 2;15(1):32. doi: 10.1186/s12974-018-1077-9. 21. CpG-ODN exerts a neuroprotective effect via the TLR9/pAMPK signaling pathway by activation of autophagy in a neonatal HIE rat model. Ye L, Feng Z, Doycheva D, Malaguit J, Dixon B, Xu N, Zhang JH, Tang J. Exp Neurol. 2018 Mar;301(Pt A):70-80. doi: 10.1016/j.expneurol.2017.12.008. Epub 2017 Dec 21. 22. Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats. Shi X, Doycheva DM, Xu L, Tang J, Yan M, Zhang JH. Neurobiol Dis. 2016 Nov;95:111-21. doi: 10.1016/j.nbd.2016.07.016. Epub 2016 Jul 16. 23. Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups. Shi X, Xu L, Doycheva DM, Tang J, Yan M, Zhang JH. J Cereb Blood Flow Metab. 2017 Apr;37(4):1447-1460. doi: 10.1177/0271678X16656201. Epub 2016 Jan 1. 24. Osteopontin-Rac1 on Blood-Brain Barrier Stability Following Rodent Neonatal Hypoxia-Ischemia. Desislava Doycheva Page 6/7Dixon B, Malaguit J, Casel D, Doycheva D, Tang J, Zhang JH, Lekic T. Acta Neurochir Suppl. 2016;121:263-7. doi: 10.1007/978-3-319-18497-5_46. 25. Intranasal Osteopontin for Rodent Germinal Matrix Hemorrhage. Malaguit J, Casel D, Dixon B, Doycheva D, Tang J, Zhang JH, Lekic T. Acta Neurochir Suppl. 2016;121:217-20. doi: 10.1007/978-3-319-18497-5_39. 26. Intranasal IGF-1 Reduced Rat Pup Germinal Matrix Hemorrhage. Lekic T, Flores J, Klebe D, Doycheva D, Rolland WB, Tang J, Zhang JH. Acta Neurochir Suppl. 2016;121:209-12. doi: 10.1007/978-3-319-18497-5_37. 27. Subarachnoid Hemorrhage-Triggered Acute Hypotension Is Associated with Left Ventricular Cardiomyocyte Apoptosis in a Rat Model. Fujii M, Sherchan P, Soejima Y, Doycheva D, Zhang JH. Acta Neurochir Suppl. 2016;121:145-50. doi: 10.1007/978-3-319-18497-5_26. 28. Cannabinoid Receptor Type 2 Agonist Attenuates Acute Neurogenic Pulmonary Edema by Preventing Neutrophil Migration after Subarachnoid Hemorrhage in Rats. Fujii M, Sherchan P, Soejima Y, Doycheva D, Zhao D, Zhang JH. Acta Neurochir Suppl. 2016;121:135-9. doi: 10.1007/978-3-319-18497-5_24. 29. Changes in Brain Swelling and Infarction Volume over Four Days After Hypoxia Ischemia in Neonatal Rats. McBride DW, Jacob C, Doycheva D, Dixon BJ, Malaguit J, Lekic T, Tang J, Zhang JH. Acta Neurochir Suppl. 2016;121:111-4. doi: 10.1007/978-3-319-18497-5_19. 30. Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials. Chen S, Shi L, Liang F, Xu L, Desislava D, Wu Q, Zhang J. Mol Neurobiol. 2016 Aug;53(6):4046-4053. doi: 10.1007/s12035-015-9350-8. Epub 2015 Jul 21. 31. Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model. Charles MS, Drunalini Perera PN, Doycheva DM, Tang J. Exp Neurol. 2015 Oct;272:152-9. doi: 10.1016/j.expneurol.2015.03.019. Epub 2015 Mar 25. 32. Erythropoietin in stroke therapy: friend or foe. Souvenir R, Doycheva D, Zhang JH, Tang J. Curr Med Chem. 2015;22(10):1205-13. Review. 33. G-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats. Li L, McBride DW, Doycheva D, Dixon BJ, Krafft PR, Zhang JH, Tang J. Exp Neurol. 2015 Oct;272:135-44. doi: 10.1016/j.expneurol.2014.12.020. Epub 2015 Jan 10. 34. G-CSF ameliorates neuronal apoptosis through GSK-3β inhibition in neonatal hypoxia-ischemia in rats. Li L, Klebe D, Doycheva D, McBride DW, Krafft PR, Flores J, Zhou C, Zhang JH, Tang J. Exp Neurol. 2015 Jan;263:141-9. doi: 10.1016/j.expneurol.2014.10.004. Epub 2014 Oct 18. 35. Abrogation of cerebral edema and vascular inflammation following subarachnoid hemorrhage by cannabinoid receptor activation. Fujii M, Sherchan P, Soejima Y, Hasegawa Y, Flores J, Doycheva D, Zhang JH. J Neurol Sci. 2014 Nov 15;346(1-2):338. doi: 10.1016/j.jns.2014.08.015. Epub 2014 Aug 19. No abstract available. 36. Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid hemorrhage in rats. Fujii M, Sherchan P, Soejima Y, Hasegawa Y, Flores J, Doycheva D, Zhang JH. Exp Neurol. 2014 Nov;261:396-403. doi: 10.1016/j.expneurol.2014.07.005. Epub 2014 Jul 22. Desislava Doycheva Page 7/7 37. Anti-neutrophil antibody enhances the neuroprotective effects of G-CSF by decreasing number of neutrophils in hypoxic ischemic neonatal rat model. Doycheva DM, Hadley T, Li L, Applegate RL 2nd, Zhang JH, Tang J. Neurobiol Dis. 2014 Sep;69:192-9. doi: 10.1016/j.nbd.2014.05.024. Epub 2014 May 27. 38. Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1α/β-catenin pathway in middle cerebral artery occlusion rats. Hu Q, Liang X, Chen D, Chen Y, Doycheva D, Tang J, Tang J, Zhang JH. Stroke. 2014 Jun;45(6):1807-14. doi: 10.1161/STROKEAHA.114.005116. Epub 2014 Apr 22. 39. Delayed remote ischemic postconditioning improves long term sensory motor deficits in a neonatal hypoxic ischemic rat model. Drunalini Perera PN, Hu Q, Tang J, Li L, Barnhart M, Doycheva DM, Zhang JH, Tang J. PLoS One. 2014 Feb 28;9(2):e90258. doi: 10.1371/journal.pone.0090258. eCollection 2014. 40. Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment. Doycheva D, Shih G, Chen H, Applegate R, Zhang JH, Tang J. Transl Stroke Res. 2013 Apr;4(2):171-8. doi: 10.1007/s12975-012-0225-2. Epub 2012 Nov 8. (06/2021)