Research Projects & Grants

College/University

• A randomized clinical trial of therapeutic hypothermia during transport for Hypoxic Ischemic Encephalopathy (HIE): device-regulated cooling versus standard practice, Role: Investigator, Stanford University, (09/2013 - 09/2014) Status: Completed

Federal

• Pain and hypoxia in premature neonates, Role: Investigator, National Institutes of Health/DHHS, (06/2024 - 06/2025) Status: Approved
• Premature infants receiving milking or delayed cord clamping: Randomized controlled multicenter non-inferiority trial, Role: Investigator, National Institute of Child Health and Human Development/NIH/DHHS, (12/2024 - 12/2025) Status: Approved
• Non pharmacological interventions for procedural pain in preterm neonates, Role: Other Significant Contributor, National Institute of Nursing Research/NIH/DHHS, (09/2014 - 07/2019) Status: Closed
• Systemic Hypotension following pediatric surgical procedures including patent ductus arteriosus ligation: the role of adrenal immaturity, Role: Investigator, National Heart, Lung, and Blood Institute/NIH/DHHS, (02/2012 - 02/2013) Status: Completed
• Pain and Hypoxia in Premature Neonates, Role: Consultant, National Institute of Nursing Research/NIH/DHHS, (07/2009 - 04/2014) Status: Closed
• Pharmacokinetics of L-arginine in premature infants, Role: Co-investigator, National Medical Technology Testbed, Inc., (02/2009 - 03/2011) Status: Closed
• Inhaled nitric oxide for the prevention of chronic lung disease in premature newborns, Role: Investigator, National Institutes of Health/DHHS, (06/2008 - 06/2009) Status: Completed

For Profit Organization

• A multicenter, randomized, open-label, controlled trial to assess the safety and tolerability of lucinactant for inhalation in preterm neonates 29 to 34 weeks PMA: dose escalation and study extension, Role: Investigator, Discovery Laboratories, Inc., (12/2015 - 12/2016) Status: Completed
• An open label, multicenter, phase 2, pilot evaluation of surfaxin (lucinactant) delivered as an aerosol via nasal continuous positive airway pressure (NCPAP) in the prevention of respiratory distress syndrome in premature infants, Role: Investigator, Discovery Laboratories, Inc., (01/2006 - 01/2007) Status: Completed
• KL4-BPD-01 A randomized, double-blind, placebo-controlled trials to assess the safety and efficacy of surfaxin® (lucinactant), in very low birth weight (VLBW) infants at risk for developing bronchopulmonary dysplasia. IND # 40,287, Role: Investigator, Discovery Laboratories, Inc., (08/2005 - 08/2006) Status: Completed

Foreign

• Safeguarding the brain of our smallest children - An investigator-initiated, pragmatic, open-label, multinational randomized phase III clinical trial evaluating treatment based on near-infrared spectroscopy monitoring versus treatment as usual in premature infants, Role: Investigator, Region Hovedstaden, (08/2021 - 08/2022) Status: Completed

Internal

• Oxidative stress, DNA methylation, gene endothelial biology, and gene expression in the human placenta, Role: Investigator, LLU Dept. of Gynecology & Obstetrics, (08/2024 - 08/2025) Status: Approved
• aEEG screening of neonates with congenital heart disease (CHD), Role: Investigator, LLU Dept. of Pediatrics, (07/2024 - 07/2025) Status: Approved
• Non-pharmacological interventions for procedural pain in premature neonates, Role: Investigator, LLU Basic Science, (04/2025 - 04/2026) Status: Approved
• Quantification of hypoxanthine, xanthine, uric acid, allantoin, and creatinine in neonates, Role: Investigator, LLU School of Medicine, (06/2024 - 06/2025) Status: Approved
• Characterization of vitamin D status and metabolism in preeclampsia, Role: Investigator, LLU Dept. of Gynecology & Obstetrics, (02/2025 - 02/2026) Status: Approved
• Outcomes of various therapy types for the patent ductus arteriosus in preterm infants, Role: Investigator, LLU Dept. of Pediatrics, (12/2024 - 12/2025) Status: Approved
• Early detection of necrotizing enterocolitis in infants with perinatal intestinal injury, Role: Investigator, LLU Dept. of Surgery, (12/2024 - 12/2025) Status: Approved
• Pain and stress in premature infants, Role: Investigator, LLU Basic Science, (12/2024 - 12/2025) Status: Approved
• Adaptive dynamic inspiratory nasal apparatus(ADINA): comparison to high flow nasal cannula (HFNC), Role: Investigator, LLU Dept. of Pediatrics, (10/2024 - 10/2025) Status: Approved
• Effects of extracorporeal membrane oxygenation on intra-abdominal pressure and acute kidney injury, Role: Investigator, LLU Dept. of Pediatrics, (10/2020 - 10/2021) Status: Completed
• Impact of spiritual care by medical personnel in a Neonatal Intensive Care Unit, Role: Investigator, LLU Dept. of Pediatrics, (06/2020 - 04/2024) Status: Completed
• Estimation of gestational age via smartphone ophthalmoscope assessment of anterior lens capsule vascularity in preterm infants, Role: Investigator, LLU Dept. of Pediatrics, (07/2019 - 07/2020) Status: Completed
• Music for mothers in the NICU: The effect of psycho-acoustically designed music on stress reduction in babies and their mothers in the neonatal intensive care unit (NICU), Role: Investigator, LLU Dept. of Pediatrics, (01/2018 - 01/2019) Status: Completed
• The association of kangaroo mother care, energy conservation, and bonding in preterm neonates, Role: PI, LLU Basic Science, (05/2017 - 05/2018) Status: Completed
• Effects of intrapartum analgesic medications on newborn behaviors while skin to skin with mother in the first hours after birth: A pilot study, Role: Investigator, LLU Dept. of Pediatrics, (05/2014 - 05/2015) Status: Completed
• Novel adaptive inspiratory nasal apparatus (ADINA): Comparison to high flow nasal cannula simulating traditional nasal continuous positive airway pressure (NCPAP), Role: Investigator, LLU Dept. of Pediatrics, (03/2014 - 03/2015) Status: Completed
• Effect of extracorporeal membrane oxygenation on ventricular size, Role: Investigator, LLU Dept. of Radiology, (08/2013 - 08/2014) Status: Completed
• Utility of amplitude integrated EEG in identifying infants with electrographic seizures predicting abnormal brain imaging and mortality, Role: Investigator, LLU Dept. of Pediatrics, (07/2013 - 07/2014) Status: Completed
• Plasma, urine, stool, gastric residual and saliva nitrite concentrations in preterm infants with NEC, Role: Investigator, LLU Dept. of Pediatrics, (01/2012 - 01/2013) Status: Completed
• Pulmonary hypertension in premature very low birth weight infants, Role: Investigator, LLU Dept. of Pediatrics, (08/2009 - 08/2010) Status: Completed
• A novel method to monitor oxygen management and its effect in the reduction of retinopathy of prematurity, Role: PI, LLU Dept. of Pediatrics, (04/2009) Status: Completed
• Residual-Neonatal Research Laboratory, Role: Principal Investigator, LLU Dept. of Pediatrics, (02/2007 - 06/2011) Status: Closed
• Retrospective chart review of low birth weight infants who have prostin-dependent congenital cardiac disease, Role: Investigator, LLU Dept. of Pediatrics, (11/2006) Status: Completed
• Anemia and the risk of necrotizing enterocolitis, Role: PI, LLU Dept. of Pediatrics, (06/2006 - 06/2007) Status: Completed
• Gastroschisis: small defect, big mystery. A restrospective review of the temporal and geographical trends in the prevalence of gastroschisis in a 5-county region in Southern California, Role: Investigator, LLU Dept. of Pediatrics, (06/2005 - 06/2006) Status: Completed
• Low thyroxine levels in transient hypothyproxmenia-real or artifactual?, Role: Investigator, LLU Dept. of Pediatrics, (09/2000 - 09/2001) Status: Completed
• Use of cisapride in neonates and its effect on QTc, Role: Investigator, LLU Dept. of Pediatrics, (02/1999 - 02/2000) Status: Completed
• Comparison of traditional vs higher dose iron supplementation in premature infants undergoing treatment with recombinant human erythropoietin, Role: Investigator, LLU Dept. of Pediatrics, (02/1998 - 02/1999) Status: Completed
• Pre-operative lung ultrasound score and its association with post-operative outcomes in infants with congenital cardiac defect, Role: Investigator, LLU Dept. of Pediatrics, (01/2025) Status: Approved