Publications

Scholarly Journals--Accepted

• Pentecost AM, Boskovic DS, Antimo A, Oyoyo U, Perry CC, Dunbar J, Hopper A, Angeles DM. Energy Utilization in Premature Neonates Undergoing Screening for Retinopathy of Prematurity. Pediatr Rep. 2025 Mar 3;17(2):29. doi: 10.3390/pediatric17020029. PMID: 40126228; PMCID: PMC11932259 (03/2025)
• Brashear N, D'Errico E, Truax FN, Pentecost A, Tan JBC, Bahjri K, Angeles D. Physiological Effects of Handling in Moderate to Late Preterm Infants Receiving Neonatal Intensive Care. Adv Neonatal Care. 2023 Feb 6. doi: 10.1097/ANC.0000000000001055. Epub ahead of print. PMID: 36744892. (02/2023)
• Esiaba I, Angeles DM,Milford T, Salto L, Payne KJ, Kidder M, Boskovic DS.  Preterm premature rupture of membrane or respiratory distress is associated with reduced platelet-neutrophil interactions in the cord blood of preterm newborns.  Accepted for publication, Neonatology, 2018. (10/2018)

Abstract

• Poster E-Walk oral presentation: Impact of procedural pain on mesenteric tissue oxygen saturation in preterm neonates.ESPNIC, Athens, Greece. June 2023 Purpose: Premature neonates experience up to 14 tissue-damaging procedures (TDPs) per day while hospitalized in the neonatal intensive care unit (NICU) [1]. We previously published that (TDPs) such as tape removal increase plasma markers of hypoxia [2]. However, the impact of TDPs on the oxygenation of specific organ systems was not yet understood. Because the most common TDP performed in the NICU is a heel lance [3], we examined the effect of this TDP on mesenteric tissue oxygenation (mStO2). Methods: Mesenteric oxygen saturation (StO2) was measured in eight premature neonates before and during a clinically required heel lance, and up to three minutes from the end of heel lance, using near infrared spectroscopy (NIRS)[4]. Average percent change and maximum percent desaturation in mStO2 during heel lance was calculated. Neonatal pain was scored at baseline and during procedural heel lance using the Premature Infant Pain Profile-Revised (PIPP-R) [1]. Subjects were provided non- pharmacologic pain support (facilitated tucking or 30% dextrose) to reduce signs of pain. Results: Mean (SD) percent change in mStO2 for neonates tested was - 4.2% (10.1) during and three minutes after heel lance. The average minimum and maximum percent change during that period was 12.1% and -19.5%, respectively. However, individual neonates experienced maximum (SD) percent reduction in mStO2 of -9.0% (14.9) with a minimum and maximum of -13.4% and -28.6%. Gestational age correlated significantly with the mean percent change in mStO2 (Pearson correlation: 0.738, P = 0.037), suggesting that larger reductions in mStO2 during heel lance are associated with lower gestation or greater prematurity. More importantly, a significant negative correlation between procedural pain score and maximum percent reduction in mStO2 is observed (Pearson correlation: -0.901, P = 0.037), indicating that the higher the pain score the larger the mesenteric oxygen desaturation. Conclusion: Neonates experiencing a single heel lance undergo a reduction in mesenteric StO2. The impact of such mStO2reductions on organ functions are not currently known, either singly or following repeated instances. Because preterm neonates are at risk for gastrointestinal disorders, such as necrotizing enterocolitis, appropriately powered studies are needed to investigate this further. (06/2023) (link)

Scholarly Journals--Published

• Angeles DM, Boskovic DS, Tan JC, Shih W, Hoch E, Forde D, Phillips RM, Hopper A, Deming DD, Goldstein M, Truong G, Febre A, Pegis P, Lavery A, Kadri M, Banerji A, Mousselli I, Farha V, Fayard E. Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial. J Perinatol. 2020 Jun;40(6):888-895. doi: 10.1038/s41372-020-0634-0. Epub 2020 Feb 26. PMID: 32103160; PMCID: PMC7253349 (06/2020)
• Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial. Angeles DM, Boskovic DS, Tan JC, Shih W, Hoch E, Forde D, Phillips RM, Hopper A, Deming DD, Goldstein M, Truong G, Febre A, Pegis P, Lavery A, Kadri M, Banerji A, Mousselli I, Farha V, Fayard E.J Perinatol. 2020 Jun;40(6):888-895. doi: 10.1038/s41372-020-0634-0. Epub 2020 Feb 2 (02/2020) (link)
• Forde D, Deming DD, Tan JC, Phillips RM, Fry-Bowers EK, Barger MK, Bahjri K, Angeles DM, Boskovic DS. Oxidative Stress Biomarker Decreased in Preterm Neonates Treated with Kangaroo Mother Care. Biol Res Nurs. 2020 Apr;22(2):188-196. doi: 10.1177/1099800419900231. Epub 2020 Jan 24. PMID: 31973579; PMCID: PMC7273802 (01/2020)
• Esiaba I, Angeles DM, Milford T, Salto L, Payne KJ, Kidder M, Boskovic DS.Platelet-neutrophil interactions are lower in the cord blood of premature neonates. Neonatology. 2018 Nov 27;115(2):149-155. doi: 10.1159/000494103 (11/2018)
• Tan, JC, Boskovic DS, Angeles DM.The energy costs of prematurity and the NICU experience.  Antioxidants (Basel). 2018 Mar 2; 7(4). Pii: E37. doi: 10.3390/antiox7030037. Review. PubMed PMID: 29498645; PubMed Central PMCID: PMC5874523 (05/2018)
• Hyung N, Campwala I, Boskovic DS, Slater L, Asmerom Y, Holden MS, Angeles DM, Gollin G. The relationship of red blood cell transfusion to intestinal mucosal injury in premature infants. J Pediatr Surg. 2017 Jul;52(7):1152-1155 (07/2017)
• Angeles DM, Asmerom Y, Boskovic DS, Slater L, Bacot-Carter S, Bahjri K, Mukasa J, Holden M, Fayard E. Oral sucrose for heel lance enhances adenosine triphosphate use in preterm neonates with respiratory distress. SAGE Open Med. 2015 Oct 28;3:2050312115611431. doi: 10.1177/2050312115611431. eCollection 2015. (10/2015)
• Esiaba I, Angeles D M, Holden M S, Tan J B, Asmerom Y, Gollin G, & Boskovic D S. (2015). Urinary Allantoin Is Elevated in Severe Intraventricular Hemorrhage in the Preterm Newborn. Transl Stroke Res, , . (05/2015)
• Holden M S, Hopper A, Slater L, Asmerom Y, Esiaba I, Boskovic D S, & Angeles D M. (2014). Urinary hypoxanthine as a measure of increased ATP utilization in late preterm infants. ICAN: Infant, Child & Adolescent Nutrition, 6(4), 240-249. (2014)
• Gollin Gerald, Stadie Derek, Mayhew Jon, Slater Laurel, Asmerom Yayesh, . . . Angeles Danilyn. (2014). Early Detection of Impending Necrotizing Enterocolitis with Urinary Intestinal Fatty Acid-Binding Protein. Neonatology (16617800), 106(3), 195-200. (2014)
• Plank M S, Boskovic D S, Tagge E, Chrisler J, Slater L, Angeles K R, & Angeles D M. (2011). An Animal Model for Measuring the Effect of Common NICU Procedures on ATP Metabolism. Biological Research for Nursing, 13(3), 283-288. (07/2011)
• Mannoia K, Boskovic D S, Slater L, Plank M S, Angeles D M, & Gollin G. (2011). Necrotizing enterocolitis is associated with neonatal intestinal injury. Journal of Pediatric Surgery, 46(1), 81-85. (01/2011)
• Plank M S, Calderon T C, Asmerom Y, Boskovic D S, & Angeles D M. (2011). Biochemical measurement of neonatal hypoxia. J Vis Exp, (54), . (2011)
• Calderon T, Wu W, Rawson R, Sakala E, Sowers L, Boskovic D, Angeles DM.  Effect of Mode of Birth on Purine and Malondialdehyde in Umbilical Arterial Plasma in Normal Term Newborns.  J Perinatology, 2008, 28, 475-481   (10/2008)
• Plank M, Sowers L, Boskovic D, Angeles DM.  Biochemical markers of neonatal hypoxia. 2008.  Pediatric Health, 2:4, 485-501.   (02/2008)
• Angeles D, Ashwal S, Deming D, Yellon S, Hopper A, Peverini, R. Are elevated peripheral leukocytes markers of septic etiology in asphyxiated infants with neurological disability? J Perinatol 2008 Jan; 28(1): 85-6. (01/2008)
• Morkos A, Hopper A, Deming, D Yellon S, Wycliffe N, Ashwal S, Sowers L, Peverin R, Angeles D. Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates.  J Perinatol. 2007 Jun;27(6):365-70   (06/2007)
• Angeles DM, Ashwal S, Wycliffe N, Ebner C , Fayard E, Sowers L, Holshouser B.  2007.  Relationship Between Opioid Therapy, Tissue Damaging Procedures And Brain Metabolites As Measured By Proton MRS In Asphyxiated Term Neonates. Pediatr Res. 2007 May;61(5 Pt 1):614-21   (05/2007)
• Angeles DM, Pearce WJ.  Effect of dopamine on vascular reactivity in near-term lamb carotids: Role of the endothelium. 2006. Biol Res Nurs. 2006 Oct;8(2):97-103   (10/2006)
• Angeles DM, Wycliffe N, Michelson D, Holshouser B, Deming D, Pearce W, Sowers L, Ashwal S.  2005.  Use of opioids in asphyxiated term neonatesl  Effects on neuroimaging and clinical outcomes. Pediatric Research,  57(6), 873-878   (06/2006)
• Angeles DM, Chang M, Leong V, Pearce WJ.  Dexamethasone alters vascular reactivity by enhancing COX-related vasodilation in fetal ovine carotids. 2006. Biology of the Neonate, 90(1):1-8. Epub 2005 Dec 14   (01/2006)
• Angeles DM, Wycliffe N, Michelson D, Holshouser BA, Deming DD, Pearce WJ, Sowers LC, Ashwal S.. "Use of opioids in asphyxiated term neonates: effects on neuroimaging and clinical outcome.." Pediatric Research 57.6 (2005): 873-878. (07/2005)
• Angeles DM, Williams J, Purdy RE, Zhang L, Pearce WJ.. "Effects of maturation and acute hypoxia on receptor-IP(3) coupling in ovine common carotid arteries.." Am J Physiol Regul Integr Comp Physiol. 280.2 (2001): R410-R417. (01/2001)
• Angeles DM, Williams J, Zhang L, Pearce WJ. . "Acute hypoxia modulates 5-HT receptor density and agonist affinity in fetal and adult ovine carotid arteries.." Am J Physiol Heart Circ Physiol 279.2 (2000): H502-H510. (01/2000)
• Angeles DM.. "Pathophysiology and nursing management of persistent pulmonary hypertension of the newborn.." MCN Am J Matern Child Nurs. . (1992): 314-321. (01/1992)
• Angeles DM.. "An Orem-based NICU orientation checklist.." Neonatal Netw . (1991): 43-48. (01/1991)

Book Review - Scholarly Journals--Published

• Mousselli I, Faison GM, Angeles DM, Boskovic DS. Platelets in the newborn. 2019 Neonatal Medicine, Chapter 4. IntechOpen (05/2019)
• Calderon T, Boskovic D, Sowers L, Angeles DM.  Use of purines and xanthine oxidase as markers of neonatal hypoxia-ischemia. 2008.  Advances in Neurological Research, 209-277.  Research Signposts, Editor:  John H. Zhang   (01/2008)