Scholarly Journals--Published

  •       Zhang XB, Li K, Yau KH, Tsang KT, Fok TF, Li CK, Lee SM, Yuen PMM: Trehalose ameliorates the cryopreservation of cord blood in a preclinical system and increases the recovery of CFUs, long-term culture-initiating cells, and nonobese diabetic-SCID repopulating cells. Transfusion 43: 265-272, 2003 (PMID: 12559024).    Zhang XB, Beard BC, Beebe K, Storer B, Humphries RK, Kiem HP. Differential effects of HOXB4 on nonhuman primate short- and long-term repopulating cells.  PLoS Medicine 3: e173, 2006 (PMID: 16637742).  Zhang XB, Schwartz,JL, Humphries RK, Kiem HP: Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different species. Stem Cells, 25:2074-81, 2007 (PMID: 17510218 ).    Zhang XB, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, Humphries RK, Kiem HP: High incidence of leukemia after stem cell gene therapy in large animals with a HOXB4-expressing retroviral vector. J Clin Invest, 118(4):1502-1510, 2008.    Wang H, Li ZY, Liu Y, Persson J, Beyer I, Möller T, Koyuncu D, Drescher MR, Strauss R, Zhang XB, Wahl JK, Urban N, Drescher C, Hemminki A, Fender P, Lieber A: Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11, and 14. Nature Medicine, 2011 Jan;17(1):96-104. PMID: 21151137.    Meng X, Neises A, Su RJ, Payne KJ, Ritter L, Gridley DS, Wang J, Sheng M, Lau KH, Baylink DJ, Zhang XB: Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 alone. Molecular Therapy, 2012;20(2):408-16. doi: 10.1038/mt.2011.258. Epub 2011 Nov 22. (Corresponding author)    Meng X*, Su RJ*, Baylink DJ, Neises A, Kiroyan JB, Lee W, Payne KJ, Gridley DS, Wang J, Lau KHW, Li G, Zhang XB: Rapid and efficient reprogramming of human fetal and adult blood CD34+ cells into mesenchymal stem cells with a single factor. Cell Research. 2013, May;23(5):658-72. doi: 10.1038/cr.2013.40. (Impact factor: 14) (Corresponding author)    Su RJ, Baylink DJ, Neises A, Kiroyan JB, Meng X, Payne KJ, Tschudy-Seney B, Duan Y, Appleby N, Kearns-Jonker M, Gridley DS, Wang J, Lau KHW, Zhang XB: Efficient generation of integration-free iPS cells from human adult peripheral blood using BCL-XL together with Yamanaka factors. PLoS One. 2013, 8(5): e64496. doi:10.1371/journal.pone.0064496. (Corresponding author)    Zhang XB: Cellular reprogramming of human peripheral blood cells. Genomics Proteomics Bioinformatics. 2013 Oct;11(5):264-74. doi: 10.1016/j.gpb.2013.09.001. (Corresponding author)    Chen W, Baylink DJ, Brier-Jones J, Neises A, Kiroyan JB, Rundle CH, Lau KHW, Zhang XB: PDGFB-based stem cell therapy increases bone strength in the mouse. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3893-900. doi: 10.1073/pnas.1501759112. (Corresponding author)  Chen W, Baylink DJ, Lau KH, Zhang XB: Generation of mesenchymal stem cells by blood cell reprogramming. Curr Stem Cell Res Ther. 2016;11(2):114-21. (Corresponding author)  Su RJ, Neises A, Zhang XB: Generation of iPS cells from human peripheral blood mononuclear cells using episomal vectors. Methods Mol Biol. 2016;1357:57-69. (Corresponding author)  Wen W#, Zhang JP#, Xu J#, Su RJ, Neises A, Ji GZ, Yuan W, Cheng T*, Zhang XB*. Enhanced generation of integration-free iPSCs from human adult peripheral blood mononuclear cells with an optimal combination of episomal vectors. Stem Cell Reports. 2016 Jun 14;6(6):873-84. (Corresponding author) Zhang JP#, Li XL#, Neises A, Chen W, Hu LP, Ji GZ, Yu JY, Xu J, Yuan WP, Cheng T*, Zhang XB*. Different effects of sgRNA length on CRISPR-mediated gene knockout efficiency. Sci Rep. 2016 Jun 24;6:28566. PMCID: PMC4919781(Corresponding author) Zhang JP#, Li XL#, Li GH, Chen W, Arakaki C, Botimer GD, Baylink  D, Zhang L, Wen W, Fu YW, Xu J, Chun N, Yuan W, Cheng T*, Zhang XB*. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated dsDNA cleavage. Genome Biology. 2017 Feb 20;18(1):35. doi: 10.1186/s13059-017-1164-8. (Corresponding author) Wen W, Cheng X, Fu Y, Meng F, Zhang JP, Zhang L, Li XL, Yang Z, Xu J, Zhang F, Botimer GD, Yuan W, Sun C, Cheng T#, Zhang XB#. High-Level precise knockin of iPSCs by simultaneous reprogramming and genome editing of human peripheral blood mononuclear cells. Stem Cell Reports. 2018 Jun 5;10(6):1821-1834. (Corresponding author) Li XL*, Li GH*, Fu J*, Fu YW, Zhang L, Chen WQ, Arakaki C, Zhang JP, Wen W, Botimer GD, Baylink D, Aranda L, Choi H, Bechar R, Talbot P, Sun CK#, Cheng T#, Zhang XB#. Highly-efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by BCL-XL. Nucleic Acid Research, 2018 Sep 20. doi: 10.1093/nar/gky804. (Corresponding author)   Pizzute T, He F, Zhang XB#, Pei M#. Impact of Wnt signals on human intervertebral disc cell regeneration. J Orthop Res. 2018 Dec;36(12):3196-3207. (Co-Corresponding author) Zhou S, Fu Y, Zhang XB#, Pei M#. Liver Kinase B1 Fine-Tunes Lineage Commitment of Human Fetal Synovium-Derived Stem Cells. J Orthop Res. 2019 Aug 20. doi: 10.1002/jor.24449. (Co-Corresponding author)     Other co-authored papers published in 2018 and 2019   Lyu C, Shen J, Wang R, Gu H, Zhang J, Xue F, Liu X, Liu W, Fu R, Zhang L, Li H, Zhang X, Cheng T, Yang R, Zhang L. Targeted genome engineering in human induced pluripotent stem cells from patients with hemophilia B using the CRISPR-Cas9 system. Stem Cell Res Ther. 2018 Apr 6;9(1):92. doi: 10.1186/s13287-018-0839-8. Guo H, Chu Y, Wang L, Chen X, Chen Y, Cheng H, Zhang L, Zhou Y, Yang FC, Cheng T, Xu M, Zhang X, Zhou J, Yuan W. PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia. Int J Cancer. 2017 Jul 15;141(2):324-335. doi: 10.1002/ijc.30739. Epub 2017 May 8. Gu H, Huang X, Xu J, Song L, Liu S, Zhang XB, Yuan W, Li Y. Optimizing the method for generation of integration-free induced pluripotent stem cells from human peripheral blood. Stem Cell Res Ther. 2018 Jun 15;9(1):163. doi: 10.1186/s13287-018-0908-z. Zhang L, Liu C, Wang H, Wu D, Su P, Wang M, Guo J, Zhao S, Dong S, Zhou W, Arakaki C, Zhang X, Zhou J. Thrombopoietin knock-in augments platelet generation from human embryonic stem cells. Stem Cell Res Ther. 2018 Jul 17;9(1):194. doi: 10.1186/s13287-018-0926-x Leung KT, Zhang C, Chan KYY, Li K, Cheung JTK, Ng MHL, Zhang XB, Sit T, Lee WYW, Kang W, To KF, Yu JWS, Man TKF, Wang H, Tsang KS, Cheng FWT, Lam GKS, Chow TW, Leung AWK, Leung TF, Yuen PMP, Ng PC, Li CK. CD9 blockade suppresses disease progression of high-risk pediatric B-cell precursor acute lymphoblastic leukemia and enhances chemosensitivity. Leukemia. 2019 Oct 17. doi: 10.1038/s41375-019-0593-7. (11/2019)