Publications

Books and Chapters

• Rivers EP, Otero RM, Nguyen HB.  Approach to the patient in shock. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 6th Edition, 2004:219-25. Rivers EP, Nguyen HB, Osborn T, Gaieski D, Goyal M, Gunnerson K, Trzeciak S, Sherwin R, Holthaus C, Otero R.  Early goal-directed therapy in severe sepsis and septic shock.  In: Kuhlen R, Moreno R, Ranieri M, Rhodes A.  ESICM, 25 Years of Progress and Innovation, 1st Edition, 2007:189-97. Greenwald PW, Weingart Sc, Nguyen HB. Severe sepsis and septic shock. In: Rowe B. Evidence-based Emergency Medicine, 1st Edition, 2008. Otero RM, Nguyen HB, Rivers EP. Approach to the patient in shock. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 7th Edition. 2010. Nguyen HB, Huang DT, Pinsky MR.  Hemodynamic monitoring. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 7th Edition. 2010. Walters EL, Nguyen HB. Hemodynamic monitoring and perfusion monitoring. In: Flaxman A. Critical Care Emergency Medicine, 1st Edition, 2011. Nguyen HB. Monitoring Technology: Invasive and Non-invasive. In: Yealy D, Callaway C. Emergency Department Critical Care, 1st Edition, 2011. Nguyen HB, Huang DT, Pinsky MR. Hemodynamic Monitoring. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 8th Edition. 2015. Walters EL, Dinh VA, Nguyen HB. Hemodynamic monitoring and perfusion monitoring. In: Farcy DA. Critical Care Emergency Medicine, 2nd Edition, 2015. (Present)

Scholarly Journals--Published

• Nguyen HB, Evans WJ. Olfactory evoked potentials in normal human subjects.  J Undergraduate Res Bio Sci 1993;23:737-48. [Original Research] Estacion M, Nguyen HB, Gargus JJ.  Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L-cells. Am J of Physio 1996; 270:C1145-52. [Original Research] Nguyen HB, Estacion M, Gargus JJ.  Mutations causing achondroplasia and thanatophoric dysplasia alter bFGF induced calcium signals in human diploid fibroblasts. Hum Mol Gen 1997;6:681-9. [Original Research] Nguyen HB, Rivers EP, Havstad S, Knoblich B, Hays G, Ressler J, Tomlanovich MC.  Critical care delivery in the emergency department:  A physiologic assessment and outcome evaluation. Acad Emerg Med 2000;7:1354-61. [Original Research] Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M.  Early goal-directed therapy in the treatment of severe sepsis and septic shock.  N Engl J Med 2001;345:1368-77. [Original Research] Rivers EP, Nguyen HB. Goal-directed therapy for severe sepsis. N Engl J Med 2002; 346:1025-6. [Correspondence] Rivers EP, Nguyen HB, Huang DT, Donnino M. Critical care and emergency medicine.  Curr Opin Crit Care 2002;8:600-6. [Review] Rivers EP, Nguyen HB, Amponsah D. Sepsis:  A landscape from the emergency department to the intensive care unit. Crit Care Med 2003; 31:968-9. [Editorial] Donnino MW, Karriem-Norwood V, Rivers EP, Gupta A, Nguyen HB, Jacobsen G, McCord J, Tomlanovich MC.  Prevalence of elevated troponin I in end stage renal disease patients receiving hemodialysis. Acad Emerg Med 2004;11: 979-981. [Original Research] Rivers EP, Nguyen HB, Huang DT, Donnino M. Cardiovascular management of septic shock. Crit Care Med 2004; 32:314-5. [Correspondence] Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin AM, Ressler J, Tomlanovich MC. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004;32:1637-42. [Original Research, Feature Article] Cuschieri J, Rivers EP, Donnino MW, Katilius M, Jacobsen G, Nguyen HB, Pamukov N, Horst HM.  Central venous-arterial carbon dioxide difference as an indicator of cardiac index. Int Care Med 2005;31:818-22. [Original Research] Hargrove J, Nguyen HB.  Outcome predictions for the critically ill patients in the emergency department.  Crit Care 2005;9:376-383. [Invited Review] Nguyen HB, Rivers EP. The clinical practice of early goal-directed therapy in severe sepsis and septic shock.  Adv Sepsis 2005;4:126-33. [Invited Review, Leading Article] Osborn TM, Nguyen HB, Rivers EP.  Emergency medicine and the surviving sepsis campaign: An international approach to managing severe sepsis and septic shock.  Ann Emerg Med 2005;46:228-31. [Invited Review] Nguyen HB, Corbett SW, Menes K, Cho T, McDaugharthy J, Klein W, Wittlake WA. Early goal-directed therapy, corticosteroid and recombinant human activated protein C for the treatment of severe sepsis and septic shock in the emergency department.  Acad Emerg Med 2006;13:109-13. [Original Research] Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trezciak S, Huang D, Osborn T, Stevens D, Talan DA.  Severe sepsis and septic shock: Review of the literature and emergency department management guidelines.  Ann Emerg Med 2006;48:28-54. [Practice Guidelines] Nguyen HB, Corbett SW. The implementation of new therapies for severe sepsis. Acad Emerg Med 2006; 13:999-1000. [Invited Editorial] Nguyen HB, Losey T, Rasmussen J, Oliver R, Guptill M, Wittlake WA, Corbett SW. Inter-rater agreement of a transcutaneous Doppler ultrasound cardiac output monitoring device: Implications for non-invasive hemodynamic monitoring in emergency department patients. Am J Emerg Med 2006;24:828:35. [Original Research] Otero R, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson K, Trzeciak S, Sherwin R, Holthaus CV, Osborn T, Jacobson G, Rivers EP. Early goal directed therapy in severe sepsis and septic shock: Revisiting the concepts, controversies and contemporary findings. Chest 2006;130:1579-95. [Invited Review] Mou J, Lyon K, Nguyen HB.  The nuts and bolts of sepsis program implementation in the emergency department.  Emerg Med Crit Care Rev 2006;42-44. [Invited Review] Nguyen HB, Smith D. Sepsis in the 21st century: Recent definitions and therapeutic advances.  Am J Emerg Med 2006;25:564-71. [Review] Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes S, Edwards J, Cho T, Wittlake WA. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality.  Crit Care Med 2007;35:1105-12. [Original Research] Nguyen HB, Lynch EL, Mou JA, Lyon K, Wittlake WA, Corbett SW.  The utility of a quality improvement bundle in bridging the gap between research and standard care in the management of severe sepsis and septic shock in the emergency department. Acad Emerg Med 2007;14:1079-86. [Special Contribution] Gregorius DD, Dawood R, Ruh K, Nguyen HB. Severe high altitude pulmonary edema: A patient managed successfully with non-invasive positive pressure ventilation in the emergency department. Emerg Med J 2008;25:243-4. [Case Report] Nguyen HB, Banta J, Cho T, Van Ginkel C, Burroughs K, Wittlake WA, Corbett SW. Mortality predictions using current physiologic scoring systems in patients meeting criteria for early goal-directed therapy and the severe sepsis resuscitation bundle.  Shock 2008;30:23-8. [Original Research] Nguyen HB. Dear SIRS, can MEDS help you predict patient outcome now, really? Crit Care Med 2008; 36:625-6. [Invited Editorial] Stewart GM, Nguyen HB, Kim TY, Jauregui J, Hayes S, Wittlake WA, Corbett SW.  Inter-rater reliability for non-invasive measurement of cardiac function in children. Ped Emerg Care 2008;24:433-7. [Original Research] Vemulakonda S, Nguyen HB. Severe sepsis and septic shock: Recent updates in definitions, treatments, and quality improvement.  International Hospital and Equipment 2008;34:18-20. [Invited Featured Review Article] Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP. A prospective, multi-center derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis.  Critical Care Med 2009;37:96-104. [Original Research] Holthaus CV, Cannon C, Elkin R, Nguyen HB. Can my severe sepsis and septic shock patients wait any longer? Ann Emerg Med 2009; 54:135-6. [Editorial] Nguyen HB, Daniel-Underwood L, Van Ginkel C, Wong M, Lee D, San Lucas A, Palaganas J, Banta D, Denmark TK, Clem K.  An educational course including medical simulation for early goal-directed therapy and the severe sepsis resuscitation bundle: An evaluation for medical student training. Resuscitation 2009;80:674-79. [Original Research] Carpenter CR, Keim SM, Upadhye S, Nguyen HB. Risk stratification of the potentially septic patient in the emergency department: The Mortality in the Emergency Department Sepsis (MEDS) score. J Emerg Med 2009;37:319-27. [Invited Systematic Review] Nguyen HB, Oh J, Otero R, Burroughs K, Wittlake WA, Corbett SW. Standardization of severe sepsis management: A survey of methodologies in academic and community settings.  J Emerg Med 2010;38:122-30. [Original Research] Nguyen HB, Loomba M, Yang JJ, Jacobsen G, Shah K, Otero RM, Suarez A, Parekh H, Rivers EP. Early lactate clearance is associated with decreased biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. J Inflamm 2010;7:6-17. [Original Research] Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, Gaieski DF, Goyal M, Cairns CB, Kupfer K, Lee SW, Rivers EP. The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) in the prediction of acute kidney injury in emergency department patients with suspected sepsis.  Ann Emerg Med 2010;56:52-9. [Original Research] Nguyen HB, Banta DP, Stewart G, Kim T, Bansal R, Anholm J, Wittlake WA, Corbett SW. Cardiac index measurements by transcutaneous Doppler ultrasound and transthoracic echocardiography in adult and pediatric emergency patients. Journal of Clinical Monitoring and Computing 2010;24:237-47. [Original Research] Walters EL, Morawski K, Dorotta I, Ramsingh D, Lumen K, Bland D, Clem K, Nguyen HB.  Implementation of a post-cardiac arrest bundle including therapeutic hypothermia and early goal-directed therapy in patients with return of spontaneous circulation after out-of-hospital cardiac arrest: A feasibility study. Shock 2011;35:360-6.  [Original Research] Perman SM, Chang AM, Hollander JE, Gaieski Df, Trzeciak S, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Goyal M, Cairns CB, Ngo L, Rivers EP, Shapiro NI. Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Acad Emerg Med 2011;18:219-22. [Original Research] Nguyen HB, Kuan WS, Batech M, Shrikhande P, Mahadevan M, Li CH, Ray S, Dengel A, for the ATLAS Investigators.  Outcome effectiveness of the severe sepsis bundle with addition of lactate clearance as a bundle element: A multi-national evaluation. Crit Care 2011;15:R229. [Original Research] Kinney-Ham L, Nguyen HB, Steele R, Walters EL. Acute aortic dissection in a third trimester pregnancy with no risk factors. West J Emerg Med 2011:12:571-4. [Case Report] Nguyen HB. Lactate in the critically ill patients: An outcome marker with the times. Crit Care 2011;15:1016. [Invited Commentary] Nguyen HB, Van Ginkel C, Batech M, Chenoweth J, Banta J, Kim S, Corbett SW. Comparison of PIRO, APACHE II, and MEDS in patients meeting criteria for early goal-directed therapy and the severe sepsis resuscitation bundle. J Critical Care 2012; 27:362-9. [Original Research] Li CH, Kuan WS, Mahadevan M, Daniel-Underwood L, Chiu TF, Nguyen HB. A multinational randomized study comparing didactic lectures with case scenario in a severe sepsis medical simulation course. Emerg Med J 2012; 29:559-64. [Original Research] Dinh VA, Ko HS, Rao R, Bansal RC, Smith DD, Kim TE, Nguyen HB. Measuring cardiac index with a focused cardiac ultrasound examination in the emergency department. Am J Emerg Med 2012;30:1845-51. [Original Research] Na S, Kuan WS, Mahadevan M, Li CH, Shrikhande P, Ray S, Batech M, Nguyen HB, for the ATLAS Investigators.  Implementation of early goal-directed therapy and the Surviving Sepsis Campaign resuscitation bundle in Asia. Int J Qual Health Care 2012;24:452-462. [Original Research] Banta JE, Joshi KP, Beeson L, Nguyen HB. Patient and hospital characteristics associated with inpatient severe sepsis mortality in California, 2005-2010. Crit Care Med 2012;40:2960-6. [Original Research] Ng D, Klein W, Tran R, Riddle-Branske D, Luna PJ, Nguyen HB. Combination therapy with high frequency oscillatory ventilation, neuromuscular blockade, inhaled nitric oxide, and prone position in acute respiratory distress syndrome with refractory hypoxemia. Anaesthesia and Intensive Care 2012;40:898-9. [Case Report and Review] Parekh HJ, Nguyen HB, Hall SL, Rehage M, Anholm J, Specth L, Linkhart TA. Direct pro-inflammatory effect of C-reactive protein on human pulmonary artery endothelial cells. Eur J Inflam 2012;10:357-64. [Original Research] Rivers EP, Jaehne AK, Nguyen HB, Papamatheakis DG, Singer D, Yang JJ, Brown S, Klausner H. Early biomarker activity in severe sepsis and septic shock and a contemporary review of immunotherapy trials: Not a time to give up, but to give it earlier. Shock 2013;39:127-37. [Original Research and Review] Nguyen HB. Central venous oxygen saturation: Not easily replaced. Crit Care Med 2013;41:1570-71. [Invited Editorial] Nguyen HB, Dinh VA. Solely targeting “Alactatemia” in septic shock resuscitation? Let’s be cautious, it’s not so simple. Chest 2013;143:1521-23. [Invited Editorial] Nguyen HB, Eshete B, Lau KHW, Sai A, Villarin M, Baylink D.  Serum 1,25-dihydroxyvitamin D: An outcome prognosticator in human sepsis. PLOS ONE 2013;8:e64348. [Original Research] Farshidpanah S, Klein WF, Matus MJ, Sai AJ, Nguyen HB. Validation of the vascular pedicle width as a diagnostic aid in critically ill patients with pulmonary edema by novice non-radiology physicians in-training. Anaesth Int Care 2014;42:321-29. [Original Resesarch] Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, DeMuth GE, Fitzgerald R, Gong MN, Graham DD, Gunnerson K, Heung M, Jortani S, Kleerup E, Koyner JL, Krell K, LeTourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM, Self WH, Sellman R, Shi J, Straseski J, Szalados JE, Wilber ST, Walker MG, Wilson J, Wunderink R, Zimmerman J, Kellum JA. Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am J Resp Crit Care Med 2014;189:832-39. [Original Research] Dinh VA, Farshidpanah S, Lu S, Stokes P, Chrissian A, Shah H, Giri P, Hecht D, Nguyen HB. Real-time ultrasound-guided percutaneous dilatational tracheostomy using a long-axis approach compared to landmark technique. J Ultra Med 2014;33:1407-15. [Original Research] Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Rivers EP, Shapiro NI. Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock 2014;42:99-107. [Original Research] Ani C, Farshidpanah S, Bellinghausen Stewart A, Nguyen HB. Variations in organism specific severe sepsis mortality in the United States: 1999-2008. Crit Care Med 2015;43:65-77. [Original Research] Brown TN, Ghelani-Allen A, Yeung D, Nguyen HB. Comparative effectiveness of physician diagnosis and guideline definitions in identifying sepsis patients in the emergency department. J Crit Care 2015;30:71-7. [Original Research] Tang Y, Choi J, Kim D, Tudtud-Hans L, Li J, Michel A, Baek H, Hurlow A, Wang C, Nguyen HB. Clinical predictors of adverse outcomes in severe sepsis patients with lactate 2 to 4 mM admitted from the emergency department. QJM 2015;108:279-87. [Original Research] Giri PC, Bellinghausen Stewart A, Dinh VA, Chrissian AA, Nguyen HB. Developing a percutaneous dilatational tracheostomy service by medical intensivists: Experience at one academic institution. J Crit Care 2015;30:321-6. [Original Research] Dinh VA, Giri PC, Rathinavel I, Nguyen E, Hecht D, Dorotta I, Nguyen HB, Chrissian AA. Impact of a 2-day critical care ultrasound course during fellowship training: A pilot study. Crit Care Res and Prac 2015; 675041. [Original Research] Honore PM, Nguyen HB, Gong M, Chawla LS, Bagshaw SM, Artigas A, Shi J, Joannes-Boyau O, Vincent JL, Kellum JA. Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-like Growth Factor-binding Protein 7 ([TIMP-2]*[IGFBP-7]) for risk stratification of acute kidney injury in patients with sepsis. Crit Care Med 2016; 44:1851-60. [Original Research] Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gray JG, Pflaum J, Domecq JP, Hurst G, Belsky J, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer D, Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: Insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care 2016; 20:160. [Review] Nguyen HB, Lu S, Possagnoli I, Stokes P. Comparative effectiveness of second vasoactive agents in septic shock refractory to norepinephrine. J Int Care Med 2017; 32:451-59 [Original Research] Andaluz-Ojeda D, Nguyen HB, Meunier-Beillard N, Cicuendez R, Quenot JP, Calvo D, Dargent A, Zarca E, Andres C, Nogales L, Eiros JM, Tamayo E, Gandia F, Bermejo-Martin J, Charles PE. Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity. Ann Int Care 2017; 7:15. [Original Research] Khanna A, English SW, Wang XS, et al. (Nguyen HB - Collaborating Site PI). Angiotensin II for the treatment of vasodilatory shock. N Engl J Med 2017; 377:419-430. [Original Research] Cao V, Tan L, Horn F, Bland D, Giri P, Maken K, Cho N, Scott L, Dinh V, Hidalgo D, Nguyen HB. Patient-centered structured interdisciplinary bedside rounds in the medical intensive care unit. Crit Care Med 2018; 46:85-92. [Original Research] Nguyen HB, Thomson CC, Kaminski N, Schnapp LM, Madison JM, Glenny RW, Dixon AE. Leadership primer for current and aspiring pulmonary, critical care, and sleep medicine academic division chiefs. Ann Am Thorac Soc 2018; 15:655-66. [Focused Review] Tumlin JA, Murugan R, Deane AM, et al. (Nguyen HB - Collaborating Site PI). Outcomes in patients with vasodilatory shock and renal replacement therapy treated with intravenous Angiotensin II. Crit Care Med 2018; 46:949-957. [Original Research] Cohen A, Tan L, Fargo R, Anholm J, Gasho C, Yaqub K, Chopra S, Hansen J, Huang C, Moretta D, Washburn D, Nguyen HB. A multi-center evaluation of a disposable catheter to aid in correct positioning of the endotracheal tube after intubation in critically ill patients. J Crit Care 2018; 48:222-227. [Original Research] Gluck E, Nguyen HB, Yalamanchili K, McCusker M, Madala J, Corvino FA, Zhu X, Balk R. Real-world use of procalcitonin and other biomarkers among sepsis hospitalizations in the United States: A retrospective, observational study. PLoS One 2018;13(10):e0205924 [Original Research] Dellinger RP, Bagshaw SM, Antonelli M, et al. (Nguyen HB - Collaborating Site PI). Effect of targeted Polymyxin B hemoperfusion on 28-day mortality in patients with septic shock and elevated endotoxin level: The EUPHRATES randomized clinical trial. JAMA 2018;320:1455-1463. [Original Research] Mewes JC, Pulia MS, Mansour MK, Broyles MR, Nguyen HB, Steuten LMG. The cost impact of PCT-guided antibiotic stewardship versus usual care for hospitalized patients with suspected sepsis or lower respiratory tract infections in the US: A health economic model analysis. PLoS One 2019;14(4):e0214222. [Original Research] Huang C, Daniels R, Lembo A, Hartog C, O’Brien J, Heymann T, Reinhart K, Nguyen HB. Life after sepsis: An international survey of survivors to understand the post-sepsis syndrome. Int J Qual Health Care 2019 Apr 1;31:191-198. [Original Research; selected as Most Cited in 2021 article] Litwak JJ, Cho N, Nguyen HB, Moussavi K, Bushell T. Vitamin C, hydrocortisone, and thiamine for the treatment of severe sepsis and septic shock: A retrospective analysis of real-world application. J Clin Med 2019 Apr 9;8(4).pii:E478. [Original Research] Wojcik B, Superata J, Nguyen HB, Szygula Z. Exploration of different rehabilitation routes for sepsis survivors with monitoring of health status and quality of life: RehaSep trial protocol. Adv Ther 2019;36:2968-78. [Original Research] Chopra S, Thompson J, Shahangian S, Thapamagar S, Moretta D, Gasho C, Cohen A, Nguyen HB. Precision and consistency of the passive leg raising maneuver for determining fluid responsiveness with bioreactance non-invasive cardiac output monitoring in critically ill patients and healthy volunteers. PLoS One 2019; 14(9):e0222956. Nguyen HB, Thomson C, Jarjour NN, Dixon AE, Liesching TN, Schnapp LM, Madison JM, Murin S, Glenny R, Kaminski N. Leading change and negotiation strategies for division leaders in clinical medicine. CHEST 2019; 156:1246-53. [Contemporary Review] Li CH, Tang X, Wasnik S, Wang X, Zhang J, Xu Y, Lau KW, Nguyen HB, Baylink DJ. Mechanistic study of the cause of decreased blood 1,25-dihydroxyvitamin D in sepsis. BMC Infectious Disease 2019; 19:1020. [Original Research] Russell A, Rivers EP, Giri PC, Jaehne AK, Nguyen HB. A physiologic approach to hemodynamic monitoring and optimizing oxygen delivery in shock resuscitation. J. Clin Med 2020; 9, 2052. [Review; selected as Top 10 Most Meritorious article] Rappo U, Nguyen HB, Puttagunta S, Ojaimi C, Akinapelli K, Dunne M. Necrotizing fasciitis within the first 72 hours after presentation with skin and skin structure infection. WestJEM 2020; 21:943-48. [Original Research] Bellomo R, Forni LG, Busse LW, et al. for the ATHOS-3 Investigators. (Nguyen HB – Collaborating Site PI). Renin and survival in patients given Angiotensin II for catecholamine-resistant vasodilatory shock. Am J Resp Crit Cre Med 2020; 202:1253-61. [Original Research] Gupta S, Hayek S, Wang W, et al. for the STOP-COVID Investigators. (Nguyen HB – Collaborating Site PI). Factors associated with death in critically ill patients with coronavirus disease 2019 in the U.S. JAMA Int Med 2020; 180:1-12. [Original Research] Mohan R, Ho P, Dalton L, Chan F, Nguyen HB. Deriving a patient de-identified clinical research database from an electronic health record system: A single center experience in determining the prognostic value of lactate, C-reactive protein, and procalcitonin in hospitalized patients. J Transl Sci 2020; 7:1-6. [Original Research] Molnar MZ, Bhalla A, Azhar A, et al. for the STOP-COVID Investigators. (Nguyen HB – Collaborating Site PI). Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States. Am J Tranplant 2020; 11: 3061-71. Hayek SS, Brenner SK, Azam TU, et al. for the STOP-COVID Investigators. (Nguyen HB – Collaborating Site PI). In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. BMJ 2020; 371:m3513. [Original Research] Gupta S, Wang W, Hayek SS, et al. for the STOP-COVID Investigators. (Nguyen HB – Collaborating Site PI). Association between Early Treatment with tocilizumab and mortality among critically ill patients with COVID-19. JAMA Int Med 2021; 181:41-51. [Original Research] Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE; STOP-COVID Investigators. AKI treated with renal replacement therapy in critically ill patients with COVID-19. J Amer Soc Neph 2021; 32:161-76. [Original Research] Flythe JE, Assimon MM, Tugman MJ, et al. for the STOP-COVID Investigators. (Nguyen HB – Collaborating Site PI). Characteristics and outcomes of individuals with pre-existing kidney disease and COVID-19 admitted to intensive care units in the United States. Am J Kidney Dis 2021;77:190-203. [Original Research] Kellum JA, Artigas A, Gunnerson K, Honore PM, Kampf P, Kwan T, McPherson P, Nguyen HB, Rimmele T, Shapiro NI, Shi J, Vincent JL, Chawla LS, for the Sapphire Investigators. Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients with Infection. Crit Care Med 2021;49:e360-68. [Original Research] Shaefi S, Brenner SK, Gupta S, et al. for the STOP-COVID Investigators. (Nguyen HB – Collaborating Site PI). Extracorporeal Membrane Oxygenation in Patients with Severe Respiratory Failure from COVID-19. Int Care Med 2021;47:208-21. [Original Research] Al-Samkari H, Gupta S, Leaf RK, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Thrombosis, bleeding, and the observational effect of early therapeutic anticoagulation on survival in critically ill patients with COVID-19. Ann Int Med 2021:174:622-632. [Original Research] Mathews KS, Soh H, Shaefi S, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Prone positioning and survival in mechanically ventilated patients with COVID-19-related respiratory failure. Crit Care Med 2021;49:1026-1037. [Original Research] Short S, Gupta S, Brenner S, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). D-dimer and death in critically ill patients with Coronavirus Disease 2019. Crit Care Med 2021;49:e500-11. [Original Research] Churpek MM, Gupta S, Spicer AB, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Hospital-level variation in death for critically ill patients with COVID-19. Am J Respir Crit Care Med 2021;204:403-11. [Original Research] Vasquez CR, Gupta S, Miano TA, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Identification of distinct clinical subphenotypes in critically ill patients with COVID-19. CHEST 2021;160:929-943. [Original Research] Friedman AN, Guirguis J, Kapoor R, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients COVID-19 in the US. Obesity 2021;29:1719-30. [Original Research] Jezmir JL, Bharadwaj M, Chaitoff A, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States. Cell Rep Med 2021;2:100376. [Original Research] Churpek MM, Gupta S, Spicer AB, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Machine learning prediction of death in critically ill patients with Coronavirus Disease 2019. Crit Care Explor 2021;3:e0515. [Original Research] Moosa A, Win S, Abdi pour A, Kim CK, Nguyen HB. Mortality benefit from the passive leg raise maneuver in guiding resuscitation of septic shock patients: A systematic review and meta-analysis of randomized trials.  J Int Care Med 2022; 37:611-17. [Original Research] Townsend SR, Phillips GS, Duseja R, Tefera L, Cruikshank D, Dickerson R, Nguyen HB, Levy MM, Dellinger RP, Browner WS, Conway WA, Rivers EP.  Effects of compliance on the early management bundle (SEP-1) on mortality changes among medical beneficiaries with sepsis: A propensity score matched cohort study. CHEST 2022; 161:392-406. [Original Research] Hsu CM, Gupta S, Tighiouart H, et al. for the STOP-COVID Investigators (Nguyen HB – Collaborating Site PI). Kidney recovery and death in critically ill patients with COVID-19-associated acute kidney injury treated with dialysis. Am J Kidney Dis 2022;79:404-16. [Original Research] Quan M, Cho N, Bushell, T, Mak J, Nguyen N, Litwak J, Rockwood N, Nguyen HB. Effectiveness of Angiotensin II for catecholamine refractory septic or distributive shock on mortality: A propensity score weighted analysis of real-world experience in the medical intensive care unit. Crit Care Explor 2022; 4:e0623. [Original Research] (Present)